Navigation Links
Novel strategy stymies SARS et al.
Date:10/28/2011

ally at the virus itself," explains Professor Christian Drosten, Director of the Institute of Virology at Bonn University Hospital. "And since viral pathogens are highly diverse, each of these agents can attack only certain viruses." Moreover, viruses are also highly mutable, making the weaponry they can deploy against us even more powerful. What works against one viral strain may be essentially useless against another.

The SARS virus, a previously unknown pathogen which threatened to cause a worldwide pandemic in 2003, has spurred on the search for new antiviral substances. Only recently, it was shown that not only Chinese, but also European, bats carry the SARS virus. "But in contrast to the situation with bird influenza, one cannot simply kill these free-living animals in order to eradicate the pathogen," says Drosten. "That would have catastrophic ecological consequences and, apart from that, bats are retiring and secretive in their habits." If one wishes to develop drugs against viruses that can "hide" in animal species, one must explore other alternatives.

The research teams assembled by von Brunn and Drosten have now discovered a way to prevent the replication of a whole family of viruses by depriving them of an essential host factor. They first identified host proteins with which SARS viral proteins interact. This strategy led to the finding that a cellular signaling pathway is essential for the replication not only of the SARS virus, but also of a whole set of related viruses that are pathogenic to humans and animals.

"This signal pathway is normally involved in regulating the immune system," says Drosten. "We used a substance that inhibits the function of one of the proteins in the pathway, and found that it suppresses viral replication." In other words, drugs that block this pathway inhibit the replication of many different viruses, and therefore act as broad-spectrum antivirals. This opens a route to the treatment of conditi
'/>"/>

Contact: Dr. Kathrin Bilgeri
kathrin.bilgeri@lmu.de
49-218-06938
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Novel therapeutic target identified to decrease triglycerides and increase good cholesterol
2. Innovation at Regenstrief: Leveraging novel ideas to improve health care
3. Novel technique reveals both gene number and protein expression simultaneously
4. Novel research set to pinpoint risk of heart attacks and strokes
5. Novel cytokine protects mice from colitis
6. FDA Approves Novel Melanoma Drug
7. St. Michaels North America first to use novel blood-cleaning procedure for kidney transplant
8. Novel DNA sequencer for MDCs systems biology
9. Novel Virus Jumped From Monkeys to Humans, Researchers Find
10. Novel combined therapy extends life, diminishes pain in brain cancer patients
11. Experiment aboard shuttle Atlantis will test novel therapy to build bone during space travel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2015)... The fertility team at Ada IVF ... questions to give intended parents across the globe a ... , After unveiling the most affordable, non-sharing ... clinic has witnessed an increase in fertility patients. Led ... attentive reproductive care — with all-inclusive IVF treatment options ...
(Date:3/30/2015)... (PRWEB) March 30, 2015 “ iCareTech ” ... Report, which takes a look at the latest and coolest ... NewsWatch special reporter and technology expert, conducted the review and ... band that’s dedicated to the medical and health fields. , ... of conversation over the past couple of years. Well, at ...
(Date:3/30/2015)... 2015 Healthy, radiant skin can be ... staff of pharmacists is specially trained and skilled in ... eczema and other conditions. , Most people are unaware ... and/or PCP to tackle most skin conditions and offer ... employed specialty-trained pharmacists who have experience in consulting with ...
(Date:3/30/2015)... A key protein previously implicated in ... important role in the response to viral infection, according ... School of Medicine at Mount Sinai published today in ... associated with inflammation, part of the body’s response to ... in to attack invaders like bacteria and viruses, and ...
(Date:3/30/2015)... In a recent report published by ... is championing effective drug and alcohol treatment for victims ... recover funds to stabilize the addiction treatment programs, and ... drug and alcohol addiction. Harbor Village Detox is extending ... use disorders in New Jersey, in hopes to help ...
Breaking Medicine News(10 mins):Health News:Top Fertility Clinic in Cyprus Answers Key Questions on Egg Donation Process 2Health News:Top Fertility Clinic in Cyprus Answers Key Questions on Egg Donation Process 3Health News:Top Fertility Clinic in Cyprus Answers Key Questions on Egg Donation Process 4Health News:World’s First Medical Intelligent Band was Featured on NewsWatch Television on January 30, 2015 2Health News:MedX Pharmacy Offers Skin Care Tips 2Health News:Mount Sinai Scientists Establish Link Between Neurodegenerative Disease and the Body’s Response to Viral Infection 2Health News:Mount Sinai Scientists Establish Link Between Neurodegenerative Disease and the Body’s Response to Viral Infection 3Health News:Harbor Village Detox Extends Addiction Treatment to NJ & Suggests 7 Ways to Find the Best Recovery Center 2Health News:Harbor Village Detox Extends Addiction Treatment to NJ & Suggests 7 Ways to Find the Best Recovery Center 3
... in Desso ... Turf, BRUSSELS, Belgium, ... in a few synthetic turf,fields. The fields in question are not manufactured by ... assured that,their pitch doesn,t contain any lead., All Desso synthetic turf products ...
... Eating out is common while traveling, but it,s important to ... Memorial Day marks the start of the summer holiday season, ... take a vacation from your diet, cautions Elizabeth Schaub, a ... , Dining out is common when people are on holidays, ...
... tool for mopping up the clumps of mutant protein ... engineered a virus to make an intracellular antibody or ... the brain cells of people with Huntington,s. , Injecting ... mutant huntingtin improves their ability to move their limbs, ...
... in 2007but the price of phosphate fertilizers then doubled ... months from February through April 2008. The effects on ... in Sichuan Province, Chinaa major production area for nitrogen ... had already imposed dramatic new export duties on fertilizer, ...
... and a mathematician may seem like an unlikely duo, but ... and kept millions of sailors from getting lost at sea. ... Rockefeller University, is making history of their own. By using ... have become the first to see, in real time and ...
... sun-related vision damage without proper protection , , SUNDAY, May ... you,re thinking about ultraviolet (UV) protection as the weather ... the sun,s UV rays has been linked to a ... photokeratitis and corneal degenerative changes, according to the American ...
Cached Medicine News:Health News:It's Safe to Play on Desso Synthetic Turf 2Health News:It's Safe to Play on Desso Synthetic Turf 3Health News:Don't Leave Diet Out to Lunch on Vacation 2Health News:'Intrabody' can mop up mutant protein in Huntington's disease model 2Health News:World fertilizer prices continue to soar, scientists stress need for fertilizer efficiency 2Health News:World fertilizer prices continue to soar, scientists stress need for fertilizer efficiency 3Health News:Scientists image a single HIV particle being born 2Health News:Scientists image a single HIV particle being born 3Health News:Just Like Skin, Eyes Can 'Burn' in Strong Sun 2
(Date:3/30/2015)...  Building on the momentum of the first quarter of ... alert systems, has announced aggressive plans to expand its Medicaid ... Care business models. The first quarter addition of ... Tennessee and Louisiana is ... span statewide coverage in each state. This brings the total ...
(Date:3/30/2015)... 26, 2015 Research and Markets ... addition of the "Urological Catheters - ... their offering. This report analyzes ... Thousand Units and US$ Thousands by the ... & Peritoneal Catheters), and Urinary Catheters (Foley ...
(Date:3/30/2015)... , March 30, 2015  Rigrodsky & Long, P.A.: ... Inc. (NASDAQ GM: ASPX )? , Did you ... , Do you think the proposed buyout price is ... rights? Rigrodsky & Long, P.A. ... board of directors of Auspex Pharmaceuticals, Inc. ("Auspex" or the ...
Breaking Medicine Technology:MedScope's Aggressive 2015 Expansion Focuses on Medicaid Waiver and Managed Care Organizations 2Urological Catheters - Global Strategic Business Report 2015-2020: Burgeoning Ageing Populace to Propel Catheter Usage 2Urological Catheters - Global Strategic Business Report 2015-2020: Burgeoning Ageing Populace to Propel Catheter Usage 3Urological Catheters - Global Strategic Business Report 2015-2020: Burgeoning Ageing Populace to Propel Catheter Usage 4Urological Catheters - Global Strategic Business Report 2015-2020: Burgeoning Ageing Populace to Propel Catheter Usage 5Urological Catheters - Global Strategic Business Report 2015-2020: Burgeoning Ageing Populace to Propel Catheter Usage 6Urological Catheters - Global Strategic Business Report 2015-2020: Burgeoning Ageing Populace to Propel Catheter Usage 7AUSPEX PHARMACEUTICALS, INC. SHAREHOLDER ALERT: Rigrodsky & Long, P.A. Announces Investigation Of Buyout 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: