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NuVasive Acquires First Stem Cell Bone Graft Substitute

New technologies will drive US bone graft substitute market to reach almost

$1.9 billion by 2012, according to Millennium Research Group

WALTHAM, Mass., May 14 /PRNewswire/ -- With the acquisition of Osiris Therapeutics' Osteocel business, NuVasive has obtained the first off-the-shelf bone graft substitute (BGS) product to incorporate viable stem cells. Mounting surgeon excitement about this new BGS and other innovative products will drive the BGS market to $1.9 billion in 2012, according to Millennium Research Group's US Markets for Orthopedic Biomaterials 2008 report.

"The popularity of advanced BGS technologies has increased competition within the field. Medtronic Spinal and Biologics' INFUSE BGS, based on a recombinant human bone morphogenetic protein, has forced NuVasive and other BGS competitors to dramatically innovate," says Kevin Flewwelling, Orthopedics Research Manager at Millennium Research Group. "In 2007, INFUSE sales exceeded $700 million in the US and NuVasive saw an opportunity to compete against this very successful product."

In order to compete against these advanced BGS, other manufacturers of traditional BGS products -- such as demineralized bone matrices and synthetics -- are developing next-generation products that offer improved ease-of-use and superior bone healing and regrowth. Companies claim that these new features eliminate the need for autograft bone harvested from the patient's iliac crest, reducing postoperative pain and morbidity at the donor site. With these greater advantages, surgeons are shifting towards these newer devices. A survey of surgeons conducted by Millennium Research Group found that 30.3% expected to perform fewer procedures using only autograft bone by 2012.

In addition to the BGS market, the US Markets for Orthopedic Biomaterials 2008 report covers the hyaluronic acid viscosupplementation, machined bone interbody device, knee cartilage repair, and cell concentration system markets. The report also provides coverage of all key industry competitors, including AlloSource, Biomet, Blackstone Medical/Orthofix, DePuy, Exactech, Ferring Pharmaceuticals, Genzyme Biosurgery, Integra LifeSciences/IsoTis, LifeNet Health, Medtronic Spinal and Biologics, Musculoskeletal Transplant Foundation, Orthovita, Osiris Therapeutics, Osteotech, RTI Biologics, sanofi-aventis, Smith & Nephew, Stryker, Synthes, and Wright Medical Technology. Other reports in this series cover Europe (France, Germany, Italy, Spain, and the UK) and Japan.

About Bone Graft Substitutes

BGS are classified under the broader term of bone grafts. Bone grafts are used to promote bone healing and regrowth and fill bone voids in spinal fusion, trauma surgery, joint revision and reconstruction, and craniomaxillofacial surgery. These products can be classified into six categories: autograft, nonproprietary allograft, demineralized bone matrix, synthetics, growth factors -- such as bone morphogenetic proteins -- and stem cell products. Autograft is the only bone graft material that is taken from a patient's own body. Other bone graft materials are commonly referred to as BGS.

About Millennium Research Group

Millennium Research Group (, a Decision Resources, Inc. company (, is the global authority on medical technology market intelligence and a leading provider of strategic information to the health care sector. Focused solely on the medical device, pharmaceutical, and biotechnology industries, the company provides its clients with the benefits of its specialized industry expertise through published reports and customized consulting services.

All company, brand, or product names contained in this document may be trademarks or registered trademarks of their respective holders.

For more information, contact:

Amy Krohn

Millennium Research Group

416-364-7776 x101

SOURCE Millennium Research Group
Copyright©2008 PR Newswire.
All rights reserved

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