Navigation Links
Novel method to reveal drug targets
Date:2/22/2008

Wellcome Trust Sanger Institute scientists have developed a new large-scale method to identify the interactions between proteins that are a major target for therapeutic intervention. The novel method can identify the weak, short-lived interactions that are characteristic of cell responses to cues from the environment or from within the body.

Cell surface proteins are targets for many drugs and are central to many processes of cell regulation, such as some cancer therapeutics, diabetes, and growth. The team hope the method will uncover many important interactions that are invisible to current detection methods.

Many proteins act as molecular switches, responding to signals and activating specific genes or specific cell processes. Using biochemical tricks to increase the chances of detecting the transient and weak, but potentially important, interactions, the scientists describe 17 new pairs of interactions in mammalian cells.

"If a genome is the code for life, interactions between proteins are the communications system - the internet of our bodies," Explains Dr Gavin Wright, Junior Investigator at the Wellcome Trust Sanger Institute. "The challenge we face is that current methods cannot efficiently detect interactions at the place where communication starts: the cell surface, nor can they reliably detect transient weak interactions.

"Our new method transforms the large-scale search for these important interactions."

Unlike DNA sequencing, where methods are common to all organisms, there has been no one approach that gives a global fit for all diverse protein-protein interactions. The new method, called AVEXIS, should be applicable to interactions at the cell surface in many organisms.

Drug targets are often proteins at the surface of the cell since they are easily accessible to drugs in contrast to proteins within our cells. Unfortunately, the current catalogue of known protein interactions is biased away
'/>"/>

Contact: Don Powell
don@sanger.ac.uk
44-012-234-96928
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
2. Novel virus detection identifies new viruses in study of respiratory infections and asthma attacks
3. Researchers uncover novel mechanism that balances the sizes of functional areas in the brain
4. Novel Cooling Therapy May Have Aided Injured Football Player
5. ECLIPSE data on effects of Otsukas investigational novel treatment, Tolvaptan
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. GrantAdler Shipping Novel Implantable Vascular Access Port
8. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
9. Novel strategy under study for aggressive leukemia
10. ISTO Technologies Receives 510(k) Clearance for a Novel Bone Graft Substitute and Bone Graft Extender
11. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... Yisrayl Hawkins, Pastor at The House of Yahweh in ... the Ferguson, Missouri unrest. Yisrayl starts his letter by showing ... it has only increased. , He continues in his ... there is a very specific reason for mankind and covers ... set of rules, or Laws that if followed would ensure ...
(Date:12/26/2014)... Viejo, California (PRWEB) December 26, 2014 Plugin ... announced the TransPack Volume 5 Plugin for Final Cut Pro ... manipulate a hard light tool to pull off an industry ... “When users get their hands on TransPack Volume 5, a ... Volume 5 is a set of over 50 Final Cut ...
(Date:12/26/2014)... FL (PRWEB) December 26, 2014 India ... health insurance in the USA, announced today a new ... assist members in choosing the right plan for their ... the complexity out of the selection process when choosing ... by age group with only a few clicks. Many ...
(Date:12/26/2014)... December 26, 2014 DW-InductionHeating.com (DaWei Induction ... designing, researching and developing, producing and marketing of a ... the business announces their new series of induction ... of the company, induction brazing refers to ... special filler material and heat. The manager says that ...
(Date:12/25/2014)... 2014 The microscopy market is ... to reach $5,756.0 million by 2019. Optical microscopy ... The electron microscopes product segment is expected to ... , Rising focus on nanotechnology, technological advancements, and ... microscopy market. , Get Full Copy of Report ...
Breaking Medicine News(10 mins):Health News:Yisrayl Hawkins Pleads for Peace in Ferguson and Beyond in New Open Letter 2Health News:Today a new plugin was announced from Pixel Film Studios, TransPack Volume 5 for Final Cut Pro X 2Health News:India Network Health Insurance Announces new Comprehensive Pre-existing Condition Coverage policy for Visitors to the United States 2Health News:India Network Health Insurance Announces new Comprehensive Pre-existing Condition Coverage policy for Visitors to the United States 3Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 3Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 4
... program focused on cervical cancer prevention thanks to ... Indiana University School of Medicine, in partnership with ... Cancer-Free America (CCFA) is an initiative designed to ... increase rates of human papillomavirus (HPV) vaccination with ...
... imaging plays an important role in biological and ... advanced technology and expertise, and can be costly. ... today, aims to provide scientists throughout Europe with ... levels of biological and biomedical research, from bench ...
... Harvard-affiliated McLean Hospital and the University of Utah have ... date. The test was able to detect the disorder ... The study will be published online the week of ... which uses MRI to measure deviations in brain circuitry, ...
... Dec. 1 (HealthDay News) - A physician with experience ... "Don,t Ask, Don,t Tell" policy puts both service members ... about sexual health issues. "Infections go undiagnosed. Service ... a physician at San Diego State University and the ...
... nearly three times as likely as civilians to commit ... Portland State University (PSU) and Oregon Health & Science ... Women With U.S. Military Service: A Hidden Epidemic?" appears ... , a journal published by the American Psychiatric Association. ...
... (HealthDay News) -- Deployment to Iraq and Afghanistan significantly ... U.S. military personnel, new research indicates. Researchers conducted ... military before they deployed to these conflict zones. The ... the journal Sleep . "This is the ...
Cached Medicine News:Health News:Grant launches cervical cancer-free Indiana initiative 2Health News:Better imaging from bench to bedside 2Health News:University of Utah and Harvard researchers take major step toward first biological test for autism 2Health News:'Don't Ask, Don't Tell' May Put Soldiers' Health at Risk, Doctor Says 2Health News:Suicide rate among young women veterans more than twice that of civilians 2Health News:Military Deployment May Lead to Unhealthy Sleep Patterns 2
(Date:12/24/2014)... BUFFALO, N.Y. , Dec. 24, 2014 ... been dosed with KX2-361 at Roswell Park Cancer Institute. ... a small molecule drug that has shown potent inhibitory ... lines, including those that are resistant to Temozolomide (T98G), ... malignant glioma. In a well-established brain tumor mouse model, ...
(Date:12/24/2014)... , Dec. 24, 2014  The International Trade Commission (ITC) ... (RMD) against BMC Medical. In a notice issued on December ... that ResMed,s patent on its humidifier was invalid. ... "monumental win". "We are very excited with the ITC,s decision ... that we have taken since the very beginning on the ...
(Date:12/24/2014)... Dec. 24, 2014  Diplomat Pharmacy, Inc. (NYSE: ... is proud to announce Jennifer Hagerman , Pharm.D., ... will take office as the president of the Michigan ... ceremony will take place Feb. 28, 2015, at the ... at the Renaissance Center in Detroit, Michigan ...
Breaking Medicine Technology:Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 2Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 3ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3
... the leaders of "America,s pastime," a free open-source screen-reading software ... of Camp Abilities have in common? All have taken successful ... who are blind or visually impaired, which is why they ... today by the American Foundation for the Blind (AFB). ...
... Pharmaceutical Inc., a biotechnology company focused on developing ... announced that the European Medicines Agency (EMA) has ... the treatment of hereditary inclusion body myopathy (HIBM) ... mucopolysaccharidosis type 7 (MPS 7).  Orphan designation in ...
Cached Medicine Technology:American Foundation for the Blind Announces 2012 Access Award Winners 2American Foundation for the Blind Announces 2012 Access Award Winners 3Ultragenyx Granted Orphan Designations in Europe for Two Lead Product Candidates, UX001 for HIBM and UX003 for MPS 7 2Ultragenyx Granted Orphan Designations in Europe for Two Lead Product Candidates, UX001 for HIBM and UX003 for MPS 7 3
... Store 200 to 350 Liters of pure ... and Distribution of Purified Water,Millipores compact S.D.S. ... store 200 to 350 liters of purified ... and to maintain consistent purity of stored ...
... to 350 Liters of pure water, Complete, ... of Purified Water,Millipores compact S.D.S. Storage and ... to 350 liters of purified water produced ... maintain consistent purity of stored water, provide ...
... Liters of pure water, Complete, Compact Systems ... Water,Millipores compact S.D.S. Storage and Distribution Systems ... liters of purified water produced by Elix ... purity of stored water, provide effective protection ...
... Store 200 to 350 Liters of pure ... and Distribution of Purified Water,Millipores compact S.D.S. ... store 200 to 350 liters of purified ... and to maintain consistent purity of stored ...
Medicine Products: