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Novel vaccine concept developed by scientists at the Wistar Institute
Date:1/31/2008

man molecules, making it likely that the method will also work in people, Lasaro says.

Ertl says the ability of the glycoprotein D carrier protein to enhance the immune response could be particularly important to the development of a long-sought vaccine for AIDS. The problem with HIV vaccines is that they might look good in mice and primates, but comparable doses in humans are too toxic, she says. If you lower the dose to avoid toxic side effects, you dont get the immune response you need. She believes that using glycoprotein D may solve that problem.

Ertl and her colleagues are planning future studies to further elucidate the mechanism behind the carrier proteins effectiveness. If studies in research animals continue to be positive, they hope to conduct human clinical studies with HIV and HPV vaccines currently under development at The Wistar Institute Vaccine Center.

The Wistar Institute has filed for patent protection on the glycoprotein D carrier protein technology.


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Contact: Abbey Porter
aporter@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

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