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Novel target for existing drug may improve success of radiation therapy
Date:9/16/2010

nt for arthritis. The drug had advanced to Phase 2 testing before being discontinued as a potential arthritis treatment.

Reaching Phase 2 testing, however, suggests that a compound has been proven safe, regardless of whether or not it meets performance standards for the specific medical condition for which it was made. These drugs are typically then tested for other uses.

Hallahan learned of the Pfizer compound from an innovative collaboration between Pfizer and Washington University that allows Washington University scientists to view extensive research data on a large array of Pfizer pharmaceutical candidates that are or were in clinical testing.

Don Frail, PhD, chief scientific officer of Pfizer's Indication's Discovery Unit, says the majority of drug candidates tested in development do not give the desired result.

"Yet those drugs that do succeed typically have multiple uses," Frail says. "Hallahan's research has led to an entirely new potential use for one of these compounds in an area of high patient need that otherwise might have been overlooked. This is exactly what our partnership with Washington University is about and is among the first to be funded through the new relationship."

Hallahan is currently partnering with Craig Wegner, PhD, in the Indications Discovery Unit of Pfizer to further understand the pathways impacted by cPLA2 and to evaluate the drug that inhibits its action.


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Contact: Joni Westerhouse
westerhousej@wustl.edu
314-286-0120
Washington University in St. Louis
Source:Eurekalert

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