Navigation Links
Novel toxin receptor discovered for ulcer-causing stomach pathogen
Date:5/23/2008

rily of lipids and proteins and are designed to keep things out. Some molecules can penetrate them, but most can do so only after binding to a specific membrane component, called a receptor. Receptors sometimes act as keys that open channels through a membrane, or they function as signaling molecules, communicating to other components in the cell.

Blankes team knew that VacA was latching on to something on the cell surface that was helping it across the membrane.

Other studies had shown that VacA bound to lipids within artificially created membranes, so graduate students Vijay Gupta and Hetal Patel screened a number of lipids for VacA binding and soon found one to which the toxin readily attached. This lipid, called sphingomyelin, is an important and abundant component of the membrane of some animal cells. (Foods such as milk, meat, fish and eggs are dietary sources of sphingomyelin.)

To be considered a receptor, a molecule must meet two criteria, Blanke said. It must bind the agent of interest (in this case VacA) to the cell surface, and it must confer sensitivity to that agent. In other words, a receptor to VacA must be essential to the process by which VacA gets into a cell. If you removed the receptor, or blocked it, the toxin would lose its ability to bind or function. Prior to this study, no molecules on the membrane of human cells had been found that satisfied both criteria as a receptor.

Upon entering cells, VacA spurs the formation of giant vacuoles. These oversized membrane-bound compartments are easy to spot under a microscope and provide a useful indicator of VacA activity in the cell.

To test whether sphingomyelin was a receptor for VacA, Gupta treated cultured human cells with an enzyme that depleted the membranes of sphingomyelin. In the sphingomyelin-depleted cells, the toxin lost its ability to cross into the cells and the giant vacuoles disappeared. When he restored sphingomyelin to the same cell membra
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

1

GOOD

Page: 1 2 3

Related medicine news :

1. Novel enzyme inhibitor paves way for new cancer drug
2. Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting
3. Novel mechanisms controlling insulin release and fat deposition discovered
4. Preliminary Results from Phase 2 Genzyme Study Highlight Potential of Novel Oral Compound for Gaucher Disease
5. Discovery of a novel mechanism for the development of colon cancer
6. TorreyPines Therapeutics Licenses Intellectual Property from Johns Hopkins Related to Novel Uses of Glutamate Receptor Antagonists for Prevention, Treatment of Stroke, Heart Attack
7. Latona Announces the Acquistion of Patent Rights and Orphan Drug Status to Novel Late Stage Drug Compound for Juvenile and Adult Rheumatoid Arthritis
8. Scientists identify novel way to prevent cardiac fibrosis
9. Registry unveils real-world data on novel excel stent
10. Researchers sharpen search for new marine medicines with novel techniques
11. Increased hepcidin expression: A novel oncogenic signalling mechanism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel toxin receptor discovered for ulcer-causing stomach pathogen
(Date:6/17/2013)... Vince Del Monte and Ben Pakulski are running a ... and it will only be around for the next 4 days. ... has released an updated Hypertrophy Max review to help people understand ... review here . , Davids says, "Vince Del Monte and Ben ... day sale as an extra incentive for people to take action. ...
(Date:6/17/2013)... helped to boost organ donor registration rates, according to ... of Transplantation . The findings suggest that social media ... of problems related to public health in which communication ... in the United States have remained static while increasing ... To provide organs to the more than 100,000 patients ...
(Date:6/17/2013)... Nearly 26 million adults have diabetes in ... adults are estimated to have pre-diabetes. The physicians' at ... through weight loss and lifestyle changes. Losing just 5 ... sugar level back within the normal range. Taking into ... Loss physicians can help tailor a diabetes diet plan ...
(Date:6/17/2013)... Park City, Utah (PRWEB) June 17, 2013 ... information on stand-alone HRAs for small businesses ... alternatives to traditional employer sponsored health benefits, is ... health reimbursement arrangements . , According to ... called Health Reimbursement Accounts or HRAs, offer small ...
(Date:6/17/2013)... Chile (PRWEB) June 17, 2013 Ayurveda ... means in sanscrit "knowledge or wisdom of life." As a ... spirit and the transformation of consciousness. Its fundamental philosophy is ... harmony with our environment. In order to re-establish optimal health, ... and then adopt a life style which brings us back ...
Breaking Medicine News(10 mins):Health News:Updated Hypertrophy Max Review Released for Vince Del Monte and Ben Pakulski's Hypertrophy Max Training Program 2Health News:Social media initiative may help increase organ donations 2Health News:Best Diet Plans for Diabetics; Tips from 101 Medical Weight Loss 2Health News:Best Diet Plans for Diabetics; Tips from 101 Medical Weight Loss 3Health News:Best Diet Plans for Diabetics; Tips from 101 Medical Weight Loss 4Health News:Zane Benefits Publishes New Information on Stand-Alone HRAs for Small Businesses 2Health News:Ayurveda Chile Program Offered by Escuela Ayurveda de California in August, 2013 2
... Seagull Technology,Pty Ltd, has developed a non-invasive drug delivery ... Australia,s leading cause of,blindness and severe vision loss -- ... retina which affects one in seven people over,the age ... ultrasound (sound,waves) in a handheld device to send drugs ...
... the largest,provider of business services to orthodontic and ... by adding an experienced,marketing professional to its team. ... will work out of the company,s,Metairie office., ... our team to,provide our doctors creative cutting edge ...
... Runyon Cancer Research Foundation named 14 new Damon ... Committee review. The recipients of this prestigious, ... and translational cancer research in the laboratories of ... Fellowship is specifically intended to encourage the nation,s ...
... a woman,s eggs to deteriorate in quality with age, and ... choose an egg -- out of a stash of roughly ... the ovary be influenced to pick a "good" quality egg ... questions are much on the mind of fertility researcher Teresa ...
... vessels, researchers say , , THURSDAY, June 19 (HealthDay News) ... role in allowing experts to see the many reds, ... a report by researchers at the Massachusetts Institute of ... minor players in brain activity, receive signals directly from ...
... We Make A Life By What We Give is the ... about their lives and how they can share what they have ... and Riley Hospital for Children physician-philosopher Richard B. Gunderman, M.D., Ph.D. ... giving in their lives. , In the book, Dr. Gunderman expands ...
Cached Medicine News:Health News:Revolutionary Therapy: Needle-Free Technology for the Treatment Of Blinding Eye Disease 2Health News:Damon Runyon Cancer Research Foundation awards prestigious fellowships to 14 top young investigators 2Health News:Damon Runyon Cancer Research Foundation awards prestigious fellowships to 14 top young investigators 3Health News:Damon Runyon Cancer Research Foundation awards prestigious fellowships to 14 top young investigators 4Health News:New photo 'op' for ovaries may solve some mysteries of infertility 2Health News:Star-Shaped Brain Cells Make Scans Possible 2
(Date:6/17/2013)... Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: ... ENDO 2013, the Endocrine Society,s 95 th ... both melatonin and cortisol rhythms. This effect further ... clock and address the circadian desynchrony which is ... and Efficacy of Tasimelteon) and RESET (Randomized-withdrawal study ...
(Date:6/17/2013)... 17, 2013 Valeant Pharmaceuticals International, Inc. (NYSE: ... has filed a preliminary prospectus supplement to its effective shelf ... similar filing with securities regulatory authorities in each of the ... a public offering of its common shares to raise gross ... Company will also grant to the underwriters of the Offering ...
(Date:6/17/2013)... June 17, 2013 The following is a Statement ... at Drugfree.org :   Last Friday, ... was halting the sale of prescription drug paraphernalia products. The ... that from time to time there may be individual items ... As a result of this misinterpretation we are electing to ...
Breaking Medicine Technology:Vanda Presents Data From Phase III Studies that Demonstrate Tasimelteon Restores Daily Cortisol Rhythm In Blind Patients With Non-24-Hour Disorder 2Vanda Presents Data From Phase III Studies that Demonstrate Tasimelteon Restores Daily Cortisol Rhythm In Blind Patients With Non-24-Hour Disorder 3Vanda Presents Data From Phase III Studies that Demonstrate Tasimelteon Restores Daily Cortisol Rhythm In Blind Patients With Non-24-Hour Disorder 4Valeant Pharmaceuticals Announces Public Offering Of Common Shares 2Valeant Pharmaceuticals Announces Public Offering Of Common Shares 3Valeant Pharmaceuticals Announces Public Offering Of Common Shares 4A Win for Families: Urban Outfitters Halts Prescription Drug Paraphernalia Product Sales 2
... it has been selected as a Finalist ... list honoring the year,s most promising private technology ventures ... The Red Herring editorial team selected the most innovative ... America. The nominees are evaluated on both quantitative and ...
... a full-service pharmacy benefit management and ancillary medical ... Craig Rollins has joined the organization as Vice ... role he will be responsible for the strategic ... 1Click Ancillary online marketplace. myMatrixx launched 1Click Ancillary ...
Cached Medicine Technology:DICOM Grid Selected as a Finalist for the 2012 Red Herring Top 100 Americas Award 2myMatrixx Names Craig Rollins, Vice President of Ancillary and Business Development 2
... magnification and increased stereopsis, the Central Retinal ... to the equatorial regions. The Central Retinal ... in membrane peeling in proliferative vitreoretinopathy extending ... The ACS Vitrectomy Lenses from Volk can ...
... These patented ACS lenses offer the ... view as the original clariVits. The simple ... while maintaining its integrity during surgery. Simply ... contact element, then lock together for use. ...
... magnification, indirect, contact, vitrectomy lens available! ... the surgical management of macular holes, ... submacular surgery. The magnification of the ... of a plano/concave direct imaging vitrectomy ...
... XL is recommended for evaluating ... fundus and in the management ... the ideal lens for small ... operating microscope. It provides a ...
Medicine Products: