Navigation Links
Novel radiotracer shines new light on the brains of Alzheimer's disease patients
Date:6/24/2010

of florbetapir, then received a PET scan of their brains. The brain scans, acquired over a 90-minute period, allowed the researchers to see the uptake of florbetapir in the brain over time.

Florbetapir had significantly heavier accumulation in the Alzheimer's patients' brains compared to the healthy volunteers, collecting in brain regions expected to be high in beta-amyloid deposits based on previous research. The results in AD patients were readily distinguishable from those of healthy subjects by 30 minutes after injection, and the differences continued for up to at least 90 minutes after injection of florbetapir. None of the AD patients or healthy volunteers suffered any ill effects from florbetapir and showed normal vital signs, electrocardiograms and blood-work after the scan.

"We could easily tell apart the two groups of patients. Those without Alzheimer's disease retained much less of the compound, and those with Alzheimer's disease retained much more of it," Wong says. "This is the first time we've been able to get results like this with a compound that can travel beyond the confines of a major academic medical center to the majority of the U.S. population."

Wong adds that florbetapir's portability could lead to numerous applications for this compound. For example, though Alzheimer's disease can usually be diagnosed from neurocognitive tests, imaging with florbetapir could help settle tricky cases in which patients might have other forms of dementia instead. The compound may also be useful in future studies designed to help solve current medical mysteries, such as which patients are most likely to progress from mild cognitive impairment to full-blown Alzheimer's disease.

Florbetapir may also be useful in trials of new experimental Alzheimer's therapeutics to measure their success, a purpose for which this compound is already being used on a limited basis, Wong says.


'/>"/>

Contact: Christen Brownlee
cbrownlee@jhmi.edu
410-955-7832
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Team led by LA BioMed scientist develops novel approach to study neurological disorders
2. Novel paclitaxel formulation encouraging for treating advanced lung cancer
3. Novel Drug Combats Advanced Melanoma
4. Novel RNA interference screening technique identifies possible path for malignant glioma treatment
5. Novel anti-malarial drug candidate found by UT Southwestern researchers
6. ASCO data highlight novel anti-cancer approach that exposes tumors to immune attack
7. Research identifies patterns of CD24, a novel biomarker for non-small cell lung carcinomas
8. Third European Novel Food Approval Received by Tahitian Noni International
9. Novel nanoparticles prevent radiation damage
10. Novel soy germ-based dietary supplement, SE5-OH containing natural S-Equol, examined for safety and influence on hormones in pre- and post-menopausal women
11. Novel Method Eyed for Normalizing Blood Sugar
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... July 11, 2014 New Albany dental expert ... with the idea of paying $20,000 for new teeth. , “The ... worth it for many patients,” Dr. Receveur said. , For those ... love, or have a lifetime of embarrassment over their smile, ... paying for a better, more enjoyable life. , Still, Dr. Receveur ...
(Date:7/10/2014)... (PRWEB) July 11, 2014 Karen Middleton, ... President and CEO of Planned Parenthood of the Rocky ... Senator Mark Udall and Representative Diana DeGette were in ... Court’s Hobby Lobby decision and keeping bosses out of ... representatives listened to the president today in Denver addressing ...
(Date:7/10/2014)... Ticketability.com has a wide array of tickets ... tickets for San Diego are being added to the inventory. ... and the newly added September 28 show is drawing a ... Here to view the selection of discounted seats at ... become available to the general public on July 18 at ...
(Date:7/10/2014)... York City, NY (PRWEB) July 10, 2014 ... the life sciences industry, has launched a new website. ... responsiveness, as well as increased access to the firm’s ... new cbpartners.com provides an ideal platform to showcase our ... health access issues,” says CBPartners’ Chief Executive Officer, Cyrus ...
(Date:7/10/2014)... Ivalua, the global leader in ... 4th “Trending in Procurement” report on the value ... day multinational corporations process thousands of invoices, purchase ... meet this challenge, more and more purchasing departments ... defined as a suite of integrated applications designed ...
Breaking Medicine News(10 mins):Health News:Louisville Dental Expert Offers 5 Tips for Deciding Whether Cost or Value of Dental Implants are More Important 2Health News:Louisville Dental Expert Offers 5 Tips for Deciding Whether Cost or Value of Dental Implants are More Important 3Health News:Louisville Dental Expert Offers 5 Tips for Deciding Whether Cost or Value of Dental Implants are More Important 4Health News:Naral Pro-Choice Colorado & Planned Parenthood Of The Rocky Mountains Statement On Udall & Degette Staying In Dc To Introduce Legislation 2Health News:Paul McCartney Tickets for San Diego: Ticketability.com Announces Discounted Tickets for McCartney’s Tour Stop at Petco Park on September 28 2Health News:CBPartners Announces New Website 2Health News:‘Source-to-Pay’ e-Procurement Is Real Performance Driver for Purchasing Departments 2Health News:‘Source-to-Pay’ e-Procurement Is Real Performance Driver for Purchasing Departments 3
... developed deposits, study finds , , WEDNESDAY, Feb. 4 (HealthDay ... sickened more than 50,000 kids last fall resulted in ... developing kidney problems, according to just-released Beijing research on ... in Taiwan and 10 percent of those who drank ...
... (AUA) will hold its Annual Scientific Meeting in Chicago, ... Meeting is the largest meeting of urologic professionals in ... urologists and healthcare professionals from around the world. This ... more than 300 exhibitors will showcase their products and ...
... Pharmacies will host an in-store Healthy Heart Event., ... well as provide information to help patients better ... Pharmacists will also help patients, ... blood pressure and heart disease., WHY: ...
... /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: ... will be presenting at the National Cancer Institute,s Office ... series. The title of the presentation is "Selective Cytotoxic ... Effects in Patients with Advanced Breast Cancer," and will ...
... provider of complete solutions for the analysis of Next ... Molecular Biology Laboratory (EMBL) installed a Genomatix Mining Station ... Facility. These systems deliver the only complete and integrated ... generated by the sequencer, to a molecular level understanding ...
... is seeking nominations for the Fourth Annual Bioscience Awards ... interested in nominating a company or individual for an ... are: Entrepreneurial, Best New Product or Progress, Leadership in ... submit documentation and narratives that fulfill several criteria and ...
Cached Medicine News:Health News:Tainted China Formula Caused High Rate of Kidney Stones in Kids 2Health News:Tainted China Formula Caused High Rate of Kidney Stones in Kids 3Health News:Bionovo Announces Presentation at the National Cancer Institute 2Health News:Bionovo Announces Presentation at the National Cancer Institute 3Health News:EMBL GeneCore purchases Genomatix's next generation sequencing data analysis solution 2Health News:EMBL GeneCore purchases Genomatix's next generation sequencing data analysis solution 3Health News:GBC Seeks Nominations for Fourth Annual Bioscience Awards 2
(Date:1/15/2014)... 15, 2014 As health officials across the Midwest warn ... pharmacies in Michigan will offer free ... enabling Meijer pharmacists to administer tests and, in some cases, ... physician participating in the study. The ...
(Date:1/15/2014)... , January 15, 2014 Shire plc (LSE: SHP, ... Office of Fair Trading (OFT) approval condition to the announced tender ... VPHM).   As a result of the waiver, the ... to complete the tender offer on January 24, 2014 following the ...
(Date:1/15/2014)... Tegra Medical is very pleased to announce the appointment ... Chief Executive Officer.  Mark was promoted from his current role ... company,s four facilities in Massachusetts , ... Tegra Medical in 2012 with 20+ years of broad-based operations, ...
Breaking Medicine Technology:Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3
... /PRNewswire/ -- Treatment of,coronary artery disease (CAD) appears to ... study published today in The,American Journal of Cardiology. , ... 10.6 percent from 2002 to 2005, possibly due,to broader ... as well as declines in risk factors like smoking. ...
... Research from Non-clinical Studies Presented at the ... Symposia Molecular,Targets for Cancer Meetings Support Phase ... March 20, 2007,/PRNewswire-FirstCall/ -- Sunesis Pharmaceuticals, Inc. ... SNS-314, at,two leading scientific meetings focused on ...
Cached Medicine Technology:Hospitalization Rates for Coronary Artery Disease Decline in the,U.S. 2Hospitalization Rates for Coronary Artery Disease Decline in the,U.S. 3Sunesis Pharmaceuticals Presents SNS-314 Aurora Kinase Inhibitor,Data Showing Broad Anti-Tumor Activity, Dosing Flexibility 2Sunesis Pharmaceuticals Presents SNS-314 Aurora Kinase Inhibitor,Data Showing Broad Anti-Tumor Activity, Dosing Flexibility 3
Series I Small Joint Arthroscopy Hand Instruments feature small yet durable instruments specifically designed for small joint arthroscopy. They are available in a variety of low profile styles: strai...
Series I Small Joint Arthroscopy Hand Instruments feature small yet durable instruments specifically designed for small joint arthroscopy. They are available in a variety of low profile styles: strai...
Series I Small Joint Arthroscopy Hand Instruments feature small yet durable instruments specifically designed for small joint arthroscopy. They are available in a variety of low profile styles: strai...
Series I Small Joint Arthroscopy Hand Instruments feature small yet durable instruments specifically designed for small joint arthroscopy. They are available in a variety of low profile styles: strai...
Medicine Products: