Navigation Links
Novel radiotracer shines new light on the brains of Alzheimer's disease patients
Date:6/24/2010

A trial of a novel radioactive compound readily and safely distinguished the brains of Alzheimer's disease patients from healthy volunteers on brain scans and opens the doors to making such imaging available beyond facilities that can manufacture their own radioactive compounds. The results, reported by a Johns Hopkins team in the June Journal of Nuclear Medicine, could lead to better ways to distinguish Alzheimer's from other types of dementia, track disease progression and develop new therapeutics to fight the memory-ravaging disease.

Previously, the only way to peer into the brains of Alzheimer's patients was through autopsy or the use of another radioactive compound used in scans, or radiotracer, known as Pittsburgh compound or PIB. PIB is drawn to a protein known as beta-amyloid, which accumulates abnormally in the brains of Alzheimer's patients. However, PIB has a half-life of only 20 minutes, meaning that half of the substance degenerates every 20 minutes after it is made. Consequently, PIB's use is possible only at a few hospitals or academic medical centers with facilities to manufacture it since this compound degenerates so rapidly.

To solve this conundrum, Dean F. Wong, M.D., Ph.D., a professor of radiology and psychiatry at the Johns Hopkins University School of Medicine, and his colleagues looked to a new radiotracer known as 18F-AV-45 (also known as florbetapir F18). This compound, based on the radioactive isotope fluorine-18, is drawn to beta-amyloid like PIB. However, unlike PIB, florbetapir has a half-life of about 110 minutes, greatly increasing its ability to be transported significant distances away from manufacturing facilities.

Testing the new compound for the first time in humans, Wong and his colleagues recruited 26 volunteers 11 previously diagnosed with Alzheimer's disease, and 15 healthy subjects of similar age who performed normally on cognitive tests. Each of these volunteers received an injection of florbetapir, then received a PET scan of their brains. The brain scans, acquired over a 90-minute period, allowed the researchers to see the uptake of florbetapir in the brain over time.

Florbetapir had significantly heavier accumulation in the Alzheimer's patients' brains compared to the healthy volunteers, collecting in brain regions expected to be high in beta-amyloid deposits based on previous research. The results in AD patients were readily distinguishable from those of healthy subjects by 30 minutes after injection, and the differences continued for up to at least 90 minutes after injection of florbetapir. None of the AD patients or healthy volunteers suffered any ill effects from florbetapir and showed normal vital signs, electrocardiograms and blood-work after the scan.

"We could easily tell apart the two groups of patients. Those without Alzheimer's disease retained much less of the compound, and those with Alzheimer's disease retained much more of it," Wong says. "This is the first time we've been able to get results like this with a compound that can travel beyond the confines of a major academic medical center to the majority of the U.S. population."

Wong adds that florbetapir's portability could lead to numerous applications for this compound. For example, though Alzheimer's disease can usually be diagnosed from neurocognitive tests, imaging with florbetapir could help settle tricky cases in which patients might have other forms of dementia instead. The compound may also be useful in future studies designed to help solve current medical mysteries, such as which patients are most likely to progress from mild cognitive impairment to full-blown Alzheimer's disease.

Florbetapir may also be useful in trials of new experimental Alzheimer's therapeutics to measure their success, a purpose for which this compound is already being used on a limited basis, Wong says.


'/>"/>

Contact: Christen Brownlee
cbrownlee@jhmi.edu
410-955-7832
Johns Hopkins Medical Institutions
Source:Eurekalert

Related medicine news :

1. Team led by LA BioMed scientist develops novel approach to study neurological disorders
2. Novel paclitaxel formulation encouraging for treating advanced lung cancer
3. Novel Drug Combats Advanced Melanoma
4. Novel RNA interference screening technique identifies possible path for malignant glioma treatment
5. Novel anti-malarial drug candidate found by UT Southwestern researchers
6. ASCO data highlight novel anti-cancer approach that exposes tumors to immune attack
7. Research identifies patterns of CD24, a novel biomarker for non-small cell lung carcinomas
8. Third European Novel Food Approval Received by Tahitian Noni International
9. Novel nanoparticles prevent radiation damage
10. Novel soy germ-based dietary supplement, SE5-OH containing natural S-Equol, examined for safety and influence on hormones in pre- and post-menopausal women
11. Novel Method Eyed for Normalizing Blood Sugar
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda ... orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including ... accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. ...
(Date:6/24/2016)... Rhinebeck, NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of ... of companies that call for a minimum wage raise to $12 an hour by 2020 ... wage. This will restore the lost value of the minimum wage, assure the wage floor ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented its first-ever ... Medicine conference in Ponte Vedra Beach, FL. The awards honor the outstanding work ... Practice and Pediatric Emergency Medicine Practice. , “With this award, we recognize ...
(Date:6/24/2016)... ... 24, 2016 , ... Puradigm® & Innovative Solutions today announced ... and processing operations at its production facility, and opened its first two dispensaries ... manufacturer of a complete system of proactive air and surface purification solutions for ...
(Date:6/24/2016)... ... ... recruitment firm Slone Partners is pleased to announce the placement of Suzanne ... of North American Capital Sales at HTG Molecular . , In ... commercialization of the HTG EdgeSeq system and associated reagents in North America. , Headquartered ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Capricor Therapeutics, ... a biotechnology company focused on the discovery, development ... patient enrollment in its ongoing randomized HOPE-Duchenne clinical ... 50% of its 24-patient target. Capricor expects the ... quarter of 2016, and to report top line ...
(Date:6/23/2016)... , June 23, 2016 Bracket , ... launch its next generation clinical outcomes platform, Bracket eCOA (SM) ... held on June 26 – 30, 2016 in ... first electronic Clinical Outcome Assessment product of its kind to ... #715. Bracket eCOA 6.0 is a flexible platform ...
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
Breaking Medicine Technology: