Navigation Links
Novel mouse model for autism yields clues to a 50-year-old mystery
Date:3/20/2012

Early disruptions in serotonin signaling in the brain may contribute to autism spectrum disorder (ASD), and other "enduring effects on behavior," Vanderbilt University researchers report.

Serotonin is a brain chemical that carries signals across the synapse, or gap between nerve cells. The supply of serotonin is regulated by the serotonin transporter (SERT). In 2005, a team of Vanderbilt researchers led by Randy Blakely and James Sutcliffe identified rare genetic variations in children with ASD that disrupt SERT function.

In a new study published this week in the Proceedings of the National Academy of Sciences (PNAS), the researchers report the creation of a mouse model that expressed the most common of these variations.

The change is a very small one in biochemical terms, yet it appears to cause SERT in the brain to go into "overdrive" and restrict the availability of serotonin at synapses.

"The SERT protein in the brain of our mice appears to exhibit the exaggerated function and lack of regulation we saw using cell models," said Blakely, director of the Vanderbilt Silvio O. Conte Center for Neuroscience Research.

"Remarkably, these mice show changes in social behavior and communication from early life that may parallel aspects of ASD," noted first author Jeremy Veenstra-VanderWeele, assistant professor of Psychiatry, Pediatrics and Pharmacology.

The researchers conclude that a lack of serotonin during development may lead to long-standing changes in the way the brain is "wired."

In 1961, investigators at Yale discovered that as many as 30 percent of children with autism have elevated blood levels of serotonin, a finding described as "hyperserotonemia."

Since then, these findings have been replicated many times. Indeed, hyperserotonemia is the most consistently reported biochemical finding in autism, and is a highly inherited trait. Yet, the cause or significance of this "
'/>"/>

Contact: Bill Snyder
william.snyder@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert  

0

GOOD

Page: 1 2

Related medicine news :

1. Unprecedented academic-industry collaboration seeks new drugs and novel treatments for autism
2. Novel plastics and textiles from waste with the use of microbes
3. UC San Diego among first in nation to treat brain cancer with novel viral vector
4. Students at Western University develop a novel way to teach interdisciplinary care
5. UH Case Medical Center publishes study on novel treatment for skin lymphoma
6. Mass. General researchers find novel way to prevent drug-induced liver injury
7. Rutgers, Massachusetts General investigators find novel way to prevent drug-induced liver injury
8. NIH scientists identify novel approach to view inner workings of viruses
9. Novel Stem Cell Treatment May Hold Promise for Type 1 Diabetes
10. KalVista and JDRF form research partnership for novel treatment of diabetic eye disease
11. Novel brain tumor vaccine acts like bloodhound to locate cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel mouse model for autism yields clues to a 50-year-old mystery
(Date:5/24/2013)... Before you start the grill, before you watch the game, ... and Hoda Kotb on the Today Show on Memorial Day. ... Kathie Lee and Hoda, including the new LawnBott® LB75 robotic mower. ... in the military who made the ultimate sacrifice for us. ... friends and family and enjoy the day. With a LawnBott® ...
(Date:5/24/2013)... Mozes HealthDay Reporter , , FRIDAY, May 24 ... accomplishments are remarkable. But it was a physical challenge ... top of her sport. "I was an 11-year-old ... my scoliosis was diagnosed by my orthopedic surgeon," said ... Scoliosis Research Society and the American Academy of Orthopaedic ...
(Date:5/24/2013)... May 24, 2013 ResortQuest Real Estate® ... the Dayna Feher team at the firm’s Bethany Beach ... Delaware resorts her home in 1975. Her real estate ... in all aspects of the real estate business - ... past 12 years, a licensed sales associate. , ...
(Date:5/24/2013)... Mirena IUD lawyers at the Rottenstein Law Group ... more than 59,229 complaints since 2004 from women claiming they ... known as the Mirena IUD.* , Among the most common ... ‘expulsion,’ where the IUD came out on its own. There ... News article. “Abdominal pain is also common, with 3,774 complaints. ...
(Date:5/24/2013)... 24, 2013 CHI-California Healthcare Institute ... the California congressional delegation, joined by over 40 ... user fees paid to the U.S. Food and ... future across-the-board cuts will not include user fees ... Agriculture, Rural Development and FDA Appropriations Bill. CHI ...
Breaking Medicine News(10 mins):Health News:LawnBott® Visits the Today Show with Kathie Lee and Hoda 2Health News:Top-Ranked Golfer Beats Scoliosis 2Health News:Top-Ranked Golfer Beats Scoliosis 3Health News:Tammy Mushrush Joins ResortQuest Real Estate® and the Dayna Feher Team 2Health News:Sufferers of Alleged Mirena IUD Side Effects Lodge More Than 59,000 Complaints With FDA, Rottenstein Law Group LLP Notes 2Health News:California Biomedical Industry Leaders Urge Congress to Take Action on FDA User Fees for FY2014 2Health News:California Biomedical Industry Leaders Urge Congress to Take Action on FDA User Fees for FY2014 3
... 2009 A new study published in Value ... in the U.S. and recent clinical findings of the ... the history of economic articles published on migraine using ... articles to identify possible health risks associated with migraines ...
... met its match. A tiny molecule, quercetin, found in most plant-based foods douses the flames before damaging lesions ... Click here for more information. , , ... , , , , ... , , , , ...
... SANTA MONICA, Calif., Feb. 2 A national consumer ... lobbying positions on the electronic medical record provisions of ... an independent journalist that Google,s presence on the bill ... public policy team for an immediate answer. The letter ...
... Ga., Feb. 2 Aflac Incorporated today,reported its fourth quarter ... the strengthening of the yen to the dollar,in the fourth ... the fourth quarter of 2007. Net earnings were $197 ... $.78 per share, a year ago. , ...
... Feb. 2 Rochester Medical Corporation (Nasdaq: ROCM ... December 31, 2008.The Company reported sales of $8,436,000 for the ... last year. It also reported net income of $54,000 ... $272,000 or $.02 per diluted share for the first quarter ...
... Calif., Feb. 2 In conjunction with DURECT ... 2008 financial results press release, you are invited ... be broadcast live over the Internet on Monday, ... PST).(Logo: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO )A live audio webcast of ...
Cached Medicine News:Health News:Study reviews health risks, economic burden of migraine 2Health News:Inflammation in colon may get doused before fueling cancer development 2Health News:Inflammation in colon may get doused before fueling cancer development 3Health News:Inflammation in colon may get doused before fueling cancer development 4Health News:Inflammation in colon may get doused before fueling cancer development 5Health News:Consumer Watchdog to Google: Publicly Disclose Your Lobbying Positions on Electronic Medical Record Provisions in Stimulus Bill 2Health News:Aflac Incorporated Announces Fourth Quarter Results, Sees 2008 RBC Ratio Above 450%, Affirms 2009 Operating EPS Target 2Health News:Aflac Incorporated Announces Fourth Quarter Results, Sees 2008 RBC Ratio Above 450%, Affirms 2009 Operating EPS Target 3Health News:Aflac Incorporated Announces Fourth Quarter Results, Sees 2008 RBC Ratio Above 450%, Affirms 2009 Operating EPS Target 4Health News:Aflac Incorporated Announces Fourth Quarter Results, Sees 2008 RBC Ratio Above 450%, Affirms 2009 Operating EPS Target 5Health News:Aflac Incorporated Announces Fourth Quarter Results, Sees 2008 RBC Ratio Above 450%, Affirms 2009 Operating EPS Target 6Health News:Aflac Incorporated Announces Fourth Quarter Results, Sees 2008 RBC Ratio Above 450%, Affirms 2009 Operating EPS Target 7Health News:Aflac Incorporated Announces Fourth Quarter Results, Sees 2008 RBC Ratio Above 450%, Affirms 2009 Operating EPS Target 8Health News:Aflac Incorporated Announces Fourth Quarter Results, Sees 2008 RBC Ratio Above 450%, Affirms 2009 Operating EPS Target 9Health News:Aflac Incorporated Announces Fourth Quarter Results, Sees 2008 RBC Ratio Above 450%, Affirms 2009 Operating EPS Target 10Health News:Aflac Incorporated Announces Fourth Quarter Results, Sees 2008 RBC Ratio Above 450%, Affirms 2009 Operating EPS Target 11Health News:Aflac Incorporated Announces Fourth Quarter Results, Sees 2008 RBC Ratio Above 450%, Affirms 2009 Operating EPS Target 12Health News:Aflac Incorporated Announces Fourth Quarter Results, Sees 2008 RBC Ratio Above 450%, Affirms 2009 Operating EPS Target 13Health News:Aflac Incorporated Announces Fourth Quarter Results, Sees 2008 RBC Ratio Above 450%, Affirms 2009 Operating EPS Target 14Health News:Aflac Incorporated Announces Fourth Quarter Results, Sees 2008 RBC Ratio Above 450%, Affirms 2009 Operating EPS Target 15Health News:Rochester Medical Reports First Quarter Results 2Health News:Rochester Medical Reports First Quarter Results 3Health News:Rochester Medical Reports First Quarter Results 4Health News:Rochester Medical Reports First Quarter Results 5Health News:Rochester Medical Reports First Quarter Results 6Health News:Rochester Medical Reports First Quarter Results 7Health News:Rochester Medical Reports First Quarter Results 8Health News:DURECT Corporation Invites You to Join Its Fourth Quarter 2008 Earnings Conference Call 2
(Date:5/24/2013)... May 24, 2013  Regulatory and marketplace changes ... many organizations, priority list. Forward-thinking ... understand a strong Medical Affairs function ... development, market education , and regulatory compliance. ... vital bridge between an organization and one of ...
(Date:5/24/2013)... May 24, 2013  BD (Becton, Dickinson and Company) (NYSE: ... announced today that it will present at the Deutsche Bank ... 30, 2013, at 10:40 a.m. (ET). A ... BD corporate website at www.bd.com/investors and will be ... About BD BD is a leading global ...
(Date:5/24/2013)... 2013 /PRNewswire-iReach/ -- Phoenix Houses of California ... organization, is hosting its tenth annual "Triumph For Teens" ... 6, 2013.  More than 300 people are expected to ... residential treatment centers, family therapy, and prevention programs of ... have positive influences on the health and welfare of our ...
Breaking Medicine Technology:Building Medical Affairs Capabilities to Ensure Organizational Success across Key Operational Areas 2Phoenix House Honors Allergan Chairman David Pyott And Legendary Sports Agent And Humanitarian, Leigh Steinberg 2Phoenix House Honors Allergan Chairman David Pyott And Legendary Sports Agent And Humanitarian, Leigh Steinberg 3
... scientists today,report that the genetic variant on chromosome ... of heart attack is also associated with up ... (AAA) and intracranial,aneurysm (IA). This is the first ... condition. The paper, entitled ,The same sequence,variant on ...
... Jan. 3 Watson,Pharmaceuticals, Inc. (NYSE: WPI ... has launched Clarithromycin Extended-Release,Tablets, USP in the 500 ... equivalent to Abbott,s Biaxin(R),XL, which is indicated to ... suspected to be caused by susceptible bacteria. For ...
Cached Medicine Technology:Not Only Lipids and Inflammation: Insight Into a New Cause of Heart Attack and Other Vascular Disease 2Not Only Lipids and Inflammation: Insight Into a New Cause of Heart Attack and Other Vascular Disease 3Watson Launches Generic Biaxin(R) XL 2
Blood grouping tubes are available in two formulations, ACD-A, ACD-B or with a CPDA solution. Blood grouping tubes are for blood grouping determinations and also for cell preservation....
BD Vacutainer® Specialty Tubes - Other - Plastic...
The Erythrocyte Sedimentation Rate (ESR) can be used as a nonspecific search technique in case of suspicion of inflammatory reactions as well as for judgement of their development. VACUETTE® ESR...
Inquire...
Medicine Products: