Navigation Links
Novel prostate cancer vaccine taking aim at cancer cell 'sweet spot'
Date:1/8/2009

Molecules of sugar sitting on the surface of cancer cells are keys to the development of a new vaccine aimed at both treating and stopping the spread of certain types of cancers called carcinomas, which include prostate, breast, ovarian and lung, among others. Armed with a new two-year grant for $600,000 from the Gateway for Cancer Research, an Illinois-based philanthropic foundation, immunologist Alessandra Franco, M.D., Ph.D., and her co-workers at the Moores Cancer Center at the University of California, San Diego are hoping to develop a low-cost immunotherapy for prostate carcinoma that may also have use against a variety of other carcinomas as well.

Franco, adjunct assistant professor of pediatrics at the UC San Diego School of Medicine, and her co-workers have spent the last decade proving that the immune system's destructive, or "killer," T-cells can recognize sugars on tumor cell surfaces. Her laboratory pioneered and developed the notion that conventional T-cells recognize not only peptides, or pieces of proteins, but also sugars, specifically small carbohydrates called tumor-associated carbohydrate antigens (TACA) expressed on carcinoma cell surfaces. Ideally, this recognition enables the T-cell to attach to and kill the cancer cell.

The researchers have designed "glycopeptides," compounds in which sugars are linked to peptides that are recognized by T-cells. When given as part of a vaccine therapy, these glycopeptides rouse immune system T-cells into recognizing TACA on tumor cell surfaces, attacking and killing the cancer cells. Her research team has already shown that both normal mice and mice with tumors that were vaccinated could successfully generate carbohydrate-specific T-cells that could kill tumors expressing the same carbohydrate molecule.

Cancer vaccines have had a mixed record of success at best. Most immunotherapies have focused on revving up immune system antibodies to recognize proteins on tumor cells. '/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
2. Novel virus detection identifies new viruses in study of respiratory infections and asthma attacks
3. Researchers uncover novel mechanism that balances the sizes of functional areas in the brain
4. Novel Cooling Therapy May Have Aided Injured Football Player
5. ECLIPSE data on effects of Otsukas investigational novel treatment, Tolvaptan
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. GrantAdler Shipping Novel Implantable Vascular Access Port
8. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
9. Novel strategy under study for aggressive leukemia
10. ISTO Technologies Receives 510(k) Clearance for a Novel Bone Graft Substitute and Bone Graft Extender
11. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... Mountain Point Medical Center, a campus of Jordan ... Friday, May 29, 2015 at 11 a.m., followed by a ... medical center, set to officially open on June 1, 2015, ... , “The opening of Mountain Point Medical Center is ... community,” said Kent Loosle, CEO of Mountain Point Medical Center. ...
(Date:5/22/2015)... 2015 Combination therapy, or polytherapy, ... chronic obstructive pulmonary disorder (COPD) as the dominant ... plc as well as Germany’s Boehringer Ingelheim compete ... But will market payers, clinicians and patients be ... to completely new ones? , In spite of ...
(Date:5/22/2015)... Coordinating care for people with complex, ... have not been reimbursed or rewarded for care ... has paved the way by offering reimbursement for ... of Oculus Health , an innovative care ... platform will now be able to easily engage ...
(Date:5/22/2015)... 22, 2015 ZH Healthcare ... solutions, announced today that Bill Lane, joins ZH’s ... developer of BlueEHS,a first of its kind, Freemium ... customizable Electronic Health Records (EHR) with an integrated ... telemedicine-enabled comprehensive patient portal, and more. Combined with ...
(Date:5/22/2015)... sweetFrog Enterprises, LLC. is pleased to announce the opening of ... 16th sweetFrog store located in the Lone Star State. The ... Inc. 500 list of fastest growing companies in 2014. ... for 20 years and love the natural beauty and friendly ... Palestine, sweetFrog locations. “We are really excited about giving back ...
Breaking Medicine News(10 mins):Health News:Mountain Point Medical Center, a Campus of Jordan Valley Medical Center, Hosts Ribbon Cutting Ceremony and Community Celebration on Friday, May 29, 2015 2Health News:Chronic Obstructive Pulmonary Disorder Therapeutics Market Discussed in In-demand FirstWord Report Published at MarketPublishers.com 2Health News:Oculus Health Care Coordination Platform Officially Launched 2Health News:Oculus Health Care Coordination Platform Officially Launched 3Health News:Oculus Health Care Coordination Platform Officially Launched 4Health News:ZH Healthcare Adds Bill Lane to Advisory Board 2Health News:sweetFrog Opens New Location in Jacksonville, Texas 2
... Expected to Result in Improved Nursing Productivity in the Treatment ... ... City, Fla. (PRWEB) February 27, 2009 -- iSirona®, an innovative ... that it has signed an agreement with NxStage Medical, Inc. ...
... Chart Links, LLC announces the implementation of its rehabilitation ... rehabilitation centers for Southeast Missouri Hospital, a 269-bed regional ... The implementation includes functionality for electronically managing therapy documentation, ... ...
... Woman,s Measurements , New web-based research has quantified the ... researchers manipulated the features of one woman into 243 ... hip and waist widths. Then more than 34,000 people ... face remained exactly the same in all of the ...
... 26 President Obama,s first proposed budget for ... for health care to an additional 500,000 deserving ... need for continued growth in programs for the ... the resources to deliver quality health care for ...
... PARK, Ill., Feb. 26 Abbott ( NYSE: ABT ... Medical,Optics (AMO). AMO is now a wholly owned subsidiary ... The acquisition of AMO enhances and ... a leadership position in the large and,growing eye care market. ...
... out of the more than 5,000 US hospitals tracked by HIMSS Analytics ... , ... Chicago (Vocus) February 26, 2009 -- As the country moves to ... 42 US hospitals recognized as a Stage 6 by HIMSS Analytics serve ...
Cached Medicine News:Health News:iSirona Signs Reference Selling Agreement with NxStage 2Health News:Southeast Missouri Hospital Implements Chart Links Rehabilitation Software for Therapists 2Health News:Southeast Missouri Hospital Implements Chart Links Rehabilitation Software for Therapists 3Health News:Plastic and reconstructive surgery ... in brief 2Health News:President's 2010 Budget Request Strongly Supports VA Programs 2Health News:Abbott Completes Acquisition of Advanced Medical Optics 2Health News:Honored for EMR Sophistication, HIMSS Analytics Announces Stage 6 Hospitals 2Health News:Honored for EMR Sophistication, HIMSS Analytics Announces Stage 6 Hospitals 3
(Date:5/22/2015)... , May 22, 2015  In a sweeping ... the U.S., T1D Exchange researchers conclude that ... type 1 diabetes across all age groups, but especially ... most up-to-date picture of diabetes treatment, underscoring the need ... and technologies that can help type 1 patients achieve ...
(Date:5/22/2015)... 22, 2015  China Nepstar Chain Drugstore Ltd. (NYSE: ... drugstore chain in China based ... the resignation of Mr. Fuxiang Zhang as ... immediately. Ms. Rebecca Yingnan Zhang has been ... of directors, effective immediately. Meanwhile, Ms. Zhang resigned from ...
(Date:5/21/2015)... DUBLIN , May 21, 2015 ... has announced the addition of the "North ... & Graft), by Application (Surgical Wound, & Ulcer), ... Forecast to 2019" report to their offering. ... wound care market is estimated to grow at ...
Breaking Medicine Technology:Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 2Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 3Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 4Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 5China Nepstar Chain Drugstore Ltd. Announces Management Change and New Director Appointment 2China Nepstar Chain Drugstore Ltd. Announces Management Change and New Director Appointment 3North American Active Wound Care Market 2015-2019 with Smith and Nephew, Molyncke HealthCare & ConvaTec Dominating 2
... Korea, Jan. 3, 2012 /PRNewswire-Asia/ -- The Ministry of Health ... Institute (Ko Kyung-Hwa) announced that a 19-year-old woman, Tan Hui-Linn, ... government,s Medical Korea project and will receive surgery at the ... Tan Hui-Linn,s life that was once full of hopes shattered ...
... (Nasdaq: BMRN ) today announced that Jean-Jacques Bienaime, ... at the J.P. Morgan Healthcare Conference in San Francisco on ... Interested parties may access a live audio webcast of ... website, www.BMRN.com .  A replay of the call will ...
Cached Medicine Technology:Acid Attack Victim from Malaysia Restores Her Lost Face with Support of Medical Korea 2BioMarin to Present at the J.P. Morgan Healthcare Conference 2
Meter Trax Control is a whole blood quality control that can be used for glucose, hemoglobin and hematocrit testing on point of care instruments....
Lyphochek® Hemoglobin A1C Linearity Set is a human whole blood based product designed to verify linearity throughout the patient reportable range of hemoglobin A1C assays....
Liquichek Reticulocyte Control is a human whole blood based control designed to monitor manual and automated methods for counting reticulocytes. Assayed values are provided at three clinically signif...
Seroconversion and Antigen Panel Chart...
Medicine Products: