Navigation Links
Novel therapy for metastatic kidney cancer developed at VCU Massey Cancer Center
Date:12/15/2010

Richmond, Va. (Dec. 15, 2010) Researchers at Virginia Commonwealth University Massey Cancer Center and the VCU Institute of Molecular Medicine (VIMM) have developed a novel virus-based gene therapy for renal cell carcinoma that has been shown to kill cancer cells not only at the primary tumor site but also in distant tumors not directly infected by the virus. Renal cell carcinoma is the most common form of kidney cancer in adults and currently there is no effective treatment for the disease once it has spread outside of the kidney.

The study, published in the journal Cancer Biology & Therapy, tested Sorafenib (Nexavar), a drug approved by the FDA to treat kidney cancer, in conjunction with a novel adenovirus (Ad.5/3-mda-7). Adenoviruses are viruses known to infect the upper respiratory tract. But when used for therapeutic purposes, the virus' harmful genetic material is replaced with genetic code that activates biological processes within infected cells. The Ad.5/3-mda-7 adenovirus used in this study was engineered to cause kidney cancer cells and normal cells protecting the kidneys to express the cancer-killing protein MDA-7/IL-24. The therapy in this study was developed by Paul Dent, Ph.D., Universal Corporation distinguished professor in cancer cell signaling at VCU Massey and vice chair of the department of neurosurgery; and Paul B. Fisher, M.Ph., Ph.D., Thelma Newmeyer Corman endowed chair in cancer research at VCU Massey, professor and chair of the department of human and molecular genetics and director of VIMM; in collaboration with David T. Curiel, M.D., Ph.D., from the University of Alabama.

"While further research is needed, this therapy could be a novel and effective way to treat metastatic kidney cancer and prolong patient survival," says Dent. "This is the first study to clearly define that gene therapeutic delivery of MDA-7/IL-24 in kidney cancer should be explored in the clinic, especially since we've demonstrated an established, FDA-approved drug enhances its toxicity to cancer cells."

In mouse models, injection of the virus caused kidney cancer cells and normal cells lining the kidneys to secrete the protein MDA-7/IL-24. In the primary tumor site where the virus was first injected, the secreted MDA-7/IL-24 protein caused the tumor to stop growing. And once the protein entered the blood stream it stopped the growth of a second, distinct tumor not directly infected by the adenovirus, a result called a "toxic bystander effect." Normal cells were unaffected. Sorafenib, already approved by the FDA to treat renal carcinoma, enhanced MDA-7/IL-24 toxicity in the laboratory and significantly increased its anti-tumor effects in animal tumor models.

"Adenoviral gene therapies are still very new, but they represent a potentially powerful tool in the fight against cancer," says Fisher. "Our ultimate goal is to move our research from the laboratory to patients. And based on our findings, we hope these therapies will be effective against a variety of cancers."

The MDA-7/IL-24 gene was originally discovered by Fisher when he was a professor at Columbia University College of Physicians and Surgeons in New York. The current research was developed by Dent and Fisher at VCU Massey Cancer Center and the VIMM, and the method by which the virus infects the cancer cells was developed in collaboration with Curiel. The investigators hope to advance the research to a Phase I clinical trial on patients with metastatic kidney cancer, and also are investigating the use of MDA-7/IL-24 gene therapy on other diseases, including melanoma and brain, prostate, pancreatic, breast and colon cancers.


'/>"/>

Contact: John Wallace
wallacej@vcu.edu
804-628-1550
Virginia Commonwealth University
Source:Eurekalert

Related medicine news :

1. UCI researchers find novel memory-enhancing mechanism in brain
2. Novel imaging technique may reduce lymphedema in breast cancer patients
3. New standards of care and novel treatment options for several forms of lymphoma unveiled
4. Novel genetic mutation that causes the most common form of eye cancer discovered
5. Quebec City researchers pave the way for novel treatment of pulmonary hypertension
6. Eat safer: Novel approach detects unknown food pathogens
7. Novel Drug Eases Osteoarthritis Knee Pain
8. Novel biomarker may predict response to new VEGF receptor inhibitor
9. Novel Rheumatoid Arthritis Drug Shows Early Promise
10. Novel target for existing drug may improve success of radiation therapy
11. Novel nanotechnology collaboration leads to breakthrough in cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm ... sciences executive with extensive sequencing and genomics experience, as Vice President of North American ... Hill will be responsible for leading the sales team in the commercialization of the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Today, MTI-GlobalStem, a provider ... and other difficult to transfect cells, announces its launch of the PluriQ™ G9™ ... Editing System is a complete system for culturing and transfecting human pluripotent ...
(Date:6/24/2016)... Palm City, FL (PRWEB) , ... June 24, 2016 , ... ... and inflammation common after venous procedures, dermaka cream can be incorporated into the post-surgical ... peels, and minor surgical procedures. , dermaka cream is very effective for bruising ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Randall Markarian, DDS, are co-chairs for the Illinois State Dental Society (ISDS) ... July 15-16 at the Gateway Convention Center in Collinsville. , They ...
(Date:6/24/2016)... ... June 24, 2016 , ... SpiritQuest Sedona Retreats, located ... West Sedona, surrounded by famous vortex sites: Cathedral Rock, Airport Mesa, and Boynton Canyon. ... – the Lodge at Sedona as well as the Sedona Rouge, both popular accommodations ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
(Date:6/23/2016)... , June 23, 2016 Research ... Pharma News Issue 52" report to their offering. ... in influenza treatment creates a favourable commercial environment for MedImmune ... growing patient base that will serve to drive considerable growth ... vaccine would serve to cap sales considerably, but development is ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at www.diabetesscholars.org by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
Breaking Medicine Technology: