Navigation Links
Novel toxin receptor discovered for ulcer-causing stomach pathogen
Date:5/23/2008

rily of lipids and proteins and are designed to keep things out. Some molecules can penetrate them, but most can do so only after binding to a specific membrane component, called a receptor. Receptors sometimes act as keys that open channels through a membrane, or they function as signaling molecules, communicating to other components in the cell.

Blankes team knew that VacA was latching on to something on the cell surface that was helping it across the membrane.

Other studies had shown that VacA bound to lipids within artificially created membranes, so graduate students Vijay Gupta and Hetal Patel screened a number of lipids for VacA binding and soon found one to which the toxin readily attached. This lipid, called sphingomyelin, is an important and abundant component of the membrane of some animal cells. (Foods such as milk, meat, fish and eggs are dietary sources of sphingomyelin.)

To be considered a receptor, a molecule must meet two criteria, Blanke said. It must bind the agent of interest (in this case VacA) to the cell surface, and it must confer sensitivity to that agent. In other words, a receptor to VacA must be essential to the process by which VacA gets into a cell. If you removed the receptor, or blocked it, the toxin would lose its ability to bind or function. Prior to this study, no molecules on the membrane of human cells had been found that satisfied both criteria as a receptor.

Upon entering cells, VacA spurs the formation of giant vacuoles. These oversized membrane-bound compartments are easy to spot under a microscope and provide a useful indicator of VacA activity in the cell.

To test whether sphingomyelin was a receptor for VacA, Gupta treated cultured human cells with an enzyme that depleted the membranes of sphingomyelin. In the sphingomyelin-depleted cells, the toxin lost its ability to cross into the cells and the giant vacuoles disappeared. When he restored sphingomyelin to the same cell membra
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Novel enzyme inhibitor paves way for new cancer drug
2. Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting
3. Novel mechanisms controlling insulin release and fat deposition discovered
4. Preliminary Results from Phase 2 Genzyme Study Highlight Potential of Novel Oral Compound for Gaucher Disease
5. Discovery of a novel mechanism for the development of colon cancer
6. TorreyPines Therapeutics Licenses Intellectual Property from Johns Hopkins Related to Novel Uses of Glutamate Receptor Antagonists for Prevention, Treatment of Stroke, Heart Attack
7. Latona Announces the Acquistion of Patent Rights and Orphan Drug Status to Novel Late Stage Drug Compound for Juvenile and Adult Rheumatoid Arthritis
8. Scientists identify novel way to prevent cardiac fibrosis
9. Registry unveils real-world data on novel excel stent
10. Researchers sharpen search for new marine medicines with novel techniques
11. Increased hepcidin expression: A novel oncogenic signalling mechanism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel toxin receptor discovered for ulcer-causing stomach pathogen
(Date:8/22/2014)... Las Vegas, NV (PRWEB) August 22, 2014 ... developed by Dr. Sen and Dr. Samantha Pearson to ... glasses, contacts, and avoid corrective vision surgery by instead ... Shane Michaels, prompting an investigative review. , “There’s ... billions of dollars in revenue each year—it’s because people ...
(Date:8/22/2014)... August 22, 2014 Testosterone treatment ... in U.S. courts on behalf of men who ... use of prescription low testosterone therapies, Bernstein Liebhard ... claim was filed against Pfizer Inc. on July ... life-threatening heart issues due to his use of ...
(Date:8/22/2014)... du Sac, Wisconsin (PRWEB) August 22, 2014 ... PFTape™ System for Plantar Fasciitis, an exciting new product ... product allows you to stay active while you heal. ... application. This is truly a new technology – it ... and affordable. , FasciaDerm® PFTape™ System for Plantar ...
(Date:8/22/2014)... The improved access to antiretroviral drugs and treatments ... has led to the decline in the rate of ... AIDS globally. However, despite the fact that HIV infection ... affected by the virus is on the rise. With ... organisations and stakeholders, by 2015, significant investments are expected ...
(Date:8/22/2014)... News) -- Back-to-school time provides an opportunity for parents ... family schedules, an expert suggests. "Forget New Year,s ... also be the start of a new fitness and ... kinesiology at the University of the Sciences in Philadelphia, ... extracurricular activities likely to build up, "it,s important for ...
Breaking Medicine News(10 mins):Health News:Restore My Vision Today: Review Exposes Natural Eye Restoration Guide by Dr. Sen and Dr. Samantha Pearson 2Health News:Testosterone Treatment Lawsuit News: New Filing Alleges Depo-Testosterone Caused Life-Threatening Heart Problems, Bernstein Liebhard LLP reports. 2Health News:Testosterone Treatment Lawsuit News: New Filing Alleges Depo-Testosterone Caused Life-Threatening Heart Problems, Bernstein Liebhard LLP reports. 3Health News:Testosterone Treatment Lawsuit News: New Filing Alleges Depo-Testosterone Caused Life-Threatening Heart Problems, Bernstein Liebhard LLP reports. 4Health News:Mueller Introduces FasciaDerm® PFTape™ System for Plantar Fasciitis 2Health News:Worldwide HIV Infection Drug Market Examined in New Kuick Research Report Published at MarketPublishers.com 2Health News:Worldwide HIV Infection Drug Market Examined in New Kuick Research Report Published at MarketPublishers.com 3Health News:With Kids in School, Parents Can Work Out 2
... HealthDay Reporter , WEDNESDAY, Jan. 5 (HealthDay News) ... with standard care, omega-3 fatty acid supplements appear to ... "Adding n-3 polyunsaturated fatty acids, even in patients ... a further improvement in heart function and exercise capacity," ...
... WEDNESDAY, Jan. 5 (HealthDay News) -- Women with multiple sclerosis ... a gene thought to be connected to the condition, a ... gain more insight into the development of MS, which is ... women. Although no one knows what causes MS, scientists suspect ...
... By Alan Mozes HealthDay Reporter , ... suggests that cocaine addiction might be treatable with a ... common cold virus in combination with a cocaine-like substance ... vaccine appears to provoke an effective and long-lasting antibody ...
... RI When methicillin-resistant S. aureus (MRSA) is ... for an invasive infection, including a surgical site infection. Some ... in the nose, the greater the risk of transmission to ... Few studies to date have assessed the differences in quantity ...
... 2011A new, simplified method for producing large amounts of ... cells will help advance the promising field of gene ... human clinical trials. The novel adeno-associated virus (AAV) production ... ahead of publication in Human Gene Therapy , ...
... News) -- Stress can cause even a healthy cat to ... researchers found that healthy cats were just as likely as ... waste outside their litter box if there was a change ... or caretaker. The healthy cats were compared to cats ...
Cached Medicine News:Health News:Fish Oil May Help Some Heart Failure Patients 2Health News:Fish Oil May Help Some Heart Failure Patients 3Health News:Study Sheds Light on Genetic Risk of MS 2Health News:Vaccine Protects Mice From Cocaine's Effects, Study Finds 2Health News:Vaccine Protects Mice From Cocaine's Effects, Study Finds 3Health News:Where MRSA colonizes on the human body 2Health News:Faster, scalable method for producing AAV-based gene transfer vectors 2
(Date:8/21/2014)... , Aug. 21, 2014  IBM (NYSE: IBM ... ( DESY ), a leading national research center in ... and storage of massive volumes of x-ray data. The ... on IBM software defined technology can handle more than ... and help scientists worldwide gain faster insights into the ...
(Date:8/21/2014)... -- Seventy-one percent of Americans believe the abuse of strong prescription ... and safety issue in the United States ... Repass & Partners, a Cincinnati based ... of the prescription medication abuse problem and the need for ... situation facing our country," Rex Repass , CEO of ...
(Date:8/21/2014)... BreedIT Corp., (OTCQB: BRDT) ... worldwide license holder and distributor of highly sophisticated ... today is pleased to announce the formation of ... a leading Israeli medical Cannabis breeder. ... breeds of medical Cannabis to meet the requests ...
Breaking Medicine Technology:DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3Consumers Desperate For Measures To Curb Prescription Drug Abuse 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 4
... Health Organization has issued a warning to medical travelers: ... heels of a growing threat of an antibiotic-resistant superbug, ... the region in India where it was discovered. "Many ... or knee replacements, ACL surgeries, root canals and spinal ...
...  Neuro Kinetics, Inc. (NKI) ( www.neuro-kinetics.com ), manufacturers ... test for vestibular and neurological conditions, said today ... control and analysis software at the upcoming annual ... Boston ( http://am2010.entnet.org/ ). NKI will ...
Cached Medicine Technology:New York Plastic Surgery News: Medical Tourists Beware of Drug-Resistant Superbug NDM-1 2Neuro Kinetics to Showcase Enhanced Control & Analysis Software at Otolaryngology Conference 2
... Finnpipette BioControl multichannel has ... as the single channel ... fits all seven multichannel ... tip cone modules. Both ...
... The Research pro Electronic Pipette is ... the laboratory. Its easy-to-follow display, ergonomically-placed operating ... pipetting, dispensing, reverse pipetting and diluting make ... the simple functions of a manual pipette ...
... The Research pro Electronic Pipette is ideal ... laboratory. Its easy-to-follow display, ergonomically-placed operating buttons, ... dispensing, reverse pipetting and diluting make this ... simple functions of a manual pipette without ...
... a 384 Well Plate at Once , To ... you need a pipettor that can adapt to ... get with our 16-channel Impact pipettor., Available with ... was specifically designed to allow you to transfer ...
Medicine Products: