Navigation Links
Novel therapeutic agent for Tamiflu-resistant pH1N1 influenza virus discovered
Date:4/24/2014

In 2009 the influenza pH1N1 virus caused the first flu pandemic in the 21st century. The virus reached Finland in May 2009 and killed more than 50 people in the country. Since 2011 the pH1N1 virus infects Finns mainly during flu epidemics (winter/spring seasons).

Infections with influenza pH1N1 virus vary from asymptomatic to serious complicated illnesses. World Health Organization has recommended Tamiflu for treatment of patients with severe or progressive illness. The disadvantage of this drug is that it targets viral proteins which mutate quickly and the virus develops resistance to it.

The Medical Systems Virology group at FIMM, together with collaborators has recently sequenced genomes of 135 pH1N1 influenza strains isolated from Finnish patients in 2009-2013 and found one Tamiflu-resistant strain from the 2012-2013 epidemic season. The study was published in the Genome Announcements journal and is now available online.

This finding suggests that there could be more resistant strains in upcoming seasons. Therefore, there is a need for the development of new antiviral agents against pH1N1, says Dr. Triin Lakspere.

In another study published this week the group investigated influenza pH1N1 virus-host cell interaction in detail and found that certain host function could be temporally inhibited with small molecule MK2206 to block influenza infection in cell culture.

Importantly, the virus was unable to acquire resistance to host-directed MK2206 in contrast to virus-directed Tamiflu. This small molecule is in clinical trials against cancer and has high specificity and good pharmacological properties, which could warrant its further development as antiviral drug for treatment of pH1N1 virus infection, Dr. Oxana Denisova says.


'/>"/>
Contact: Denis Kainov
denis.kainov@fimm.fi
358-504-152-35460
University of Helsinki
Source:Eurekalert

Page: 1

Related medicine news :

1. Novel compound halts cocaine addiction and relapse behaviors
2. Penn Medicine researchers uncover hints of a novel mechanism behind general anesthetic action
3. Scientists discover a number of novel genetic defects which cause oesophageal cancer
4. Novel study into breast cancer origins paves way for personalized treatment
5. Novel marker and possible therapeutic target for cardiovascular calcification identified
6. Novel vaccine trial design aims to answer key TB questions
7. Novel cancer vaccine holds promise against ovarian cancer, mesothelioma
8. A novel treatment may reduce myocardial infarction size
9. A new target for cancer and diabetes: A novel role for the adaptor protein p66shc in regulating glucose metabolism
10. Novel compound keeps Parkinsons symptoms at bay in mice
11. New company to develop novel gene therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... Colorado (PRWEB) , ... February 11, 2016 , ... Colorado ... Review as one of 334 spine surgeons to know in 2016 . The ... in the field of spine surgery. , Dr. Corenman understands the importance of ...
(Date:2/11/2016)... ... February 11, 2016 , ... The annual list showcases the 20 Most Promising ... team dedication and commitment to the SharePoint ecosystem. A panel of experts and ... goal is to recognize and promote technology entrepreneurship. , The survey was made ...
(Date:2/11/2016)... ... February 11, 2016 , ... Husted Kicking ... San Diego, CA, on February 6th & 7th, 2016 according to kicking coach Michael ... were not invited to the NFL’s combine in Indianapolis,” says Husted. “The NFL uses ...
(Date:2/10/2016)... ... , ... President Obama’s budget proposal yesterday enables the HHS ... via telehealth, estimated to generate more than $160 million in savings over 10 ... Although there is more to be done, this represents an important victory ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... , a full-service health care communications company offering education, research and medical ... for practitioners and specialists working in infectious diseases. , As the all-inclusive ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... NEW YORK , Feb. 11, 2016 /PRNewswire/ ... a foot-focused suite of products designed to support ... ExoSOLS™, are custom orthotic insoles that combine years ... 1,000 partners in the podiatric field with cutting ... align, and propel . It is supported by ...
(Date:2/10/2016)... DUBLIN , February 11, 2016 /PRNewswire/ ... the addition of the "Molecular Diagnostics ... --> http://www.researchandmarkets.com/research/rp4pg8/molecular ) has announced ... Reports Bundle" report to their offering. ... http://www.researchandmarkets.com/research/rp4pg8/molecular ) has announced the addition of ...
(Date:2/10/2016)... och PITTSBURGH , ... lämnas inte, och detta pressmeddelande får inte ... eller till, och inga anmälningssedlar kommer att ... i, något land där Erbjudandet, distribution av ... Erbjudandet skulle strida mot tillämpliga lagar eller ...
Breaking Medicine Technology: