NovoCure presents results from breast cancer p...(r the kidney capsule of rabbits. This i...),Health

NovoCure built upon the animal and laboratory work with a single-arm human pilot trial to determine the safety and efficacy of the Novo-TTF with neo-adjuvant chemotherapy (doxorubicin or epirubicin together with docetaxel) in locally advanced breast cancer patients. This study is under way. Neo-adjuvant refers to chemotherapy delivered in advance of surgery in an effort to shrink the tumor so as to improve operative outcomes. The early results from the first four patients with combined therapy to date indicate that tumor volume shrank significantly by 86%, 89% and 96% and an additional patient has experienced a complete response.

The Novo-TTF is currently being studied in patients with brain cancer and breast cancer. Treatment related toxicity is a major limitation of all current cancer treatments and often prevents the delivery of effective doses. No clinically significant side effects due to the Novo-TTF have been seen throughout these trials to date. The only device-related side effect observed was a mild to moderate contact dermatitis beneath the electrodes, which responded well to the application of topical cream and periodic electrode relocation.

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