Navigation Links
Novel small molecules used to visualize prostate cancer
Date:3/5/2013

Two novel radiolabeled small molecules targeting prostate-specific membrane antigen (PSMA) have excellent potential for further development as diagnostic and therapeutic radiopharmaceuticals, according to research published this month in The Journal of Nuclear Medicine. The imaging agents123I-MIP-1072 and 123I-MIP-1095were shown to have a high sensitivity of lesion detection in bone, soft tissue and the prostate gland with minimal retention in non-target tissue.

An estimated 238,500 men will be diagnosed with prostate cancer in 2013, and 29,700 will die from the disease. Accurate diagnosis and staging of prostate cancer is critical to determining appropriate patient management. Patients with localized disease may benefit from a curative treatment, while those with bone metastases are typically treated with systemic therapy.

"Current imaging techniques have limitations in diagnosing and staging prostate cancer. New imaging approaches, including the radiolabeled small molecules 123I-MIP-1072 and 123I-MIP-1095, may assess disease status more accurately," said John J. Babich, PhD, lead author of the article "First-in-Man Evaluation of Two High-Affinity PSMA-Avid Small Molecules for Imaging Prostate Cancer." Babich continued, "Improved imaging approaches could better facilitate the selection of optimal treatment and improve patient outcomes."

Separate studies were conducted as part of phase 1 trials under an investigational new drug application to measure the potential effectiveness of the small molecules in diagnosing and staging prostate cancer. In the first study, seven patients with documented prostate cancer were administered doses of 123I-MIP-1072 and 123I-MIP-1095 two weeks apart. In the second study, six healthy volunteers received 123I-MIP-1072 only. Whole body planar imaging and single photon emission computed tomography (SPECT)/computed tomography (CT) were performed for each group, and pharmacokinetics, tissue distribu
'/>"/>

Contact: Susan Martonik
smartonik@snmmi.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment
2. Rutgers team discovers novel approach to stimulate immune cells
3. Novel drug candidates offer new route to controlling inflammation
4. Researchers present new findings for novel pancreatic cancer vaccine
5. Novel biomarkers reveal evidence of radiation exposure
6. VCU Massey Cancer Center sees potential in novel leukemia treatment
7. Study supports urate protection against Parkinsons disease, hints at novel mechanism
8. Novel Natural Sciences Repository Opens Web Portal
9. Novel Anti-Inflammatories May Offer a New Approach for the Treatment of Stroke
10. LA BioMed investigators, Drs. Kevin Bruhn and Noah Craft, develop novel treatment for melanoma
11. Novel radiation therapy safely treats prostate cancer and lowers the risk of recurrence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... In today’s world, a good night’s sleep has become especially ... (a medical problem where the airway collapses during sleep and ... rest they need to face their daily challenges. , ... people in the United States alone have sleep apnea. Of ... those treated, many cannot tolerate their prescribed medical device known ...
(Date:8/30/2014)... One of the most recent dietary trends ... diet. Originally meant for sufferers of gluten intolerance and celiac ... who are looking to get healthier by simply consuming foods ... kind of information erroneous, it also exposes those same consumers ... a drastic change in their food consumption habits. ...
(Date:8/30/2014)... The new review published by Daily Gossip ... Karen Brimeyer, who wanted to make her guide accessible to ... is now easy to find in the form of an ... the author of the new method shares all her tips ... writes in its review that the leaky gut syndrome can ...
(Date:8/30/2014)... August 28th, 2014: With the ... society and the toll that takes on the individual ... continuing education for physical therapists addresses this problem. , ... help others, Hands-On Seminars is offering discounts on their ... learning styles are available to fit the individual needs ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 Ms. Meriwether’s striking ... She certainly has an impressive resume to boost. ... USA in 2012. However, she’s also a two time ... student. Nana trained for the 2008 Olympics and played ... USA website, “This six-foot beauty from Potomac, Maryland is a ...
Breaking Medicine News(10 mins):Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:“What is Gluten: Three Things You Need to Know Before Adopting a Gluten-Free Diet” Reveals What Readers Need to Know About the Benefits of a Strict Gluten Diet - Vinamy 2Health News:Leaky Gut Cure Review Reveals Unique Method to Stop Chronic Symptoms 2Health News:Leader in Manual Therapy Continuing Education Makes it Easier for Physical Therapists to Improve Results on Patients 2Health News:NJ Top Dentists Announces Cover Model for the Healthy Living: Top Dentists Issue 2
... , MOUNTAIN VIEW, Calif., Sept. 17 ... of kidney dialysis services and a major sponsor of nephrology ... Foundation,s "Pathway to a Cure" walk event in California,s capital ... 2009 at The Capital Building, 1315 10th Street, Sacramento, CA. ...
... EDGEWATER, Md., Sept. 17 The dialogue ... company sees the issue from a totally different perspective. ... technological readiness to implement healthcare changes. , , ... released "Healthcare: State-of-Readiness for HITECH and EHR (Electronic Health ...
... , , DALLAS, ... families and eyesight, as many schools require eye exams and teachers ... new school year, it,s also a chance for families to kick ... day green habits. With this in mind, today Essilor announced the ...
... - (OTCBB: GVBP.OB) - GENova Biotherapeutics Inc. ("GENova"), ... that disrupt the advance of life-threatening cancers, today ... Beckpharma Ltd. ("Beckpharma") -a pharmaceutical development company also ... are joining forces in their mutual mission to ...
... ... is to manage their own health and fitness. The incredible growth of Max Muscle ... for the safe, natural, and scientifically-backed and proven products that Max Muscle Sports Nutrition has ... ...
... ... Alopecia treatment, the "Invisible" hair system. Produced individually for those with medically caused hair ... touch and can be worn long-term. , ... London, UK (PRWEB) September 17, 2009 -- London-based White Cliffs ...
Cached Medicine News:Health News:Satellite Healthcare Helps Support the Cure for Kidney Disease in Sacramento 2Health News:National Survey Reveals Healthcare Providers' Technological Readiness to Participate in Electronic Health Records Network 2Health News:National Survey Reveals Healthcare Providers' Technological Readiness to Participate in Electronic Health Records Network 3Health News:Back to School Season is Time for New Green Routines 2Health News:Back to School Season is Time for New Green Routines 3Health News:GENova Biotherapeutics secures new cancer drugs targets 2Health News:GENova Biotherapeutics secures new cancer drugs targets 3Health News:Max Muscle Franchising Is Fueled By The Passion Behind The Brand 2Health News:Max Muscle Franchising Is Fueled By The Passion Behind The Brand 3Health News:Advanced Alopecia Treatment developed by London-based Hair Replacement Provider 2Health News:Advanced Alopecia Treatment developed by London-based Hair Replacement Provider 3
(Date:8/29/2014)... August 29, 2014 According ... Market by Extraction type (SFE, Cold Pressed, Organic ... Care, Pharmaceutical, Food Supplements, Fragrance, & Others) - Global ... defines and segments the Amaranth Seed Oil Market ... size in terms of value. The Amaranth Seed ...
(Date:8/29/2014)... Aug. 29, 2014 Research and Markets ... and Development Trend Forecast of Pharmaceutical Equipment Market in ... Research and Development Trend Forecast of Pharmaceutical Equipment ... analyzes China,s pharmaceutical equipment industry ... demand, competition landscape, and business performance of domestic major ...
(Date:8/29/2014)... Corporation , a neurodiagnostics medical device company based in ... Forcht Dagi , MD, DmedSc, MPH, MBA, FACS, FRCSEd  was ... " Teo Forcht Dagi is an experienced leader with ... said Remis Bistras , President and CEO of Vittamed. ... entrepreneurial expertise to our Board." Dr. Dagi is ...
Breaking Medicine Technology:Amaranth Seed Oil Market worth $700.6 Million by 2019 2Amaranth Seed Oil Market worth $700.6 Million by 2019 3Amaranth Seed Oil Market worth $700.6 Million by 2019 4Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2Vittamed Adds Prominent Neurosurgeon and Venture Capitalist T. Forcht Dagi to Board of Directors 2
...  In a move aimed at bolstering current systems for assessing ... created a new method that combines multiple forms of widely ... which rely on detecting evidence of drug safety issues as ... may be able to identify issues years in advance. ...
... Systems, Inc. (NASDAQ: DCTH ) appointed Gregory ... "As a widely respected hepatologist and 2011 ... Gores will contribute a wealth of clinical knowledge on ... Advisory Board," said Eamonn P. Hobbs, CEO & President ...
Cached Medicine Technology:Taking a Predictive Approach to Identifying Adverse Drug Reactions 2Taking a Predictive Approach to Identifying Adverse Drug Reactions 3Delcath Appoints Gregory Gores, M.D. to Medical Advisory Board 2Delcath Appoints Gregory Gores, M.D. to Medical Advisory Board 3Delcath Appoints Gregory Gores, M.D. to Medical Advisory Board 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: