Navigation Links
Novel target for existing drug may improve success of radiation therapy
Date:9/16/2010

inutes and it contributes to tumor survival."

The cPLA2 enzyme is known to regulate the levels of at last three molecules that promote tumor angiogenesis (the creation of new blood vessel networks to feed cancer cells).

The researchers set out to learn if they could enhance the effect of radiation therapy for lung and brain cancers by inhibiting this enzyme.

The idea was to implant tumors into normal mice and into mice that had been genetically engineered to be unable to produce cPLA2 and then compare the effect of radiation therapy on tumor progression in each.

The immense power of cPLA2 became apparent to Hallahan when a graduate student complained that her experiment failed because she could not grow tumors in mice that lacked the gene that produces cPLA2.

"While implanted tumors progressed as expected in normal mice used in the experiment, they were virtually undetectable in cPLA2 deficient mice," Hallahan says. "The 'failed experiment' was actually a significant discovery of the enormous control cPLA2 has in regulating tumor angiogenesis."

The scientists then examined the blood vessels of the cPLA2 deficient mice. While the blood vessels of cPLA2 deficient mice appeared normal, close inspection revealed the absence of a certain type of contractile cell that regulates blood flow.

"Without these cells, blood vessels can still grow into the tumor but blood cannot flow to the tumor," Hallahan says. "Cancer cannot survive without blood flow to feed it."

The central role of cPLA2 in determining the presence or absence of these contractile cells makes it a prime target for interventional therapy.

"Drugs that target cPLA2 have enormous potential for improving the success of radiation against highly angiogenic tumors," Hallahan says.

Hallahan has already identified an existing drug that inhibits cPLA2. It is a compound originally developed by Wyeth, now part of Pfizer, as a treatme
'/>"/>

Contact: Joni Westerhouse
westerhousej@wustl.edu
314-286-0120
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Novel nanotechnology collaboration leads to breakthrough in cancer research
2. Novel autoantibodies identified in patients with necrotizing myopathy
3. Novel role: EZH2 boosts creation of ovarian cancer blood vessels
4. FSU study takes novel approach to understanding pituitary function
5. OU researcher developing novel therapy for Alzheimers disease
6. Vitamin B3 as a novel approach to treat fungal infections
7. Announcing: Intrinsic Imaging : Radiology Experts Launch Novel Medical Imaging CRO for Clinical Trials
8. Novel approaches to R&D in Africa needed
9. Novel radiotracer shines new light on the brains of Alzheimers disease patients
10. Team led by LA BioMed scientist develops novel approach to study neurological disorders
11. Novel paclitaxel formulation encouraging for treating advanced lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... ... July 01, 2015 , ... Renowned rhinoplasty surgeon and ... 2016 Dallas Rhinoplasty Symposium . Set for March 6th - 8th, the 2016 ... participants from the basic training and fundamentals of nasal surgery through the most modern ...
(Date:7/1/2015)... ... ... Did you know that infertility in men is more common than couples ... Center of Texas (AFCT) would like to talk about some natural ways to increase ... be a “woman’s issue,” male fertility factors can play a role in about 40% ...
(Date:7/1/2015)... ... 01, 2015 , ... Convoy of Hope will partner with local ... on Saturday, August 1, at Spring Lake Park High School. , During the celebration, ... million worth of goods and services including free food, health services, family portraits, job ...
(Date:7/1/2015)... ... 2015 , ... Scoliosis is a disorder in which the normally straight vertical line of the ... 3 percent of the population, or an estimated 6 to 9 million people. While it ... ages of 10 and 15. Most types of scoliosis are more common in girls than ...
(Date:7/1/2015)... ... July 01, 2015 , ... A Priority ... published a top ten list they hope will guide future mesothelioma research. Surviving ... read it now. , More than 450 mesothelioma patients, caregivers, and ...
Breaking Medicine News(10 mins):Health News:Dr. Rod J. Rohrich Announces Dates for 2016 Dallas Rhinoplasty Symposium 2Health News:Dr. Rod J. Rohrich Announces Dates for 2016 Dallas Rhinoplasty Symposium 3Health News:Male Fertility: Improve Testosterone and Fertility With Natural Approaches 2Health News:Male Fertility: Improve Testosterone and Fertility With Natural Approaches 3Health News:Male Fertility: Improve Testosterone and Fertility With Natural Approaches 4Health News:Convoy of Hope Hosts Community Event in the Twin Cities 2Health News:Scoliosis: A Guide for Parents from Orthopedic Surgeon Dr. Fabien Bitan 2Health News:Scoliosis: A Guide for Parents from Orthopedic Surgeon Dr. Fabien Bitan 3Health News:Scoliosis: A Guide for Parents from Orthopedic Surgeon Dr. Fabien Bitan 4Health News:New Report Identifies Top 10 Mesothelioma Research Priorities, According to Surviving Mesothelioma 2
... A new examination of the origin of syphilis supports the ... aboard Christopher Columbus, ships as they sailed home from ... through sexual contact at the time, but adapted to survive ... "Syphilis has been around for 500 years," study co-leader ...
... the tsunami that devastated Japan in March could reach the ... by NOAA scientists. However, they warn there is still a ... where it,s located, where it will go, and when it ... situation on their hands: How do you deal with debris ...
... , WEDNESDAY, Dec. 28 (HealthDay News) -- Regular ... high levels of gluten and could cause problems for people ... made using barely, which contains a form of gluten called ... eliminates gluten or reduces it to very low levels, according ...
... target a single class of proteins and now scientists ... workings of those proteins critical to our health. A ... new results from a team led by Gregory Tall, Ph.D., ... Rochester Medical Center. The work was published recently in ...
... Reporter , TUESDAY, Dec. 27 (HealthDay News) -- Vegan diets ... of eating that exists on the radical fringes of vegetarianism. ... vegan diets a second look, and nutritionists now believe that ... way to live for most people. "Properly planned vegan ...
... Atherosclerosis is a disease of the major arterial blood vessels. ... and stroke. The proinflammatory molecule IL-1 has been linked to ... an antibody specific for IL-1-beta is being studied for its ... attack and stroke). However, a team of researchers led ...
Cached Medicine News:Health News:Columbus Voyage Tied to Syphilis Spread? 2Health News:Debris scatters in the Pacific Ocean, possibly heading to US 2Health News:Debris scatters in the Pacific Ocean, possibly heading to US 3Health News:Scientists fixate on Ric-8 to understand trafficking of popular drug receptor targets 2Health News:The Mainstreaming of Vegan Diets 2Health News:The Mainstreaming of Vegan Diets 3Health News:The Mainstreaming of Vegan Diets 4
(Date:7/1/2015)... N.J. , July 1, 2015  Celsion Corporation ... today announced that Michael H. Tardugno , Chairman, ... Cantor Fitzgerald,s Inaugural Healthcare Conference on Wednesday, July 8, ... held at Le Parker Meridien Hotel located at 119 ... 10019. A copy of the presentation ...
(Date:7/1/2015)... , July 1, 2015 ... study Stationary Oxygen Concentrators Market Shares, Strategy, ... poised to achieve continuing growth as the aging population ... and other respiratory conditions where oxygen is able to ... manner. Portable devices have become affordable and support a ...
(Date:7/1/2015)... , July 1, 2015 New exchange plan ... of 2015 compared to the same time a year ... Scripts (NASDAQ: ESRX ) Exchange Pulse™ report, released ... of 2014, the number of new exchange plan enrollees ... percent in the first quarter of 2015. However, when ...
Breaking Medicine Technology:Celsion Corporation to Present at Cantor Fitzgerald's Inaugural Healthcare Conference on July 8, 2015 2Stationary Oxygen Concentrators Market to Reach $2 Billion by 2021: Radiant Insights, Inc. 2Stationary Oxygen Concentrators Market to Reach $2 Billion by 2021: Radiant Insights, Inc. 3Stationary Oxygen Concentrators Market to Reach $2 Billion by 2021: Radiant Insights, Inc. 4Express Scripts Provides First Look at 2015 Public Exchange Pharmacy Trends 2Express Scripts Provides First Look at 2015 Public Exchange Pharmacy Trends 3Express Scripts Provides First Look at 2015 Public Exchange Pharmacy Trends 4Express Scripts Provides First Look at 2015 Public Exchange Pharmacy Trends 5
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: