Navigation Links
Novel toxin receptor discovered for ulcer-causing stomach pathogen
Date:5/23/2008

rily of lipids and proteins and are designed to keep things out. Some molecules can penetrate them, but most can do so only after binding to a specific membrane component, called a receptor. Receptors sometimes act as keys that open channels through a membrane, or they function as signaling molecules, communicating to other components in the cell.

Blankes team knew that VacA was latching on to something on the cell surface that was helping it across the membrane.

Other studies had shown that VacA bound to lipids within artificially created membranes, so graduate students Vijay Gupta and Hetal Patel screened a number of lipids for VacA binding and soon found one to which the toxin readily attached. This lipid, called sphingomyelin, is an important and abundant component of the membrane of some animal cells. (Foods such as milk, meat, fish and eggs are dietary sources of sphingomyelin.)

To be considered a receptor, a molecule must meet two criteria, Blanke said. It must bind the agent of interest (in this case VacA) to the cell surface, and it must confer sensitivity to that agent. In other words, a receptor to VacA must be essential to the process by which VacA gets into a cell. If you removed the receptor, or blocked it, the toxin would lose its ability to bind or function. Prior to this study, no molecules on the membrane of human cells had been found that satisfied both criteria as a receptor.

Upon entering cells, VacA spurs the formation of giant vacuoles. These oversized membrane-bound compartments are easy to spot under a microscope and provide a useful indicator of VacA activity in the cell.

To test whether sphingomyelin was a receptor for VacA, Gupta treated cultured human cells with an enzyme that depleted the membranes of sphingomyelin. In the sphingomyelin-depleted cells, the toxin lost its ability to cross into the cells and the giant vacuoles disappeared. When he restored sphingomyelin to the same cell membra
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Novel enzyme inhibitor paves way for new cancer drug
2. Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting
3. Novel mechanisms controlling insulin release and fat deposition discovered
4. Preliminary Results from Phase 2 Genzyme Study Highlight Potential of Novel Oral Compound for Gaucher Disease
5. Discovery of a novel mechanism for the development of colon cancer
6. TorreyPines Therapeutics Licenses Intellectual Property from Johns Hopkins Related to Novel Uses of Glutamate Receptor Antagonists for Prevention, Treatment of Stroke, Heart Attack
7. Latona Announces the Acquistion of Patent Rights and Orphan Drug Status to Novel Late Stage Drug Compound for Juvenile and Adult Rheumatoid Arthritis
8. Scientists identify novel way to prevent cardiac fibrosis
9. Registry unveils real-world data on novel excel stent
10. Researchers sharpen search for new marine medicines with novel techniques
11. Increased hepcidin expression: A novel oncogenic signalling mechanism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel toxin receptor discovered for ulcer-causing stomach pathogen
(Date:7/25/2014)... According to the Liver Cirrhosis ... Vkool.com, this is a comprehensive guide that provides ... safe remedies for liver cirrhosis . This ...     Chapter 1: Liver Cirrhosis Bible & ... About Liver Basics ,     Chapter 3: Getting ...
(Date:7/24/2014)... (PRWEB) July 25, 2014 Journal ... be affected by the width of the alveolar ridge—an ... the implant. A variety of methods exist, each with ... augmentation techniques. The ridge-split graft is highlighted as a ... Journal of Oral Implantology offers a comparison of ...
(Date:7/24/2014)... PROVIDENCE, R.I. [Brown University] The U.S. Preventive ... lung screening for people at high risk for ... that many patients will have positive results on ... on further testing. Many policymakers have expressed concern ... to become needlessly upset. A new study of ...
(Date:7/24/2014)... Voted one of the most reliable online ... focuses on providing its new and old customers with ... company has announced its new collection of high end ... created according to the latest fashion trends. Additionally, they ... off. , As a matter of fact, high end ...
(Date:7/24/2014)... 24, 2014 Four Seasons Resort ... of its $3 million renovation of the famed Maile ... three-bedroom suites, just in time to welcome summer guests ... design direction from the internationally-acclaimed BraytonHughes Design Studios, San ... the property and the largest in Hawaii—received a complete ...
Breaking Medicine News(10 mins):Health News:Liver Cirrhosis Bible & Ezra Protocol Review Exposes Debra Elkin's Liver Cirrhosis Treatment Guide – Vkool - Better Information, Better Lives 2Health News:Liver Cirrhosis Bible & Ezra Protocol Review Exposes Debra Elkin's Liver Cirrhosis Treatment Guide – Vkool - Better Information, Better Lives 3Health News:A Comparison of Graft Techniques for the Alveolar Ridge Prior to Oral Implant 2Health News:A Comparison of Graft Techniques for the Alveolar Ridge Prior to Oral Implant 3Health News:Informed consent: False positives not a worry in lung cancer study 2Health News:Informed consent: False positives not a worry in lung cancer study 3Health News:BellasDress Helps Brides Get High End Wedding Dresses for Their Romantic Weddings 2Health News:Four Seasons Resort Maui's Newly Designed Top Suites Debut 2Health News:Four Seasons Resort Maui's Newly Designed Top Suites Debut 3Health News:Four Seasons Resort Maui's Newly Designed Top Suites Debut 4Health News:Four Seasons Resort Maui's Newly Designed Top Suites Debut 5
... reporting assembly of the first functioning prototype of an ... process and package hormones, enzymes, and other substances that ... could lead to a faster and safer method for ... the researchers note. Their study is scheduled for the ...
... of the remains of a Tyrannosaurus rex (T. rex) ... protein from blood and bone, tendons, or cartilage. The findings, scheduled ... Journal of Proteome Research , is the latest addition to an ... dino. In the study, Marshall Bern, Brett S. Phinney and ...
... , , ... , , PRINCETON, N.J., July ... patient health and well-being, mentor less experienced staff, maintain institutional ... ages, creating a greater demand for hospital care, retaining veteran ...
... , , WASHINGTON , ... leading not-for-profit health plan and health care provider, received a 2009 ... and Prevention for its groundbreaking obesity prevention efforts. The award ... Washington, D.C., the CDC,s inaugural conference on obesity prevention and control. ...
... , WASHINGTON, July 29 Eight organizations were ... Control and Prevention (CDC) Weight of the Nation Conference in Washington, ... advancing policies and environmental strategies to prevent and control obesity. , ... particularly those from certain racial and ethnic groups, the CDC recognizes ...
... , , , BETHLEHEM, Pa., ... it has entered a new agreement with B. Braun ... (Logo: http://www.newscom.com/cgi-bin/prnh/20081022/NYW008LOGO ) , , ... members , B. Braun,s award winning Introcan Safety(R) IV Catheter ...
Cached Medicine News:Health News:New Study Identifies Strategies to Retain Experienced Nurses as Nursing Shortage Looms & Nation's Health Care Needs Grow 2Health News:New Study Identifies Strategies to Retain Experienced Nurses as Nursing Shortage Looms & Nation's Health Care Needs Grow 3Health News:New Study Identifies Strategies to Retain Experienced Nurses as Nursing Shortage Looms & Nation's Health Care Needs Grow 4Health News:New Study Identifies Strategies to Retain Experienced Nurses as Nursing Shortage Looms & Nation's Health Care Needs Grow 5Health News:New Study Identifies Strategies to Retain Experienced Nurses as Nursing Shortage Looms & Nation's Health Care Needs Grow 6Health News:Kaiser Permanente Honored for Efforts to Combat Obesity With 2009 Pioneering Innovation Award at Weight of the Nation Conference 2Health News:Kaiser Permanente Honored for Efforts to Combat Obesity With 2009 Pioneering Innovation Award at Weight of the Nation Conference 3Health News:Kaiser Permanente Honored for Efforts to Combat Obesity With 2009 Pioneering Innovation Award at Weight of the Nation Conference 4Health News:CDC Recognizes Innovative Obesity Prevention and Control Initiatives With Weight of the Nation Awards 2Health News:CDC Recognizes Innovative Obesity Prevention and Control Initiatives With Weight of the Nation Awards 3Health News:CDC Recognizes Innovative Obesity Prevention and Control Initiatives With Weight of the Nation Awards 4Health News:New Agreement Between Amerinet and B. Braun 2
(Date:7/24/2014)... , July 24, 2014  Restore Health, a ... compounded pharmaceuticals, announced that it is now offering ... to each individual based upon their particular genetic ... understanding the interaction between a patient,s genetics and ... very excited to provide this new service to ...
(Date:7/24/2014)... Inc. (NASDAQ: UPI ), a medical device ... products to treat voiding dysfunctions, today reported financial ... 30, 2014.  Global revenue for the ... to $4.1 million, as compared to $3.4 million ... Total revenue for the fiscal first quarter of ...
(Date:7/24/2014)... 2014  IRIDEX Corporation (NASDAQ: IRIX ) ... 2014 financial results after the market closes on ... release, the Company will host a conference call with ... on Thursday, July 31, 2014 to ... developments. Interested parties may access the live ...
Breaking Medicine Technology:Restore Health Launches Pharmacogenetic Testing, Enhancing Its Suite of Personalized Medicine Goods and Services 2Restore Health Launches Pharmacogenetic Testing, Enhancing Its Suite of Personalized Medicine Goods and Services 3Uroplasty Reports Fiscal First Quarter Results 2Uroplasty Reports Fiscal First Quarter Results 3Uroplasty Reports Fiscal First Quarter Results 4Uroplasty Reports Fiscal First Quarter Results 5Uroplasty Reports Fiscal First Quarter Results 6Uroplasty Reports Fiscal First Quarter Results 7Uroplasty Reports Fiscal First Quarter Results 8Uroplasty Reports Fiscal First Quarter Results 9Uroplasty Reports Fiscal First Quarter Results 10Uroplasty Reports Fiscal First Quarter Results 11
... N.Y., Sept. 29 International Business ... (MHIN) will jointly present the 7th Annual MidAmerica ... Wisconsin Technology Council. The conference brings together ... corporate business development executives, angel investors, investment bankers, ...
... Aesthetics, a science-based medical device company dedicated to the development ... has announced the appointment of Gordie Nye as ... founder of Zeltiq Aesthetics, who served as President since September ... the Board of Directors since 2006. Mr. Levinson will ...
Cached Medicine Technology:Announcing Companies to Present at the 7th Annual MidAmerica Healthcare Venture Forum 2Announcing Companies to Present at the 7th Annual MidAmerica Healthcare Venture Forum 3Announcing Companies to Present at the 7th Annual MidAmerica Healthcare Venture Forum 4Zeltiq Aesthetics Names Gordie Nye to Serve as New CEO 2Zeltiq Aesthetics Names Gordie Nye to Serve as New CEO 3
... is the premium CPAP device in ResMeds new ... line of flow generators are the smallest on ... to include an option of fully integrated heated ... for simplicity and convenience. Premium S8 models also ...
... freedom and flexibility with the integrated ... battery pack, the system will be ... Also includes an integrated heated humidifier. ... water for one nights use, and ...
... is the smallest and lightest continuous positive ... It is designed to help active sleep ... with therapy. The GoodKnight 420S model records ... data. It also detects persistent residual apnea, ...
The clarity and performance of glass with shatterproof safety of plastic....
Medicine Products: