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Novel therapeutic agents provide hope for patients with hard-to-treat blood disorders
Date:12/9/2012

low patients the convenience of a completely oral, highly effective regimen for treatment of multiple myeloma."

Dr. Kumar will present this study in an oral presentation on Monday, December 10, at 7:15 a.m. EST at the Georgia World Congress Center in the Thomas Murphy Ballroom 2-3, Level 5, Building B.

Pomalidomide in Combination with Low-Dose Dexamethasone: Demonstrates a Significant Progression Free Survival and Overall Survival Advantage, in Relapsed/Refractory MM: A Phase III, Multicenter, Randomized, Open-Label Study [LBA 6]

An advanced trial comparing therapeutic options for refractory multiple myeloma finds that combination treatment with pomalidomide and low-dose dexamethasone may be superior to high-dose dexamethasone alone for patients with resistant and relapsed disease.

Multiple myeloma (MM) causes abnormal plasma cells to accumulate in the bone marrow, interfering with normal blood cell production and increasing the risk of infection and abnormal bleeding. Current treatments include combinations of steroid therapies like dexamethasone, which reduces inflammation and manages the immune response with targeted therapies like bortezomib and lenalidomide that inhibit tumor growth and reproduction. However, many patients eventually become resistant to these standard therapies and therefore have a poor prognosis. Since there are few treatment options available for these difficult-to-treat patients, research has aimed to identify new therapy combinations and disease targets that may lead to better results.

Early trials of a novel immunomodulatory drug called pomalidomide have shown some evidence of activity in these relapsed and treatment-resistant patients. Pomalidomide offers an effective mechanism against resistant myeloma because it directly targets the disease in multiple ways. It not only encourages the immu
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Contact: Andrea Slesinski
aslesinski@hematology.org
614-352-5096
American Society of Hematology
Source:Eurekalert

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