Navigation Links
Novel research set to pinpoint risk of heart attacks and strokes
Date:9/21/2011

A simple blood test is all it could take to tell if you are going to have a heart attack or stroke. A team of international scientists have discovered more than 10 types of unique proteins which are commonly present in the blood of a person who recently suffered a stroke or heart attack.

The breakthrough is a result of an international collaboration led by Nanyang Technological University (NTU)'s lead scientist, Assistant Professor Newman Sze, and the Interuniversity Cardiology Institute of the Netherlands (ICIN)'s lead cardiology scientist, Professor Dominique de Kleijn, who have been working together for more than five years. Lead clinicians Professor Lee Chuen Neng and Dr. Vitaly Sorokin of the National University Hospital (NUH) joined the research team in 2010 to provide medical expertise, clinical samples and data.

The team will now expand their research to study the existence of these proteins, also known as bio-markers, in Singapore's multi-racial population.

Their research is expected to result in the development of a sensitive diagnostic tool possibly in the form of a simple blood test - which can detect these bio-markers so as to help pinpoint the risk of heart diseases in a person before it happens. This is because the more such biomarkers are found in the blood, the higher the risk of a heart attack or stroke.

As these biomarkers are newly discovered, specialised instruments are needed for further research. To this end, Agilent Technologies Inc. (NYSE: A), the world's premier measurement company and a technology leader in communications, electronics, life sciences and chemical analysis, will be partnering NTU to provide top-of-the-line equipment to NTU.

The equipment is used to identify and validate more protein biomarkers associated with cardiovascular diseases. Known as the Agilent HPLC-Chip LC/MS Triple Quadrupole system, this equipment works much faster than other existing methods as it can measure all the biomarkers of interest in a sample at once, speeding up the research process from five years down to one year.

As the cutting-edge equipment is able to process multiple samples simultaneously, the team will also be able to validate over 100 biomarkers in one year, as compared to 10 biomarkers over five years using the conventional method.

Assistant Professor Newman Sze, from NTU's School of Biological Sciences, lead researcher of the project, said the local study will take one year and will involve some 2,000 samples collected in Singapore and the Netherlands.

"After discovering that such biomarkers exist, we need to validate them further to ascertain that people with these proteins are really at a risk of heart attack and stroke. This approach is expected to lead to the development of new and improved tools for early diagnosis of heart attack and stroke patients, way before the diseases strike," said Prof. Sze.

Dr. Vitaly Sorokin, part of the team at the NUH involved in this research, said that Singapore is a good place to validate these biomarkers, as this is a unique opportunity to involve and compare results among the multi-racial population.

"This biomarkers which allows prediction of major cardiovascular events, carries great benefits for the doctors, and will likely lead to the development of prevention strategies or algorithm which will give us a chance to stop heart complications from happening or to improve the clinical outcome of treatment," said Dr. Sorokin, a Russian.

"Having the opportunity to screen and diagnose condition like myocardial infarction and stroke, will give doctors time to prevent the complication of atherosclerosis the hardening of arteries which causes heart attacks and strokes. With such a technology, patients with known conditions like ischemic heart disease and cerebro-vascular disease can be monitored more effectively."

Coronary heart disease and stroke are major worldwide health problems. In Singapore, it accounts for more than 30 per cent of all deaths, with about 15 people dying daily because of heart attack and stroke. This research innovation is the latest in a series of healthcare breakthroughs by NTU. Future Healthcare is one of NTU's Five Peaks of Excellence which the university aims to make its mark globally under NTU 2015 five year strategic plan. The other four peaks include sustainability, new media, the best of the East and West, and innovation.


'/>"/>
Contact: Lester Kok
lesterkok@ntu.edu.sg
65-679-06804
Nanyang Technological University
Source:Eurekalert

Related medicine news :

1. Novel cytokine protects mice from colitis
2. FDA Approves Novel Melanoma Drug
3. St. Michaels North America first to use novel blood-cleaning procedure for kidney transplant
4. Novel DNA sequencer for MDCs systems biology
5. Novel Virus Jumped From Monkeys to Humans, Researchers Find
6. Novel combined therapy extends life, diminishes pain in brain cancer patients
7. Experiment aboard shuttle Atlantis will test novel therapy to build bone during space travel
8. Study uncovers novel genetic variation linked to increased risk of sudden cardiac arrest
9. Novel analysis method organizes genomic cancer data
10. Scientists identify a novel mechanism for evolution of highly aggressive cancers
11. CSHL structural biologists reveal novel drug binding site in NMDA receptor subunit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & ... (TGIG), has initiated cultivation and processing operations at its production facility, and opened ... , Puradigm is the manufacturer of a complete system of proactive air and ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) sponsors ... on June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, ... to helping service members that have been wounded in battle and their families. Venture ...
(Date:6/24/2016)... ... June 24, 2016 , ... Finally, a bruise cream that ... dermaka cream can be incorporated into the post-surgical treatment plans of a variety of ... , dermaka cream is very effective for bruising and causes a rapid resolution of ...
(Date:6/24/2016)... New York (PRWEB) , ... June 24, 2016 , ... ... marijuana patients optimize the ingestion of their medication by matching users with high quality ... users to compare pieces with no commitment. , Inhale was founded by two brothers, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on the ... announced that patient enrollment in its ongoing randomized ... has exceeded 50% of its 24-patient target. Capricor ... the third quarter of 2016, and to report ...
(Date:6/23/2016)... BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a ... second affiliate in Latin America . ... ... ... ...
(Date:6/23/2016)... , June 23, 2016  Experian ... integrating and transforming the patient payment and ... several innovative new products and services that ... its revenue cycle offerings. These award-winning solutions ... efficient workflows, remain compliant in an ever-changing ...
Breaking Medicine Technology: