Navigation Links
Novel small molecules used to visualize prostate cancer
Date:3/5/2013

Two novel radiolabeled small molecules targeting prostate-specific membrane antigen (PSMA) have excellent potential for further development as diagnostic and therapeutic radiopharmaceuticals, according to research published this month in The Journal of Nuclear Medicine. The imaging agents123I-MIP-1072 and 123I-MIP-1095were shown to have a high sensitivity of lesion detection in bone, soft tissue and the prostate gland with minimal retention in non-target tissue.

An estimated 238,500 men will be diagnosed with prostate cancer in 2013, and 29,700 will die from the disease. Accurate diagnosis and staging of prostate cancer is critical to determining appropriate patient management. Patients with localized disease may benefit from a curative treatment, while those with bone metastases are typically treated with systemic therapy.

"Current imaging techniques have limitations in diagnosing and staging prostate cancer. New imaging approaches, including the radiolabeled small molecules 123I-MIP-1072 and 123I-MIP-1095, may assess disease status more accurately," said John J. Babich, PhD, lead author of the article "First-in-Man Evaluation of Two High-Affinity PSMA-Avid Small Molecules for Imaging Prostate Cancer." Babich continued, "Improved imaging approaches could better facilitate the selection of optimal treatment and improve patient outcomes."

Separate studies were conducted as part of phase 1 trials under an investigational new drug application to measure the potential effectiveness of the small molecules in diagnosing and staging prostate cancer. In the first study, seven patients with documented prostate cancer were administered doses of 123I-MIP-1072 and 123I-MIP-1095 two weeks apart. In the second study, six healthy volunteers received 123I-MIP-1072 only. Whole body planar imaging and single photon emission computed tomography (SPECT)/computed tomography (CT) were performed for each group, and pharmacokinetics, tissue distribu
'/>"/>

Contact: Susan Martonik
smartonik@snmmi.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment
2. Rutgers team discovers novel approach to stimulate immune cells
3. Novel drug candidates offer new route to controlling inflammation
4. Researchers present new findings for novel pancreatic cancer vaccine
5. Novel biomarkers reveal evidence of radiation exposure
6. VCU Massey Cancer Center sees potential in novel leukemia treatment
7. Study supports urate protection against Parkinsons disease, hints at novel mechanism
8. Novel Natural Sciences Repository Opens Web Portal
9. Novel Anti-Inflammatories May Offer a New Approach for the Treatment of Stroke
10. LA BioMed investigators, Drs. Kevin Bruhn and Noah Craft, develop novel treatment for melanoma
11. Novel radiation therapy safely treats prostate cancer and lowers the risk of recurrence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... May 21, 2013 Parker Waichman LLP, ... of victims injured by defective medical devices, is addressing ... Joint Surgery on May 15, 2013. The study found ... identify complications that occur in patients with metal-on-metal hip ... ( http://www.jbjs.org/article.aspx?articleid=1684770 ) , “We’ve known ...
(Date:5/21/2013)... Beach, CA (PRWEB) May 21, 2013 ... 3rd Annual EB-5 Investment Summit: Dealmakers Conference in ... Dealmakers Conference will focus on exploring alternative finance ... provide the latest market, legal and economic information, ... immigration and legal professionals within the EB-5 industry. ...
(Date:5/21/2013)... 21, 2013 Arizona State University ... want to develop their ideas into solutions, products ... , The university is recruiting participants for AREA48 ... space” that provides early-stage entrepreneurs with opportunities to ... open to anyone, ASU is particularly seeking participation ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 The ... on cable networks and cable channels across the country, ... on its YouTube channel. The producers of the series ... in the shipping industry, the manufacturing industry, health-related companies, ... medical facilities and medical practitioners in all parts of ...
(Date:5/21/2013)... Angeles, CA (PRWEB) May 21, 2013 ... sports organization, and Bodybuilding.com, the largest online retailer of ... you a new reality-based sports show, Warrior Island. ... vote on; YouTube, Facebook & Twitter, with our unique ... Warrior Island maroons these elite fighters on an island ...
Breaking Medicine News(10 mins):Health News:Parker Waichman LLP Comments on New Study Showing that MRI is Useful for Predicting Failure of Metal-on-Metal Hip Implants 2Health News:Parker Waichman LLP Comments on New Study Showing that MRI is Useful for Predicting Failure of Metal-on-Metal Hip Implants 3Health News:Artisan Business Group to Host EB-5 Investment Conference in Long Beach, California 2Health News:ASU Launches Summer Program for Aspiring Entrepreneurs, Innovators and Inventors 2Health News:ASU Launches Summer Program for Aspiring Entrepreneurs, Innovators and Inventors 3Health News:ASU Launches Summer Program for Aspiring Entrepreneurs, Innovators and Inventors 4Health News:In View hosted by Larry King Announces New Videos on its YouTube Channel 2Health News:Bodybuilding.com Partners with Global Proving Ground’s New Reality Show Warrior Island 2Health News:Bodybuilding.com Partners with Global Proving Ground’s New Reality Show Warrior Island 3
... - Nearly 75 percent have or want to have a wellness ... percent want taxpayer-funded universal ... health ... one of the nation,s leading employee benefits advisory,organizations, today announced key ...
... Cancer Society highlights that long-term favorable trends have stalled ... cancer death rates in the U.S. The report, Cancer ... points out that drops in smoking appear to have ... or slightly declining since 2000 after increasing for more ...
... Attorneys for the Service,Employees International Union claimed in ... and other acts of intimidation against,officers, directors and ... is nothing more than "free speech.", A ... County,Superior Court Commission Jon Rantzman remains in effect ...
... of being diagnosed with late-stage breast cancer , , MONDAY, April ... regular mammograms reduce the risk of being diagnosed with late-stage ... in this age group have regular screenings, a new study ... the Journal of Clinical Oncology . , Women aged ...
... Endorses Competition in the Durable Medical ... Equipment Marketplace, ... jury verdict for its clients today in a business,litigation case involving ... relationship or expectancy. The case,was MP Medical, Inc. v. Philip Wegman, ...
... Red Cross Partners With 3M Corporation and Roush Fenway ... April 21 The American Red Cross,today announced the ... to,recruit NASCAR fans as blood donors and raise awareness ... in America needs blood., (Photo: http://www.newscom.com/cgi-bin/prnh/20080421/DC20034 ...
Cached Medicine News:Health News:Survey: Employers Have High Confidence They Can Control Health Care Costs With Proper Tools 2Health News:Survey: Employers Have High Confidence They Can Control Health Care Costs With Proper Tools 3Health News:American Cancer Society report details cancer prevention efforts 2Health News:American Cancer Society report details cancer prevention efforts 3Health News:American Cancer Society report details cancer prevention efforts 4Health News:SEIU Claims Right of 'Free Speech' to Stalk, Harass, and Threaten Registered Nurses According to the California Nurses Association 2Health News:Mammograms Still a Good Idea for Elderly Women 2Health News:American Red Cross Launches National Campaign to Connect NASCAR Fans With Blood Donations 2Health News:American Red Cross Launches National Campaign to Connect NASCAR Fans With Blood Donations 3
(Date:5/21/2013)... N.J. , May 21, 2013 /PRNewswire-iReach/ -- The ... in NJ has attracted the greatest number of ... its President, Mark Alexay .  ... plans to attend this year.  The show,s still 4 ... different companies.  This is a big surprise and ...
(Date:5/21/2013)... BURLINGTON, Mass. , May 21, 2013 ... leading research and advisory firms for pharmaceutical ... of an emerging agent on key efficacy ... disease progression, has the most influence over ... for advanced/metastatic hormone-receptor (HR-) positive, HER2-negative breast ...
(Date:5/21/2013)... 2013  IsoRay, Inc. (AMEX: ISR ), ... into an exclusive international distribution agreement with IASIS Medical ... Greece . IsoRay is a medical ... radioisotope applications for brain cancer, lung cancer, head and ... IASIS Medical is ideally suited to support ...
Breaking Medicine Technology:Emerging Pharma at ChemOutsourcing 2013 in Record Numbers for Upcoming September Show 2Thought-Leader Opinion and Clinical Data Indicate that Emerging Agents from Two Drug Classes Have Efficacy Advantages Over Currently Used Therapies for HR-Positive, HER2-Negative Breast Cancer 2IsoRay Announces A New International Distributor For Greece 2IsoRay Announces A New International Distributor For Greece 3
Ocuvite® Lutein is an advanced antioxidant supplement formulated to provide nutritional support for the eye....
Expert QC data management solution...
The AVOXimeter 1000E measures:, Oxygen saturation (for diagnosing shunts) , Oxygen content (for Fick Principle calculations), Total hemoglobin concentration , ,Ideal for adult and pediatri...
Inquire...
Medicine Products: