Navigation Links
Novel method to reveal drug targets
Date:2/22/2008

from these proteins simply because there was no efficient method to examine them. Effectively, a swathe of clinically important targets is invisible to research.

"AVEXIS now allows us to scale the hunt for biologically and clinically important protein-protein interactions," continues Dr Wright. "These interactions are like Velcro - each hook can bind only weakly, but together, they can have a very strong effect. We increased the strength by gathering the proteins together, as in a small scrap of Velcro."

The team identified previously undescribed interactions in a class of proteins called the immunoglobulin superfamily: this group of proteins shares properties that are important to allow cells to respond to their environment, talk to one another and stick together. Using human proteins and zebrafish as a model, the Sanger Institute researchers looked at interactions between 110 proteins in this superfamily - a total of more than 6000 experiments.

They found 17 interactions that met stringent standards of reliability, several of which would last for less than 0.1 seconds in cells. For each, they looked to see where the proteins were located in zebrafish embryos. They found, broadly, two categories; those in which both protein partners are present in the same tissue (and likely to be involved in cell adhesion) and those in which they are present in adjoining tissues (and therefore likely to be involved in communication between tissues). Half of the proteins interact with more than one other protein, forming interaction networks.

The results provide the first network of low-affinity interactions between proteins on the cell surface and the first set of extensive data in the zebrafish, a leading organism for following visually the effects of gene disruption.

"AVEXIS is not restricted to only one specific organism and could be used in many contexts," explains Dr Wright. "We found in the zebrafish novel interactions for well-s
'/>"/>

Contact: Don Powell
don@sanger.ac.uk
44-012-234-96928
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
2. Novel virus detection identifies new viruses in study of respiratory infections and asthma attacks
3. Researchers uncover novel mechanism that balances the sizes of functional areas in the brain
4. Novel Cooling Therapy May Have Aided Injured Football Player
5. ECLIPSE data on effects of Otsukas investigational novel treatment, Tolvaptan
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. GrantAdler Shipping Novel Implantable Vascular Access Port
8. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
9. Novel strategy under study for aggressive leukemia
10. ISTO Technologies Receives 510(k) Clearance for a Novel Bone Graft Substitute and Bone Graft Extender
11. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Naples, Florida (PRWEB) September 18, 2014 Dr. ... in the nation, has expanded his services at Basile Plastic ... one of the most sought after treatments in the world ... pain or strain. , According to Dr. Basile, Coolsculpting ... do not wish to undergo a surgical procedure. He also ...
(Date:9/18/2014)... 18, 2014 The new BuildClean™ ... to contractors and homeowners alike as it eliminates ... the home, causes potential health issues, and makes ... the BuildClean system allows contractors to virtually eliminate ... other standard remodeling tasks. , BuildClean removes up ...
(Date:9/18/2014)... HealthDay Reporter WEDNESDAY, Sept. 17, 2014 ... post-traumatic stress disorder symptoms are almost three times more likely ... The findings don,t prove a direct link between ... it,s also possible that certain women are prone to food ... the research seems to add to existing evidence connecting PTSD ...
(Date:9/18/2014)... CA (PRWEB) September 18, 2014 A positive ... stress and improve your health. This year, at the Weekend ... to announce that adored LA radio talk show host Mother ... when living with diabetes. , The always-funny Jo Anne ... and is best known for her widely acclaimed talk show ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 Finding the ... leaving many dieters feeling that their weight loss struggle ... specially trained in the science of fast weight loss, ... without negative side effects. In fact, a recent in-house ... lost an average of 20 pounds during the first ...
Breaking Medicine News(10 mins):Health News:Naples Plastic Surgeon Introduces Pain-free Fat Removal Technique 2Health News:Naples Plastic Surgeon Introduces Pain-free Fat Removal Technique 3Health News:New BuildClean™ System Brings Livability Back to Home Remodeling 2Health News:New BuildClean™ System Brings Livability Back to Home Remodeling 3Health News:New BuildClean™ System Brings Livability Back to Home Remodeling 4Health News:PTSD Link to Food Addiction Seen in Report 2Health News:PTSD Link to Food Addiction Seen in Report 3Health News:DiabetesSisters Showcases Radio Talk Show Host Mother Love at Weekend for Women Conference in Los Angeles 2Health News:Diet Doc Discloses the Results of a Recent In-House Survey Revealing an Average Loss of 20 Pounds Per Month with Their No Carb Diet Plans 2Health News:Diet Doc Discloses the Results of a Recent In-House Survey Revealing an Average Loss of 20 Pounds Per Month with Their No Carb Diet Plans 3
... who received Medicare coverage reported improvements in health, ... to a study in the December 26 issue ... those with cardiovascular disease or diabetes, experience worse ... Medicare beneficiaries after age 65 years than insured ...
... for youngsters can reduce risk of shoulder injury, physician ... Playing catch with your young pitcher months before baseball season ... rotator cuff injuries, according to doctors at Methodist Hospital in ... high pitch count and throwing curve balls -- increases the ...
... taking things as they come, expert says , MONDAY, Dec. ... and social stress, and memories of lost loved ones can ... lead to seasonal blues during the holidays, says an expert ... expect difficult relationships to improve just because it,s Christmas are ...
... weeks to a better body &,better health begins on January ... this amazing challenge begins on January 5th at,the ,New Vision ... life changing challenge is simple; it includes a $25,enrollment fee, ... looks at the health of the cells in the body ...
... Introduces Plan to Use Funding Surplus to Provide ... HARRISBURG, Pa., Dec. 24 Governor Edward G.,Rendell ... billing, but to postpone collection until March 31. ... coverage that the state,s,physicians, and many other health ...
... 24 /Xinhua-PRNewswire/ -- Chindex International,Inc. (Nasdaq: CHDX ... and products in the People,s Republic of China, ... the listing of its common stock on,the NASDAQ ... NASDAQ Capital,Market to the NASDAQ Global Market has ...
Cached Medicine News:Health News:Health improves for previously uninsured adults after receiving Medicare coverage 2Health News:Playing Catch in Winter Could Save Kids' Pitching Arms 2Health News:Realistic Expectations Help Ward Off Holiday Depression 2Health News:10 Weeks to a Better Body & Better Health With Dr. Ramsey's Health Challenge 2Health News:Governor Rendell Directs Insurance Commissioner to Delay Mcare Abatement Collection 2Health News:Governor Rendell Directs Insurance Commissioner to Delay Mcare Abatement Collection 3Health News:Governor Rendell Directs Insurance Commissioner to Delay Mcare Abatement Collection 4Health News:Governor Rendell Directs Insurance Commissioner to Delay Mcare Abatement Collection 5Health News:Chindex International, Inc. Announces Transfer to NASDAQ Global Market 2Health News:Chindex International, Inc. Announces Transfer to NASDAQ Global Market 3
(Date:9/18/2014)... 18, 2014  Spring Bank Pharmaceuticals, Inc., a ... treatment of RNA viruses, today announced a research ... for animal testing of the Company,s lead compound, ... "Special Pathogens," against which currently there are no ... Spring Bank,s proprietary Small Molecule Nucleic Acid ...
(Date:9/18/2014)... , Sept. 18, 2014  RXi ... a biotechnology company focused on discovering, developing ... medical needs using RNA-targeted technologies, today announced that ... Dr. Geert Cauwenbergh , will present ... America™ Conference on Wednesday, September 24, 2014 ...
(Date:9/17/2014)... -- DeepResearchReports.com adds "2014 Market Research Report on ... Research Report on Global and China Isothiocyanate Industry" ... Photo - http://photos.prnewswire.com/prnh/20140917/146748 ... (MMA) Industry" is a professional and in-depth research ... Global Methyl Methacrylate (MMA) market. The report introduces ...
Breaking Medicine Technology:Spring Bank Pharmaceuticals Announces NIH Collaboration for Testing of SB 9200 Against Multiple Viral Pathogens 2RXi Pharmaceuticals to Present at the 7th Annual BioPharm America Conference 2RXi Pharmaceuticals to Present at the 7th Annual BioPharm America Conference 3Methyl Methacrylate Market & Chinese Isothiocyanate Industry Trend Development 2Methyl Methacrylate Market & Chinese Isothiocyanate Industry Trend Development 3Methyl Methacrylate Market & Chinese Isothiocyanate Industry Trend Development 4Methyl Methacrylate Market & Chinese Isothiocyanate Industry Trend Development 5
... Spencer Inc. (NYSE: CSA ) announced today ... of $0.10 per common share payable on October 20, 2010 ... covers the third quarter of 2010.   ... Spencer Inc. (NYSE: CSA ) is a fully-integrated, ...
... Pharmaceutical Company (NYSE:  KVa/KVb) announced today that it has ... ("FDA") of the successful completion of an inspection of ... product to market.  Under the Company,s Consent Decree, successful ... facilities are expected to be required before K-V is ...
Cached Medicine Technology:Cogdell Spencer Inc. Declares Quarterly Dividend 2K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 2K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 3K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 4K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 5K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 6K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 7K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 8
Hardy pituitary spoon, bayonet, malleable....
Cushing pituitary spoons, malleable copper, silver plated....
... is pouncing on the T.L.I.F. market as the ... of CFRP clinical history and the amazing success ... Leopard is sure to be king of the ... from 7-18 mm in height. The footprint is ...
... an Anterior Spinal Implant system. Material that ... of cortical bone. The result is an ... anterior column support, while optimizing the fusion ... Incorporates an anatomic design with 5 and ...
Medicine Products: