Navigation Links
Novel therapeutic agents provide hope for patients with hard-to-treat blood disorders
Date:12/9/2012

>Despite this success, no targeted treatment option exists for approximately5 to 20 percent of CML and Ph+ALL patients with the "gatekeeper" T3151 BCR-ABL mutation, which makes them resistant to available TKIs. The only treatment alternative is a hematopoietic stem cell transplant which has toxic side effects. Ponatinib, the first targeted therapy that has emerged for these hard-to-treat patients, has demonstrated excellent activity against the T3151 mutation in early clinical trials. High levels of response have also been observed in patients with other mutations or with no mutations who have experienced resistance or intolerance to two or all three available TKIs. Given these promising results, researchers conducted a pivotal Phase II trial assessing the drug.

A team of researchers from the United States and Europe enrolled 449 patients with CML and Ph+ALL who were either resistant or intolerant (R/I) to dasatinib or nilotinib or had the T3151 mutation. Patients were assigned into six cohorts based on their disease resistance or genetic profile and then treated with ponatinib. Nearly all of the patients were previously treated with two of the available TKIs (imatinib, dasatinib, and/or nilotinib) or with all three TKIs. The primary endpoint of the study was major cytogenetic response (>65% of cells are normal) within 12 months of treatment for those with chronic phase CML and major hematologic response (normal white blood cell counts) within six months after treatment for those with advanced-phase CML or Ph+ALL.

Major cytogenetic response was observed in 55 percent of all chronic-phase CML patients (50% of R/I patients and 70% with T3151 mutation), and major hematologic response was observed in 58 percent of patients with accelerated-phase CML (57% of R/I patients and 50% with T3151 mutation) and 34 percent of those with blast-phase CML/ Ph+ALL (35% of R/I patients and 33% with T3151 mutation). The similar response rates observed in patients wit
'/>"/>

Contact: Andrea Slesinski
aslesinski@hematology.org
614-352-5096
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14

Related medicine news :

1. Researchers develop novel 3-D culture system for inflammatory breast cancer
2. ACNP: Novel NMDA receptor modulator significantly reduces depression scores within hours
3. Scripps Florida scientists uncover a novel cooperative effort to stop cancer spread
4. Novel mechanism through which normal stromal cells become cancer-promoting cells identified
5. Novel breast screening technology increases diagnostic accuracy
6. UNC, Vanderbilt discover a new live vaccine approach for SARS and novel coronaviruses
7. Moffitt Cancer Center researchers identify novel metabolic programs driving aggressive brain tumors
8. Novel treatment strategies for epilepsy
9. Taiho Pharmaceutical unveils data on 8 novel anticancer compounds
10. Researchers ID potential patient population who may benefit from novel anti-platelet treatment
11. Undertreatment of common heart condition persists despite rapid adoption of novel therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2015)... Manufacturers are now required to produce water heaters with ... in the field agree that the regulation is aimed at ... is what miles per gallon is to your car. The ... minimum HSPF score has been raised to 8.2, technology has ... of 12. Indeed, the regulation was welcomed by environmentalist, and ...
(Date:5/23/2015)... Baltimore, MD (PRWEB) May 23, 2015 Injury ... moratorium that has been passed by the Maryland legislature but ... , “The Maryland General Assembly passed HB 449 ... the Governor has not signed it into law. This bill ... 2017. Evidence is growing that demonstrates the danger of fracking ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 Mountain Point Medical ... a ribbon cutting ceremony on Friday, May 29, 2015 at ... to 6 p.m. The new medical center, set to officially ... Triumph Boulevard, Lehi, UT 84043. , “The opening of ... team and the Utah County community,” said Kent Loosle, CEO ...
(Date:5/22/2015)... 22, 2015 Omar Ahmad Barrada, a ... participate in the 2015 Congress of Future Medical Leaders ... a gathering of “America’s highest achieving high school students.” ... healthcare, set new goals and learn better study habits,” ... surgery, during which we can ask the surgeons questions.” ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 Family, friends, ... Hospital’s world-renowned surgical oncologist, Dr. LaSalle D. Leffall, on ... The luncheon began after Grand Rounds in the hospital’s ... waited anxiously outside the auditorium, trying to keep the ... but if he sees me, he’ll know something is ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Welcomes the Department of Energy’s Water Heater Regulation 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 3Health News:Mountain Point Medical Center, a Campus of Jordan Valley Medical Center, Hosts Ribbon Cutting Ceremony and Community Celebration on Friday, May 29, 2015 2Health News:Milton Hershey School Student Chosen for Congress of Future Medical Leaders 2Health News:Colleagues Surprise Dr. LaSalle Leffall with 85th Birthday Celebration 2
... Clinic Will Offer Assessments for Diabetic Retinopathy, a ... Leading Cause of ... Wake,Forest, NC company specializing in retinal risk assessment for diabetics,announced today ... solution to provide retinal imaging risk assessment., MacGregor Medical Center ...
... those living with food allergies, WHITE PLAINS, N.Y., ... from food allergies. For most, it means avoiding,certain foods ... even fatal,reactions., Now those with food allergies can ... re-positional Post-It(R) notes that help,alert others to an allergy ...
... Million Angelenos Within Three Years, LOS ANGELES, Nov. ... Villaraigosa today as he launched the City of Los,Angeles ... Angelenos,within the next three years. The Mayor tested for ... Gardens community to underscore the,importance of "early testing" within ...
... while in hospital as a result of their clinical care, suggests ... findings are based on a review of the case notes of ... large teaching hospital in the north of England during the first ... typical of other similar facilities, however, say the authors. , The ...
... BLU-MED Response Systems,announced today two new contract ... preparedness and surge capacity for hospitals and,public health ... District,Four and Suffolk County, NY., The first ... awarded by the Idaho Central District Health Department. ...
... has gone wrong , , FRIDAY, Nov. 30 (HealthDay News) -- ... millions of dollars have been poured into outreach efforts aimed at ... disease. , But on the eve of World AIDS Day, a ... newly infected teens and young adults is suddenly on the rise. ...
Cached Medicine News:Health News:Digital Healthcare Announces MacGregor Medical Center San Antonio to Utilize Retasure for Retinal Imaging Assessment 2Health News:AllerNotes Help Take Food Allergies Off the Table 2Health News:Mayor Antonio Villaraigosa Partners With AltaMed Health Services to Launch City of Los Angeles HIV Testing Initiative 2Health News:1 in 10 patients comes to harm while in hospital 2Health News:BLU-MED Announces New Medical Preparedness Contracts 2Health News:More Young Americans Are Contracting HIV 2Health News:More Young Americans Are Contracting HIV 3Health News:More Young Americans Are Contracting HIV 4Health News:More Young Americans Are Contracting HIV 5
(Date:5/22/2015)... ROCKVILLE, Md. , May 22, 2015  RegeneRx ... focused on tissue protection, repair and regeneration, today announced ... RegeneRx, is scheduled to present a corporate overview at ... will present at the SeeThruEquity 4 th Annual ... New York City at 11:00 am ...
(Date:5/22/2015)...  The Mesothelioma Victims Center is incredibly passionate ... the best possible compensation, and they are also extremely ... cancer caused by exposure to asbestos or their ... treatment options such as a recent possible medical breakthrough. ... Center anytime at 866-714-6466. http://MesotheliomaVictimsCenter.Com ...
(Date:5/22/2015)... May 22, 2015 Research and Markets ... of the "Latest Regulations on Pharmaceutical International ... their offering. This is first time ... guidance on international multi-center clinical trials of drugs ... begun to be implemented on March 1, 2015. ...
Breaking Medicine Technology:RegeneRx to Present at 2 Investor Conferences 2RegeneRx to Present at 2 Investor Conferences 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 2Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 4Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 52015 Regulations on Pharmaceutical International Multi-Center Clinical Trials in China 2
... Aethlon Medical, Inc. (OTCBB: AEMD), the ... infectious disease and cancer, announces that Chairman and ... overview, discuss recent developments and review upcoming milestones ... Technologies Virtual Conference.   (Photo:   ...
... Inc. (Nasdaq: MYL ) today announced that its ... U.S. Food and Drug Administration (FDA) for its Abbreviated New ... and 10 mg, the generic version of Eisai,s Aricept® Tablets, ... Donepezil HCl Tablets had U.S. sales of ...
Cached Medicine Technology:Aethlon Medical to Discuss Recent Progress at the LHA Life Sciences & Medical Technologies Virtual Conference on June 16 2Aethlon Medical to Discuss Recent Progress at the LHA Life Sciences & Medical Technologies Virtual Conference on June 16 3
... Eppendorf Reference Series 2000 Pipette is a ... a compact and robust design, and superior ... used to operate the measuring stroke and ... Product features:Eppendorf "pipette/tip" system ensures utmost accuracy ...
... Eppendorf Reference Series 2000 Pipette is a ... a compact and robust design, and superior ... used to operate the measuring stroke and ... Product features:Eppendorf "pipette/tip" system ensures utmost accuracy ...
... Eppendorf Reference Series 2000 Pipette is a ... a compact and robust design, and superior ... used to operate the measuring stroke and ... Product features:Eppendorf "pipette/tip" system ensures utmost accuracy ...
... Finnpipette Focus from Thermo Labsystems ... ergonomics with uncompromising performance. ... offers a custom fit for ... shorter tip cones allow easier ...
Medicine Products: