Navigation Links
Novel model of osteosarcoma
Date:6/14/2008

In the June 15th issue of G&D, Dr. Stuart Orkin (HHMI, Dana-Farber Cancer Institute, Children's Hospital Boston) and colleagues present a new mouse model of osteosarcoma.

Osteosarcoma is the most common type of malignant bone cancer, and one of the most lethal: The 5-year survival rate is only about 60%, and this statistic drops steeply once the cancer spreads. Osteosarcoma results from the dysregulated growth of osteoblasts (the cells that form the bone matrix). It primarily develops near the ends of the femur, tibia or humerus, and is usually diagnosed during adolescence, when the long bones of the body are undergoing rapid growth.

While the precise causes of osteosarcoma are unknown, it is evident that two tumor suppressor genes p53 and Rb are involved, as children with familial mutation syndromes affecting either of these genes have higher incidences of osteosarcoma.

Dr. Orkin's team has developed a novel experimental system to model the genetics of human osteosarcoma. The researchers generated a strain of transgenic mice lacking specifically the p53 and Rb genes in an early osteoblast progenitor cell population. All mutant animals rapidly developed osteosarcomas, with clinical, histo-cytological and molecular features closely recapitulating the human disease.

The scientists concluded that p53 loss is essential for the development of osteosarcoma, and that while Rb gene mutation acts synergistically with p53 loss to facilitate carcinogenesis, loss of Rb, alone, is not sufficient to induce osteosarcomagenesis.

Ultimately, this high-fidelity animal model will further elucidate the genetic contributions to osteosarcoma, and enable researchers to rationally design and test new therapies. Dr. Orkin is hopeful that "our work will stimulate translational efforts to develop novel therapies for this devastating bone tumor".


'/>"/>

Contact: Heather Cosel-Pieper
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related medicine news :

1. Novel DNA microarray chip predicts functional impairment and remission in rheumatoid arthritis
2. Who Knew You Could Learn to Lose Weight by Reading an Enjoyable Novel?
3. OHSU Cancer Institute researchers find novel chemo drug helps treat prostate cancer
4. Combination of 2 novel anti-cancer agents may help fight CML resistant to current therapy
5. USC researchers identify genetic markers that predict efficacy of novel cancer drug
6. Farmington Hills Plastic Surgeon Uses Novel Procedure: Patients Own Fat From Liposuction for Buttock Enhancement
7. Novel toxin receptor discovered for ulcer-causing stomach pathogen
8. Novel enzyme inhibitor paves way for new cancer drug
9. Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting
10. Novel mechanisms controlling insulin release and fat deposition discovered
11. Preliminary Results from Phase 2 Genzyme Study Highlight Potential of Novel Oral Compound for Gaucher Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... ... 2017 , ... Permobil has just completed the acquisition of ... systems has a well-earned reputation for premium quality, with a focus on fit ... in the custom seating business, which enjoys strong demand, and it complements Permobil’s ...
(Date:1/16/2017)... ... ... Louisans are well-aware of the following facts at present:, Flu ... having no effect on keeping this particularly bad strain of the flu away , ... or sniffling , These facts are well-known among the team at Woodard! ...
(Date:1/16/2017)... , ... January 16, 2017 , ... ... to provide first-quality education and high-level training standards to an international multidisciplinary group ... eating disorder problems. As a way to further its mission at the grassroots ...
(Date:1/16/2017)... ... 16, 2017 , ... Vixiar Medical, Inc. announced ... device company, effective immediately. , “This is perfect timing for Kevin to come ... record in medical device market development and revenue growth, particularly in building new ...
(Date:1/15/2017)... (PRWEB) , ... January 15, 2017 , ... ... Gensuite’s Community Outreach is a program that strives to better communities around the ... global locations’ community. It also provides the opportunity for team members to become ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... YORK , January 13, 2017 ... equities: Wright Medical Group N.V. (NASDAQ: WMGI ), ... Group Inc. (NASDAQ: MDXG ), and NuVasive Inc. ... Healthcare sector which fell back to a negative finish on ... Care Index falling about 0.1%, while shares of health care ...
(Date:1/13/2017)... 13, 2017  Alfalfa, cattle, leafy greens and rosy cheeked ... film , which emphasizes the food industry,s shift from response ... COPAN,s Swab Rinse Kit (SRK™) ... sampling process in the wake of the new FDA ... COPAN is expanding the U.S. production of the ...
(Date:1/13/2017)... January 13, 2017 On Thursday, ... Industrial Average, and the S&P 500 edged lower at ... Thursday,s trading session in bearish territories. Taking into consideration ... equities this morning: Myriad Genetics Inc. (NASDAQ: ... INC Research Holdings Inc. (NASDAQ: INCR ), ...
Breaking Medicine Technology: