Navigation Links
Novel therapeutic agents provide hope for patients with hard-to-treat blood disorders
Date:12/9/2012

apy or Hematopoietic Stem Cell Transplantation [Abstract 673]

Research suggests that a new targeted therapy, quizartinib, may be a safe and effective option to treat a subset of patients with treatment-resistant acute myeloid leukemia (AML).

AML is a fast-growing blood cancer in which patients produce an excessive amount of abnormal, immature white blood cells that are unable to adequately fight infection. Following AML diagnosis, leukemia cells from patients undergo genetic testing to identify the mutation driving the disease, which helps determine the appropriate treatment protocol. Of the many types of genetic mutations that can occur in AML, one of the most threatening is the FLT3-ITD (internal tandem duplication), which makes the leukemia even more aggressive and typically leads to failure of standard chemotherapy treatment response.

"The FLT3 mutation is essentially a power switch that leukemia cells use to spread more aggressively, which helps them to grow back immediately after chemotherapy," said Mark J. Levis, MD, PhD, lead author and Associate Professor of Oncology, Pharmacology, and Medicine at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medicine in Baltimore. "The only way to treat this type of mutation is to find a way to turn the switch off a feat that has eluded researchers for far too long."

Patients with the FLT3-ITD mutation can achieve remission with standard chemotherapy but tend to relapse very quickly. An important treatment option is a stem cell transplant, but only if the patient is in some form of remission; otherwise, transplant failure rates are high. Given the barriers to treatment in this patient population, researchers have been examining the efficacy of the investigational oral agent quizartinib, which is designed to "turn off" the mutated FLT3 enzyme, thus forcing the immature cancer c
'/>"/>

Contact: Andrea Slesinski
aslesinski@hematology.org
614-352-5096
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14

Related medicine news :

1. Researchers develop novel 3-D culture system for inflammatory breast cancer
2. ACNP: Novel NMDA receptor modulator significantly reduces depression scores within hours
3. Scripps Florida scientists uncover a novel cooperative effort to stop cancer spread
4. Novel mechanism through which normal stromal cells become cancer-promoting cells identified
5. Novel breast screening technology increases diagnostic accuracy
6. UNC, Vanderbilt discover a new live vaccine approach for SARS and novel coronaviruses
7. Moffitt Cancer Center researchers identify novel metabolic programs driving aggressive brain tumors
8. Novel treatment strategies for epilepsy
9. Taiho Pharmaceutical unveils data on 8 novel anticancer compounds
10. Researchers ID potential patient population who may benefit from novel anti-platelet treatment
11. Undertreatment of common heart condition persists despite rapid adoption of novel therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... (PRWEB) December 26, 2014 Recently, iFitDress.com, the ... for women, has announced its new selection of black ... are on sale now; they are available at discounted prices, ... says, “The promotion will last for three weeks only. You ... market. Those who are interested in our new items can ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 The short film ... was created in honor of a true 9/11 hero, Welles ... film festivals including the 24 hours of Nuremberg International Short ... Bangladesh. , Actress, screenwriter and director Luciana Lagana ... this film together with her husband, Gregory Graham ...
(Date:12/25/2014)... BambooFlooringChina.com sells many bamboo products and the business ... company announces big discounts on its bamboo mats ... BambooFlooringChina.com is the world’s leader in bamboo flooring. According ... Jan. 20, 2015. , The bamboo mats are made ... thread. All the bamboo strips for the mats are ...
(Date:12/25/2014)... 25, 2014 When head lice hits a ... a frenzy to get rid of it while keeping it ... Coral Gables now have the solution right in their neighborhood: ... location, Lice Troopers provides full spectrum head lice screening and ... area, including Sunset, Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest ...
Breaking Medicine News(10 mins):Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2
... Plan focuses on added benefits to improve care ... with chronic health conditions -, LITTLE ROCK, ... Medicare annual enrollment period which begins November 15th, ... 2009 Special Needs Plan,(SNP) offerings for chronically ill ...
... Points to Need for a Federal Office of Men,s ... national,phone and direct mail effort, was administered to the ... Washington, D.C.) and,the Governor,s Office, where appropriate. The survey ... Meeting in San,Diego on October 26th, 2008 and are ...
... of the National Organization for Rare Disorders ... Compassionate Allowances,initiative "an outstanding achievement" that will ... The initiative announced today will fast-track applications ... of 25 rare diseases and 25,cancers whose ...
... NANJING, China, Oct. 27 /Xinhua-PRNewswire/ -- Simcere ... manufacturer and supplier of branded generic,pharmaceuticals and ... market, announced today its participation in the ... conference will be,held at the Grand Hyatt ...
... led by UBC Psychiatry Prof. Weihong Song, who is also ... Disease at UBC, found that if Valproic Acid (VPA) is ... deficit is reversed. , The study, published in the Journal ... activity of an enzyme that produces a neurotoxic protein called ...
... Readers to Meaningful Coincidences, LOUISVILLE, Colo., Oct. ... Clearly Now: How Synchronicity Illuminates Our,Lives, has been ... in both Best New,Non-Fiction and Best New Age ... USABookNews.com, the premiere online magazine and review ...
Cached Medicine News:Health News:Care Improvement Plus Launches 2009 Benefits in Arkansas 2Health News:New State Public Health Department Survey Results Highlight Available Resources for Men and Women 2Health News:New Compassionate Allowances for Social Security Disability Represent 'Outstanding Achievement,' NORD Says 2Health News:Simcere Pharmaceutical Group to Participate in Goldman Sachs China Investment Frontier Conference 2008 2Health News:New Author Mary Soliel Honored as Two-time National Best Books 2008 Award Finalist 2
(Date:12/24/2014)... , Dec. 23, 2014   Assurex Health, ... support to healthcare providers for behavioral health and ... secured $30 million in equity financing from new ... Drosos , President and Chief Executive Officer. ... and development of Assurex Health,s GeneSight ® ...
(Date:12/24/2014)... , Dec. 23, 2014 Tianyin ... company that specializes in patented biopharmaceutical, modernized traditional ... ingredients (API) today announced that the Company achieved ... Good Manufacturing Practice (GMP) certificate of TPI,s Qionglai ... Administration,s (CFDA). The public notice period is a ...
(Date:12/24/2014)...  Medical Science Liaisons play a large role in ... medical device industry and key stakeholders, the role of ... as the device industry relies on them to build ... benchmarking firm, Best Practices, LLC, one area where Medical ... by harnessing new technology to enable education. Online conferences ...
Breaking Medicine Technology:Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3Role of Medical Science Liaisons Evolving in Medical Device Sector 2
... 21, 2010 Reportlinker.com announces that a new ... Thai Self-monitoring of Blood Glucose ... http://www.reportlinker.com/p0350305/Thai-Self-monitoring-of-Blood-Glucose-SMBG-Devices-and-Strips-Market.html This Market Engineering ... dynamics of blood glucose monitoring device sales and ...
... 2010 The American Veterinary Medical Association (AVMA) has offered ... on a useful and effective induction agent, propofol. ... Schedule IV drug.  In a letter to the DEA today, ... this effective drug, which typically causes few side effects when ...
Cached Medicine Technology:AVMA Offers Important Guidance to DEA on New Controls for Induction Agent—Propofol 2
... The OcuLight family of infrared laser photocoagulators ... models. These diode lasers serve as a ... and applications, require no regular maintenance or ... their compact design. The OcuLight SLx is ...
... Using the latest in solid-state technology, ... green light at 532 nm. Patented ... delivery device options maximize versatility, compact ... and advanced design minimizes any routine ...
... Danker Laboratories manufacturers a ... orthokeratology lenses (also known ... "Corneal Reshaping" Lenses) according ... and demanding standards of ...
... The Euclid Systems Orthokeratology (oprifocon A) ... contact lenses used for orthokeratology, a ... The patient wears these lenses overnight ... During the day, nearsightedness is temporarily ...
Medicine Products: