Navigation Links
Novel mouse model for autism yields clues to a 50-year-old mystery
Date:3/20/2012

Early disruptions in serotonin signaling in the brain may contribute to autism spectrum disorder (ASD), and other "enduring effects on behavior," Vanderbilt University researchers report.

Serotonin is a brain chemical that carries signals across the synapse, or gap between nerve cells. The supply of serotonin is regulated by the serotonin transporter (SERT). In 2005, a team of Vanderbilt researchers led by Randy Blakely and James Sutcliffe identified rare genetic variations in children with ASD that disrupt SERT function.

In a new study published this week in the Proceedings of the National Academy of Sciences (PNAS), the researchers report the creation of a mouse model that expressed the most common of these variations.

The change is a very small one in biochemical terms, yet it appears to cause SERT in the brain to go into "overdrive" and restrict the availability of serotonin at synapses.

"The SERT protein in the brain of our mice appears to exhibit the exaggerated function and lack of regulation we saw using cell models," said Blakely, director of the Vanderbilt Silvio O. Conte Center for Neuroscience Research.

"Remarkably, these mice show changes in social behavior and communication from early life that may parallel aspects of ASD," noted first author Jeremy Veenstra-VanderWeele, assistant professor of Psychiatry, Pediatrics and Pharmacology.

The researchers conclude that a lack of serotonin during development may lead to long-standing changes in the way the brain is "wired."

In 1961, investigators at Yale discovered that as many as 30 percent of children with autism have elevated blood levels of serotonin, a finding described as "hyperserotonemia."

Since then, these findings have been replicated many times. Indeed, hyperserotonemia is the most consistently reported biochemical finding in autism, and is a highly inherited trait. Yet, the cause or significance of this "
'/>"/>

Contact: Bill Snyder
william.snyder@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Unprecedented academic-industry collaboration seeks new drugs and novel treatments for autism
2. Novel plastics and textiles from waste with the use of microbes
3. UC San Diego among first in nation to treat brain cancer with novel viral vector
4. Students at Western University develop a novel way to teach interdisciplinary care
5. UH Case Medical Center publishes study on novel treatment for skin lymphoma
6. Mass. General researchers find novel way to prevent drug-induced liver injury
7. Rutgers, Massachusetts General investigators find novel way to prevent drug-induced liver injury
8. NIH scientists identify novel approach to view inner workings of viruses
9. Novel Stem Cell Treatment May Hold Promise for Type 1 Diabetes
10. KalVista and JDRF form research partnership for novel treatment of diabetic eye disease
11. Novel brain tumor vaccine acts like bloodhound to locate cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel mouse model for autism yields clues to a 50-year-old mystery
(Date:8/1/2015)... ... ... 2015 Phil Valentine – the Executive Director of Connecticut Community for Addiction Recovery (CCAR) – ... Mountain and heading north. Since that day, Phil has hiked over 1400 miles in nine ... and family. He visited CCAR and left an inspirational message to his staff: “You ...
(Date:7/31/2015)... ... ... Down is a reputable source of authentic tickets for the 2015 iHeart Radio Music ... genre of music will have an act they are excited to see at this two-day ... artists will perform: Sam Smith, Coldplay, Kenny Chesney, The Who, Jason Derulo, Demi Lovato, ...
(Date:7/31/2015)... ... August 01, 2015 , ... The Honor Society of Nursing, ... on the Future of Nursing (GAPFON) 20-21 July 2015 in San Juan, Puerto Rico. ... this meeting. , Dr. Silvia Cassiani, Advisor, Nursing and Allied Health Personnel Development, Unit ...
(Date:7/31/2015)... ... July 31, 2015 , ... Ticket Down is a ... going on in Chicago at Grant Park. The festival will end on Sunday, ... America to Chicago for the annual Lollapalooza. This unique and unbelievably popular festival ...
(Date:7/31/2015)... ... July 31, 2015 , ... Recently touted by ... predictive health analytics , Jvion continues to disrupt the predictive analytic and ... that targets patient and population level illness to drive prevention and better health ...
Breaking Medicine News(10 mins):Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 4Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2Health News:Jvion Showcased as Leader in the Predictive Analytic Market 2
... A study by the computational neuroscientist of Vanderbilt University ... an insight into neural circuits that play a role ... that make us apply previously learned rules on new ... feel that the new use of technology in understanding ...
... the grapefruit seeds contain antioxidants that help to ... had been associated with acidity and gastrointestinal irritation, ... that have healing properties. Researchers from Poland, who ... study findings at the Digestive Disease Week meeting, ...
... cancer after undergoing surgery can reduce the risk of recurrence// ... presented at the annual meeting of American Society of Clinical ... 50% for the patients who took regular aspirin after surgery, ... ,Colon and rectum together form the colorectal area. That is ...
... for people whose blood pressure do not lower //during night ... a healthy normal person blood pressure tends to lower while ... disturbances may elevate the nighttime blood pressures. ,The ... of blood pressure at night may be the predictor for ...
... out that certain ordinary drugs like//anti-psychotic and gastro-intestinal drugs ... study, which was published in the European Heart Journal, ... activity controlling heartbeats that can increase the risk of ... can prolong the duration of electrical activity that controls ...
... or nocturnal gastro esophageal reflux may be due// to ... ,Nocturnal heartburns often lead to disturbed sleep and excessive ... other disease. Nocturnal gastro esophageal reflux or heartburn is ... disease. ,Researchers of University of Arizona College ...
Cached Medicine News:
(Date:7/30/2015)... 2015  Tandem Diabetes Care®, Inc. (NASDAQ: ... of the t:slim® and t:flex™ Insulin Pumps, today ... Agreements with Dexcom, Inc. to allow the integration ... Dexcom G5 and G6 continuous glucose monitoring ("CGM") ... platform with Dexcom,s future CGM systems is an ...
(Date:7/30/2015)... N.J. , July 30, 2015  Unichem Pharmaceuticals ... recalling one lot of Hydrochlorothiazide tablets 25 mg 1000-count ... initiated as a precautionary measure due to the identification ... the product. The risk associated with ... tablet is the increased probability of experiencing Clopidogrel,s side ...
(Date:7/30/2015)... PTC Therapeutics, Inc. (NASDAQ: PTCT ) ... for the second quarter ending June 30, 2015. ... the organization.  We are excited to be near the ... ever conducted with topline results expected in the fourth ... PTC Therapeutics, Inc. "Translarna is now commercially available in ...
Breaking Medicine Technology:Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 2Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 3Unichem Pharmaceuticals (USA), Inc. Issues a Voluntary Nationwide Recall of Hydrochlorothiazide Tablets Due to the Potential Presence of Foreign Tablets 2PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 2PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 3PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 4PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 5PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 6PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 7PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 8PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 9PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 10
... MYL ) today announced that its subsidiary Matrix Laboratories ... Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) ... mg, the generic version of Pfizer,s Neurontin ® Capsules ... Gabapentin Capsules had U.S. sales of approximately $300 million ...
... 2011 PAREXEL International Corporation (Nasdaq: ... the Raymond James Investors Conference in Orlando, FL.  James Winschel, ... a presentation on PAREXEL at 2:50 p.m.  ET on Monday, ... presentation will be available through the "Investors" section ...
Cached Medicine Technology:PAREXEL International to Present at Raymond James Investors Conference 2
The Vision Premier software features advanced,capabilities, including automatic categorization,of beats, tachogram review and full-disclosure,viewing, providing the tools needed for even,the ...
The Deltec Cozmo® insulin pump is small, about the size of a cell phone, and only weighs 3.3 ounces (w/ battery and full cartridge). Its ergonomic design fits comfortably in the palm of your han...
The IR 1000 Insulin Infusion Pump from Animas offers unprecedented safety features, performance, and convenience....
... was designed specifically to meet the varying needs ... a simple to use, compact, dual application system ... field of light based hair removal. SpaTouch works ... safe for use on nearly all face and ...
Medicine Products: