Navigation Links
Novel mouse model for autism yields clues to a 50-year-old mystery
Date:3/20/2012

Early disruptions in serotonin signaling in the brain may contribute to autism spectrum disorder (ASD), and other "enduring effects on behavior," Vanderbilt University researchers report.

Serotonin is a brain chemical that carries signals across the synapse, or gap between nerve cells. The supply of serotonin is regulated by the serotonin transporter (SERT). In 2005, a team of Vanderbilt researchers led by Randy Blakely and James Sutcliffe identified rare genetic variations in children with ASD that disrupt SERT function.

In a new study published this week in the Proceedings of the National Academy of Sciences (PNAS), the researchers report the creation of a mouse model that expressed the most common of these variations.

The change is a very small one in biochemical terms, yet it appears to cause SERT in the brain to go into "overdrive" and restrict the availability of serotonin at synapses.

"The SERT protein in the brain of our mice appears to exhibit the exaggerated function and lack of regulation we saw using cell models," said Blakely, director of the Vanderbilt Silvio O. Conte Center for Neuroscience Research.

"Remarkably, these mice show changes in social behavior and communication from early life that may parallel aspects of ASD," noted first author Jeremy Veenstra-VanderWeele, assistant professor of Psychiatry, Pediatrics and Pharmacology.

The researchers conclude that a lack of serotonin during development may lead to long-standing changes in the way the brain is "wired."

In 1961, investigators at Yale discovered that as many as 30 percent of children with autism have elevated blood levels of serotonin, a finding described as "hyperserotonemia."

Since then, these findings have been replicated many times. Indeed, hyperserotonemia is the most consistently reported biochemical finding in autism, and is a highly inherited trait. Yet, the cause or significance of this "
'/>"/>

Contact: Bill Snyder
william.snyder@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Unprecedented academic-industry collaboration seeks new drugs and novel treatments for autism
2. Novel plastics and textiles from waste with the use of microbes
3. UC San Diego among first in nation to treat brain cancer with novel viral vector
4. Students at Western University develop a novel way to teach interdisciplinary care
5. UH Case Medical Center publishes study on novel treatment for skin lymphoma
6. Mass. General researchers find novel way to prevent drug-induced liver injury
7. Rutgers, Massachusetts General investigators find novel way to prevent drug-induced liver injury
8. NIH scientists identify novel approach to view inner workings of viruses
9. Novel Stem Cell Treatment May Hold Promise for Type 1 Diabetes
10. KalVista and JDRF form research partnership for novel treatment of diabetic eye disease
11. Novel brain tumor vaccine acts like bloodhound to locate cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel mouse model for autism yields clues to a 50-year-old mystery
(Date:8/20/2014)... Salt Lake City, Utah (PRWEB) August 20, 2014 ... House Awning & Canvas Products, announces the availability ... extension of the company’s ordering capabilities aims to ... features Sugar House Awning’s complete line of canvas ... most major brands including Bryant, Lennox, Rheem, Payne, ...
(Date:8/20/2014)... 2014 Recently, UWDress.com, the distinguished wedding ... of birthday party dresses for girls . According ... well-designed and exquisitely handmade by experienced specialists. Now, they ... off. , The company’s new items come in various ... knee length frocks, long elegant backless gowns and so ...
(Date:8/20/2014)... Top10BestSEOHosting.com is a website dedicated to ... It is headed by a team of experts ... research-based information and factual studies about the newest ... market. , Recently, Top10BestSEOHosting.com has compared many ... and Bluehost are the most recommended suppliers ...
(Date:8/20/2014)... Park Avenue Dental, a leading Florida-based dental ... top graduate of the University of Detroit School of ... website through an ultra-informative blog focused on dental tips ... the blog page is chock full of topics that ... concentrating on important dental care tips including ...
(Date:8/20/2014)... 20, 2014 Today, Zane Benefits, ... publication of a new eBook, Affordable Care Act ... business owners feel uncertain about how the ACA ... their bottom line. , The new eBook outlines ... businesses navigate their upcoming health insurance decisions. , ...
Breaking Medicine News(10 mins):Health News:Air Conditioner Covers for Most A/C Units Now Available Online at Coolercovers.com and Amazon.com 2Health News:Air Conditioner Covers for Most A/C Units Now Available Online at Coolercovers.com and Amazon.com 3Health News:Cheap Birthday Party Dresses for Girls Now Available at UWDress.com 2Health News:New Reviews For Linux Web Hosting Suppliers Announced By Top10BestSEOHosting.com 2Health News:Park Avenue Dental Provides Dental Care Tips for World Wide Community on New Website Blog 2Health News:Park Avenue Dental Provides Dental Care Tips for World Wide Community on New Website Blog 3
... injection into a collection of nerves in the neck ... frequency of debilitating hot flashes and night awakenings associated ... published online today by The Lancet Oncology and appearing ... dysfunctions often plague breast cancer survivors, especially those who ...
... WASHINGTON, May 14 The following was,released by the ... Obama:, "NARAL Pro-Choice America PAC Is Excited To ... 2008. Sen. Obama Has A Fully Pro-Choice,Record, And We ... Champion For,Women,s Reproductive Rights." (NARAL Website, "Elections," http://www.naral.org, ...
... Center, Emory University, have discovered the first conclusive ... aged nonhuman primate. The unprecedented finding, described in ... Neurology, has the potential to move the scientific ... neurodegenerative diseases, such as Alzheimer,s disease, are uniquely ...
... Mergent, Inc., administrator for the,HealthShares(TM) Indexes, a ... Traded Funds, today announced the following,changes with effect ... 19, 2008:,Genzyme Corporation (Nasdaq: GENZ ) will ... Index, Ligand Pharmaceuticals Inc.,(Nasdaq: LGND ) will ...
... They contain same toxins as cigarettes, but users think ... News) -- The increasing use of waterpipes, or ... public health problem, according to a Virginia Commonwealth University ... and the smoke is cooled by passing through a ...
... can lead to muscle spasms, fever, sweating and nausea, ... A commonly used migraine medication may cause so-called serotonin ... in the May 15 issue of the New ... and the U.S. Food and Drug Administration detail 11 ...
Cached Medicine News:Health News:'Cool' new treatment for hot flashes in breast cancer survivors 2Health News:'Cool' new treatment for hot flashes in breast cancer survivors 3Health News:NARAL'S CHOICE: Is Anyone Surprised About Out-of-the-Mainstream NARAL's Choice of Barack Obama for President? 2Health News:NARAL'S CHOICE: Is Anyone Surprised About Out-of-the-Mainstream NARAL's Choice of Barack Obama for President? 3Health News:Researchers find first conclusive evidence of Alzheimer's-like brain tangles in nonhuman primates 2Health News:Researchers find first conclusive evidence of Alzheimer's-like brain tangles in nonhuman primates 3Health News:Mergent, Inc. Announces Changes to the HealthShares(TM) Composite Index, HealthShares(TM) Dermatology and Wound Care Index and HealthShares(TM) Orthopedic Repair Index 2Health News:Mergent, Inc. Announces Changes to the HealthShares(TM) Composite Index, HealthShares(TM) Dermatology and Wound Care Index and HealthShares(TM) Orthopedic Repair Index 3Health News:Waterpipe Smoking in Colleges Could Become Public Health Problem 2Health News:Migraine Medications May Cause 'Serotonin Syndrome' 2Health News:Migraine Medications May Cause 'Serotonin Syndrome' 3
(Date:8/20/2014)... 20, 2014 ApolloDx™ today announced it will ... a special event at the company,s office in ... 5, 2014. The event, which will start at 10:00 ... www.apollodx.com .    "We believe our ... Jared Bauer , Co-Founder and Managing Partner of ApolloDx. ...
(Date:8/20/2014)... DIEGO , Aug. 20, 2014 Trovagene, ... diagnostics, announced today that results from two clinical studies ... conference for the Company,s urine-based diagnostic test for the ... The IPV conference is scheduled to take place in ... to 25 th . Additionally, a new U.S. ...
(Date:8/20/2014)... August 20, 2014 Phase I ... the US  KalVista Pharmaceuticals ("KalVista"), an ophthalmology ... today announces that it has begun a Phase I, ... inhibitor, KVD001, for the treatment of DME. The study,s ... Beetham Eye Institute, Joslin Diabetes Center; Harvard Medical School ...
Breaking Medicine Technology:Trovagene Provides Update on Its Urine-Based HPV Test 2Trovagene Provides Update on Its Urine-Based HPV Test 3KalVista Pharmaceuticals Announces Start of Clinical Development for Novel Treatment for Diabetic Macular Edema 2KalVista Pharmaceuticals Announces Start of Clinical Development for Novel Treatment for Diabetic Macular Edema 3KalVista Pharmaceuticals Announces Start of Clinical Development for Novel Treatment for Diabetic Macular Edema 4
... Therapies, Inc. (ITI),today announced it has initiated a ... its drug candidate ITI-722. ITI-722 acts predominantly,as a ... new,approach to the treatment of SMI. Because of ... activities, ITI believes, ITI-722 can be,used not only ...
... GeoVax Labs, Inc. (OTC,Bulletin Board: GOVX), an ... it has retained Financial,Relations Board (FRB), as its ... promising HIV-1/AIDS vaccine human trial results need to ... catastrophic AIDS,pandemic," stated Kathy Waller, co-president of FRB., ...
Cached Medicine Technology:Intra-Cellular Therapies Initiates Phase 2 Clinical Trial for Sleep Maintenance Insomnia 2Intra-Cellular Therapies Initiates Phase 2 Clinical Trial for Sleep Maintenance Insomnia 3Intra-Cellular Therapies Initiates Phase 2 Clinical Trial for Sleep Maintenance Insomnia 4GeoVax Labs, Inc. Selects Financial Relations Board as Investor Relations Counsel 2GeoVax Labs, Inc. Selects Financial Relations Board as Investor Relations Counsel 3GeoVax Labs, Inc. Selects Financial Relations Board as Investor Relations Counsel 4
... concave seats and large backrests with ... seats, backrests, armrests, and casters and ... for top performance in a variety ... clean room, static control, health care ...
... chairs with concave seats and large backrests ... seats, backrests, armrests, and casters and glides. ... performance in a variety of environments including: ... health care and office. • With cast ...
... Durable ergonomic chairs with concave ... support • Select options like seats, ... • Choose the BE Series for ... environments including: industry, education, laboratory, clean ...
... chairs with concave seats and large backrests ... seats, backrests, armrests, and casters and glides. ... performance in a variety of environments including: ... health care and office. • With tubular ...
Medicine Products: