Navigation Links
Novel therapeutic agents provide hope for patients with hard-to-treat blood disorders
Date:12/9/2012

Phase I/II study and administered an oral dose of the proteasome inhibitor combined with lenalidomide and dexamethasone for up to 12, 28-day cycles, followed by maintenance therapy with MLN9708 every 28 days until disease progression. Primary objectives in Phase I included safety, maximum tolerated dose, and recommended Phase II dose. In Phase II, primary objectives included complete remission and very good partial response (VGPR, measured by a 90% or greater reduction in abnormal myeloma proteins in the blood).

In Phase I, the maximum tolerated dose was determined as 2.97 mg/m2 and recommended Phase II dose was selected as 2.23 mg/m2, which was later converted to a 4.0 mg/m2 dose based on encouraging results related to the body's ability to tolerate the drug. In Phase II, the investigators observed an overall response rate of 92 percent with 55 percent of patients reaching VGPR or better, including 23 percent with a complete remission. As the treatment cycles progressed, the rate and depth of response increased.

Minor adverse events, such as fatigue, nausea, and rash, were noted in approximately 40 percent of patients. Serious adverse events were minimal and primarily consisted of decreased blood counts, nausea and vomiting, diarrhea, rash, and electrolyte disturbances. One patient died from pneumonia while on treatment, and seven patients discontinued treatment due to different side effects.

"As targeted therapies continue to evolve, we are now shifting our efforts to focus on making them safer and producing them in more convenient forms for patients. MLN9708 is a great example of how to accomplish this goal," said Shaji K. Kumar, MD, lead author and Professor of Medicine and Consultant in Hematology at the Mayo Clinic in Rochester, Minn. "We are now planning ongoing studies to examine this drug in combination with other myeloma drugs in Phase II and Phase III clinical trials. Once approved for treatment of myeloma, this drug will al
'/>"/>

Contact: Andrea Slesinski
aslesinski@hematology.org
614-352-5096
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14

Related medicine news :

1. Researchers develop novel 3-D culture system for inflammatory breast cancer
2. ACNP: Novel NMDA receptor modulator significantly reduces depression scores within hours
3. Scripps Florida scientists uncover a novel cooperative effort to stop cancer spread
4. Novel mechanism through which normal stromal cells become cancer-promoting cells identified
5. Novel breast screening technology increases diagnostic accuracy
6. UNC, Vanderbilt discover a new live vaccine approach for SARS and novel coronaviruses
7. Moffitt Cancer Center researchers identify novel metabolic programs driving aggressive brain tumors
8. Novel treatment strategies for epilepsy
9. Taiho Pharmaceutical unveils data on 8 novel anticancer compounds
10. Researchers ID potential patient population who may benefit from novel anti-platelet treatment
11. Undertreatment of common heart condition persists despite rapid adoption of novel therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... "I recognized the need for a better ... an inventor from Cincinnati, Ohio. "This need inspired me ... the Slyde Door to offer an alternative to the ... provides convenient storage space for an evacuation stretcher. The ... patients. , This offers added peace of mind ...
(Date:4/18/2015)... Lower-auto-insurance.com has released a new blog post explaining how ... , Drivers can find accurate information about various ... brokerage website can help drivers compare the newest and ... The whole process is designed to be convenient, free ... insurance quotes is advantageous because it allows clients to ...
(Date:4/18/2015)... New York, NY (PRWEB) April 18, 2015 ... their Internal Security Threat Report , which they say, “exposes ... on how many new malware variants were introduced in 2014 ... it took for Zero Day threats to be identified and ... – it is abundantly clear that doing business in a ...
(Date:4/17/2015)... 18, 2015 Heritage Woods of McLeansboro, ... Supportive Living Week Celebration on April 20 with a ... healthy mind, body and soul. , The community, which ... serves older adults of all incomes, including those on ... , Supportive Living Week is observed every April and ...
(Date:4/17/2015)... April 17, 2015 Alcohol and Violence ... (NCADD) notes that drinking and driving has been the ... the same time, the link between alcohol and crime ... abuse and violence and sexual assault, and their relationship ... the NCADD, 5.3 million adults in America were drinking ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Quotes Can Provide Accurate Results! 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 3Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 4Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 5Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 3Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 2Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 3
... for every four adults in the world who are ... obese.// ,Obesity which brings in several health ... says that although it is more prevalent in some ... ,Statistics show that a billion people of ...
... plastic pill which has been found to fight plaque and gum ... pain and swelling just by its position between the threatened tooth ... University of New Jersey, who have tested the pill on animals, ... gum and bone to heal as well as regenerate. ...
... vitamin B12 deficiency manifest themselves as depression, sleeplessness, numbness, ... taken as signs of mental decline. In elderly people ... ,Vegetarians are particularly at risk of developing the ... They must ensure that they take a supplement. The ...
... Health Ministry had suspended flu vaccine administration on Sunday ... to// the Israeli media, the fourth death was reported later. ... are connected to the vaccines,' said Inbal Jacobs, a ministry ... in the last few days were from a southern Israeli ...
... college students put on several pounds in their freshman year. Freshman ... average of 15// pounds in their freshman year. Though this may ... ,The first study was conducted on 907 students at ... results, both girls and guys gained an average of 7.8 pounds ...
... reinforced by a study, eating your vegetables is a habit ... of eating// vegetables like spinach and lettuce, carrots and ... ,The study was conducted by Susanna C. Larsson ... Institute in Sweden. The team wanted to determine the link ...
Cached Medicine News:Health News:Scourge of Obesity 2
(Date:4/17/2015)... DALLAS , April 17, 2015 ... report 2015 Market Research Report on Global and ... This is a professional and the deep ... the report introduces Lysine basic information including definition, ... overview (such as US, Europe ...
(Date:4/17/2015)... R.I , April 17, 2015 CVS ... a conference call on Friday, May 1, 2015, at ... its first quarter financial results. An audio ... through the Investor Relations portion of the CVS Health ... visit http://investors.cvshealth.com . This webcast will be archived ...
(Date:4/17/2015)... SAN DIEGO , April 17, 2015 /PRNewswire/ ... molecular diagnostics, announced today that clinical data presented ... demonstrate that its urine-based Precision Cancer Monitoring ℠ ... detection and monitoring of EGFR T790M ... titled Detection of EGFR T790M Mutation in ...
Breaking Medicine Technology:Lysine Market International (US, Europe, Japan) Research Analysis 2Lysine Market International (US, Europe, Japan) Research Analysis 3Lysine Market International (US, Europe, Japan) Research Analysis 4Lysine Market International (US, Europe, Japan) Research Analysis 5Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 2Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 3Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 4
... The ALS Therapy Development Institute (ALS ... with Neurotune to investigate a potential treatment ... (Photo: http://photos.prnewswire.com/prnh/20120514/DC05793 ) ... health of motor neurons and their connections to muscles ...
... 2012  NxStage® Medical, Inc. (Nasdaq: NXTM ... today announced that former NxStage® System One™ patient ... transplant following four successful years of more frequent ... (Logo: http://photos.prnewswire.com/prnh/20110503/MM94799LOGO ) The ...
Cached Medicine Technology:The ALS Therapy Development Institute Partners with Neurotune to Investigate Potential Treatments for Motor Neuron Disease 2The ALS Therapy Development Institute Partners with Neurotune to Investigate Potential Treatments for Motor Neuron Disease 3Former NxStage Patient Nikolas Gieske Celebrates Kidney Transplant 2Former NxStage Patient Nikolas Gieske Celebrates Kidney Transplant 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: