Navigation Links
Novel mouse model for autism yields clues to a 50-year-old mystery
Date:3/20/2012

Early disruptions in serotonin signaling in the brain may contribute to autism spectrum disorder (ASD), and other "enduring effects on behavior," Vanderbilt University researchers report.

Serotonin is a brain chemical that carries signals across the synapse, or gap between nerve cells. The supply of serotonin is regulated by the serotonin transporter (SERT). In 2005, a team of Vanderbilt researchers led by Randy Blakely and James Sutcliffe identified rare genetic variations in children with ASD that disrupt SERT function.

In a new study published this week in the Proceedings of the National Academy of Sciences (PNAS), the researchers report the creation of a mouse model that expressed the most common of these variations.

The change is a very small one in biochemical terms, yet it appears to cause SERT in the brain to go into "overdrive" and restrict the availability of serotonin at synapses.

"The SERT protein in the brain of our mice appears to exhibit the exaggerated function and lack of regulation we saw using cell models," said Blakely, director of the Vanderbilt Silvio O. Conte Center for Neuroscience Research.

"Remarkably, these mice show changes in social behavior and communication from early life that may parallel aspects of ASD," noted first author Jeremy Veenstra-VanderWeele, assistant professor of Psychiatry, Pediatrics and Pharmacology.

The researchers conclude that a lack of serotonin during development may lead to long-standing changes in the way the brain is "wired."

In 1961, investigators at Yale discovered that as many as 30 percent of children with autism have elevated blood levels of serotonin, a finding described as "hyperserotonemia."

Since then, these findings have been replicated many times. Indeed, hyperserotonemia is the most consistently reported biochemical finding in autism, and is a highly inherited trait. Yet, the cause or significance of this "
'/>"/>

Contact: Bill Snyder
william.snyder@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Unprecedented academic-industry collaboration seeks new drugs and novel treatments for autism
2. Novel plastics and textiles from waste with the use of microbes
3. UC San Diego among first in nation to treat brain cancer with novel viral vector
4. Students at Western University develop a novel way to teach interdisciplinary care
5. UH Case Medical Center publishes study on novel treatment for skin lymphoma
6. Mass. General researchers find novel way to prevent drug-induced liver injury
7. Rutgers, Massachusetts General investigators find novel way to prevent drug-induced liver injury
8. NIH scientists identify novel approach to view inner workings of viruses
9. Novel Stem Cell Treatment May Hold Promise for Type 1 Diabetes
10. KalVista and JDRF form research partnership for novel treatment of diabetic eye disease
11. Novel brain tumor vaccine acts like bloodhound to locate cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel mouse model for autism yields clues to a 50-year-old mystery
(Date:5/23/2015)... Injury lawyer Steven H. Heisler commented today on ... Maryland legislature but which has not been signed to date ... HB 449 with overwhelming bipartisan support on April 10, ... law. This bill ensures that fracking is prohibited in Maryland ... danger of fracking to our water supplies and the air ...
(Date:5/22/2015)... San Francisco, CA (PRWEB) May 22, 2015 ... is hosting two exciting events in June. They will ... First Professional Doctorate and a two-day class on Classical ... 1:30-2:30 p.m. June 3, Dr. Steve Given, the Dean ... he will discuss the new First Professional Doctorate program. ...
(Date:5/22/2015)... York, New York (PRWEB) May 22, 2015 ... http://www.xareltolawsuit2015.com/ ) filed on behalf of individuals who ... due to its use continue to move forward ... Louisiana. According to a Pretrial Order dated May ... the preservation of documents and electronically stored information. ...
(Date:5/22/2015)... 22, 2015 Combination therapy, or ... for chronic obstructive pulmonary disorder (COPD) as the ... AstraZeneca plc as well as Germany’s Boehringer Ingelheim ... position. But will market payers, clinicians and patients ... products to completely new ones? , In spite ...
(Date:5/22/2015)... Family, friends, students, colleagues, mentors and fellow physicians ... D. Leffall, on Monday, May 18, with an 85th ... in the hospital’s Tower Auditorium. Leffall’s younger sister, 83-year-old ... to keep the secret. “I’d like to go in ... know something is up,” she said. , After more ...
Breaking Medicine News(10 mins):Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 3Health News:ACTCM Announces Upcoming June Events 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 3Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 4Health News:Chronic Obstructive Pulmonary Disorder Therapeutics Market Discussed in In-demand FirstWord Report Published at MarketPublishers.com 2Health News:Colleagues Surprise Dr. LaSalle Leffall with 85th Birthday Celebration 2
... fifth largest journal publisher, is proud to be participating ... Development launched today by the Council of Science Editors. ... awareness and stimulate interest and debate on the crucial ... journals from both developed and developing countries will simultaneously ...
... IL, October 22, 2007) Hospitalized patients who smoke ... use of hypnotherapy than patients using other smoking cessation ... 73rd annual international scientific assembly of the American College ... participated in one hypnotherapy session were more likely to ...
... Lawrence, UCLA,s chief of vascular surgery, picks up size 7 crochet ... scarves but to use in a new technique he has developed ... of the new outpatient procedure, called light-assisted stab phlebectomy, or LASP, ... The American Surgeon. , More than 250 ...
... PITTSBURGH, Oct. 22 InformationWeek magazine, one of,the ... 62nd in its annual ranking of the top ... ranked second in the health insurance field and,fourth ... the rankings from,170th last year. Tom Tabor, ...
... 31, 2007 Win: Cash prize of $1000 ... Immunology (AAAAI), the,largest professional medical specialty organization in ... allied,health professionals and others with a special interest ... now accepting entries for the 2007 Annual,Samter Journalism ...
... all the difference, report finds , , MONDAY, Oct. 22 ... saved by a coordinated global effort to improve nutrition ... fuels in underdeveloped countries, a new study finds. , ... of almost 1.5 million children in sub-Saharan Africa, 800,000 ...
Cached Medicine News:Health News:9 SAGE journals participate in global theme issue on poverty and human development 2Health News:Hypnosis for smoking cessation sees strong results 2Health News:UCLA doctor develops new technique to treat varicose veins 2Health News:UCLA doctor develops new technique to treat varicose veins 3Health News:National Magazine Ranks Highmark 62nd Among Nation's 500 Most Innovative Users of Information Technology 2Health News:Call for Entries: 2007 AAAAI Annual Samter Journalism Awards 2Health News:Saving Millions of Children's Lives Is Possible 2
(Date:5/22/2015)... 2015 Today, Rhodes Pharmaceuticals L.P. announced that ... indicated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) ... The announcement comes just one ... U.S. Food and Drug Administration (FDA). ... methylphenidate capsule with an onset of effect of ...
(Date:5/21/2015)... 2015 Research and ... addition of the "North American Joint ... Replacement, Elbow Replacement, Hip Replacement, Knee Replacement, ... report to their offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... valued at $4,470.9 million in 2014 and ...
(Date:5/21/2015)... ATLANTA , May 21, 2015  CryoLife, Inc. ... tissue processing company focused on cardiac and vascular surgery, ... a quarterly cash dividend for the second quarter 2015 ... quarterly cash dividend of $0.03 per share will be ... of record as of June 12, 2015.  The ex-dividend ...
Breaking Medicine Technology:Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 2Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 3Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 4Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 5Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 6North American Joint Reconstruction Market 2015-2019 - Zimmer Holdings, DePuy Synthes Companies, Stryker, Biomet & Smith & Nephew Dominates the $4.4 Billion Market 2CryoLife Announces Quarterly Cash Dividend for the Second Quarter 2015 2
... inception in 2007, the world’s leading medical technology ... this year’s conference was no exception. Compared with ... up nearly 12 percent, CEO-level participation rose five ... fifth annual conference also drew attendees from 22 ...
... Oct. 5, 2011 myMatrixx®, a full-service pharmacy and ... today that Phil Walls, R.Ph., Chief Clinical & Compliance ... awards programs. The first is Health Care Heroes hosted ... is a finalist in the Medical Professional Non-Physician category. ...
Cached Medicine Technology:Annual AdvaMed MedTech Conference Continues Impressive Growth 2Annual AdvaMed MedTech Conference Continues Impressive Growth 3myMatrixx's Phil Walls, R.Ph. Receives National and Regional Recognition 2
... BacT/Alert 3D Signature is a state ... system that integrates blood, sterile body ... a powerful microbiology workstation with comprehensive ... volume identification and where expanded flexibility ...
... 3D Select is a state ... detection system that integrates blood, ... culturing. This system is useful ... laboratory information system (LIS) connectivity ...
The Vitek 2 - XL is a fully automated bacteriology system that performs bacterial identification and susceptibility testing analysis using a standard inoculum. It detects resistance and helps combat ...
IDS Rapid ANA II System, a microbial identification system....
Medicine Products: