Navigation Links
Novel model of osteosarcoma
Date:6/14/2008

In the June 15th issue of G&D, Dr. Stuart Orkin (HHMI, Dana-Farber Cancer Institute, Children's Hospital Boston) and colleagues present a new mouse model of osteosarcoma.

Osteosarcoma is the most common type of malignant bone cancer, and one of the most lethal: The 5-year survival rate is only about 60%, and this statistic drops steeply once the cancer spreads. Osteosarcoma results from the dysregulated growth of osteoblasts (the cells that form the bone matrix). It primarily develops near the ends of the femur, tibia or humerus, and is usually diagnosed during adolescence, when the long bones of the body are undergoing rapid growth.

While the precise causes of osteosarcoma are unknown, it is evident that two tumor suppressor genes p53 and Rb are involved, as children with familial mutation syndromes affecting either of these genes have higher incidences of osteosarcoma.

Dr. Orkin's team has developed a novel experimental system to model the genetics of human osteosarcoma. The researchers generated a strain of transgenic mice lacking specifically the p53 and Rb genes in an early osteoblast progenitor cell population. All mutant animals rapidly developed osteosarcomas, with clinical, histo-cytological and molecular features closely recapitulating the human disease.

The scientists concluded that p53 loss is essential for the development of osteosarcoma, and that while Rb gene mutation acts synergistically with p53 loss to facilitate carcinogenesis, loss of Rb, alone, is not sufficient to induce osteosarcomagenesis.

Ultimately, this high-fidelity animal model will further elucidate the genetic contributions to osteosarcoma, and enable researchers to rationally design and test new therapies. Dr. Orkin is hopeful that "our work will stimulate translational efforts to develop novel therapies for this devastating bone tumor".


'/>"/>

Contact: Heather Cosel-Pieper
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related medicine news :

1. Novel DNA microarray chip predicts functional impairment and remission in rheumatoid arthritis
2. Who Knew You Could Learn to Lose Weight by Reading an Enjoyable Novel?
3. OHSU Cancer Institute researchers find novel chemo drug helps treat prostate cancer
4. Combination of 2 novel anti-cancer agents may help fight CML resistant to current therapy
5. USC researchers identify genetic markers that predict efficacy of novel cancer drug
6. Farmington Hills Plastic Surgeon Uses Novel Procedure: Patients Own Fat From Liposuction for Buttock Enhancement
7. Novel toxin receptor discovered for ulcer-causing stomach pathogen
8. Novel enzyme inhibitor paves way for new cancer drug
9. Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting
10. Novel mechanisms controlling insulin release and fat deposition discovered
11. Preliminary Results from Phase 2 Genzyme Study Highlight Potential of Novel Oral Compound for Gaucher Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... York, New York (PRWEB) December 25, 2014 ... the 2010 DePuy ASR hip recall ( http://www.consumerinjurylawyers.com/DePuy/ ) ... LLP reports. According to an Order issued in the ... 20th, the Court will convene an open conference on ... Building and United States Courthouse in West Palm Beach, ...
(Date:12/25/2014)... BellasDress has launched its Christmas Sale, offering ... chosen their best-selling lace wedding dresses, vintage bridesmaid dresses ... , Now, BellasDress.com features popular women’s dresses, and ... prices. The business hopes everyone can have a memorable ... “All our elegant products are made with exquisite materials; ...
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. 24, 2014 (HealthDay ... receive effective, less expensive care from a clinic that functions ... of dedicated health care professionals, a new study shows. ... either hospitalization or a trip to the emergency room when ... the University of Texas in Houston versus usual care, according ...
(Date:12/25/2014)... 25, 2014 AngelWeddingDress.com tries its best ... online realm. Today, the business has introduced its new ... prom dress promotion. , The new prom outfits are ... every dress lover. They are specially designed for 2015. ... dresses should visit its website before Jan. 26, ...
(Date:12/25/2014)... Santa Rosa, CA (PRWEB) December 25, 2014 ... emergency department visits and 2 million hospital admissions across ... Control and Prevention ). The CDC’s National Hospital ... emergency departments through a survey conducted in 2010. They ... emergency department visits that resulted in a primary diagnosis ...
Breaking Medicine News(10 mins):Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4
... bedside patient safety solutions -SAN DIEGO, April 3 ... handheld barcode point-of-care (BPOC) solutions ... Sweeney has been appointed Chairman and CEO.(Logo: ... CEO of eight healthcare service companies including Bridge ...
... boost strength in other ways, researchers say , , FRIDAY, April ... mass in octogenarian women but still helped them lift more ... University in Indiana finds. , , The six ... for three months on a machine designed to strengthen the ...
... F C, s * ... , Although recent media attention has focused on the presence of ... Protection Agency and the U.S. Food and Drug Administration (FDA) have ... appropriate for all consumers, including sensitive sub-populations like infants. Trace ...
... Inc. (Nasdaq: MEDQ ) has announced it has ... of Sales and Marketing. Gold will be responsible for ... of MedQuist. "We are pleased to have Alan join the ... brings an extensive knowledge and an in-depth understanding of healthcare ...
... poorer scores on cognitive tests , , FRIDAY, April 3 (HealthDay News) ... life span may be taking a toll on the brains of ... shows that women aged 47 to 74 who tested positive for ... or bones (an indication of cumulative exposure over the life span) ...
... & Spa,Group, Inc. (OTC Bulletin Board: SOKF) announced the ... April 1, 2009. The latest SOKO Spa began,offering "pre-opening" ... more,than 500 Spa members since that date. , ... Blessing Hot Spring Business Club,No.332, Xinyang Rd., Daoli District, ...
Cached Medicine News:Health News:James M. Sweeney Named Chairman and CEO of IntelliDOT 2Health News:James M. Sweeney Named Chairman and CEO of IntelliDOT 3Health News:James M. Sweeney Named Chairman and CEO of IntelliDOT 4Health News:Muscle Mass Won't Grow in Women Over 80 2Health News:International Formula Council (IFC) Reassures Parents about Perchlorate and the Safety of Infant Formula 2Health News:MedQuist Names Alan J. Gold as Senior Vice President, Sales and Marketing 2Health News:Accumulated Lead May Affect Older Women's Brains 2Health News:SOKO Fitness & Spa Group, Inc. Opens Xinyang Spa in Harbin 2
(Date:12/24/2014)... 2014 Echo Therapeutics, Inc. (NASDAQ: ... on skin permeation, continuous glucose monitoring and associated ... has been appointed Chief Executive Officer effective ... 20 years of experience in the medical device, ... served as Vice President, Business Development, Otsuka Pharmaceuticals as ...
(Date:12/24/2014)... 23, 2014   Assurex Health, a personalized ... healthcare providers for behavioral health and chronic pain ... million in equity financing from new and existing ... President and Chief Executive Officer. The ... of Assurex Health,s GeneSight ®  products.  ...
(Date:12/24/2014)... DUBLIN and RALEIGH, N.C. ... subsidiary of Endo International plc (NASDAQ: ENDP ... BDSI ) announced today that they have ... Buccal Film to the U.S. Food and Drug Administration ... the management of pain severe enough to require daily, ...
Breaking Medicine Technology:Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5
... Oct. 12 Ethicon Endo-Surgery, Inc., today ... at the 95th Annual Clinical Congress of the ... technologies of worldwide leading HARMONIC® ultrasonic and ENSEAL® ... delivery options that provide superior energy application for ...
... 12 Stereotaxis, Inc. (Nasdaq: STXS ) announced today ... Stereotaxis common stock have exercised in full their over-allotment option ... stock. The 7,475,000 shares of Stereotaxis common stock in ... option, are being sold at a price to the public ...
Cached Medicine Technology:Ethicon Endo-Surgery Unveils Full Energy Portfolio for First Time at American College of Surgeons Clinical Congress 2Ethicon Endo-Surgery Unveils Full Energy Portfolio for First Time at American College of Surgeons Clinical Congress 3Stereotaxis Announces Underwriters' Exercise of Over-Allotment Option 2Stereotaxis Announces Underwriters' Exercise of Over-Allotment Option 3
... The economical way to order tips. Each ... 1000 tips). Also available in easy-to-open, re-sealable ... Bulk Packs are sealed with a tamper-proof ... quick access to Gilsons Diamond Tips. Bulk ...
1000 L, Bulk Recommended for 500 and 1000 L pipettes....
1000 L, Bulk, blue Recommended for 500 and 1000 L pipettes....
Inquire...
Medicine Products: