Navigation Links
Novel mechanisms controlling insulin release and fat deposition discovered
Date:5/13/2008

[PRESS RELEASE, 13 May 200] Scientists at the Swedish medical university Karolinska Institutet have in two recent studies shown that a receptor called ALK7 plays important roles in the regulation of body fat deposition as well as the release of insulin from beta-cells in the pancreas. These findings have implications for the development of treatments against diabetes and obesity.

We have shown in animal studies that removing the ALK7 receptor improves insulin release by beta-cells in the pancreas, and at the same time decreases fat deposition in situations of high caloric intake, says Professor Carlos Ibez, who lead the two studies that are now published as back-to-back papers in the PNAS. The well-known connections between diabetes and obesity make our combined findings quite exciting.

Up to 6 per cent of the world population is estimated to suffer from some form of diabetes, either due to a reduced ability to produce insulin, or to insulin resistance. Insulin is a hormone required by cells in the body to absorb glucose from the blood, thereby providing them with energy. Obesity has been shown to increase the risk of developing diabetes, and as overweight becomes more prevalent in the human population, so do the cases of diabetes.

The research group led by Carlos Ibez studies how signaling by growth factors and their receptors regulate different physiological functions in the body. They have recently investigated the functions of one of these receptors, called ALK7, using mutant mice (knock-out mice) lacking this receptor. They found that in the absence of ALK7, mice developed abnormally high levels of insulin in the blood, which with age led to insulin resistance and liver steatosis, a pathological condition in which the liver enlarges and accumulates abnormally high levels of fat.

In collaboration with another research group at Karolinska Institutet, led by Professor Per-Olof Berggren, they also found that Calcium sig
'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Preliminary Results from Phase 2 Genzyme Study Highlight Potential of Novel Oral Compound for Gaucher Disease
2. Discovery of a novel mechanism for the development of colon cancer
3. TorreyPines Therapeutics Licenses Intellectual Property from Johns Hopkins Related to Novel Uses of Glutamate Receptor Antagonists for Prevention, Treatment of Stroke, Heart Attack
4. Latona Announces the Acquistion of Patent Rights and Orphan Drug Status to Novel Late Stage Drug Compound for Juvenile and Adult Rheumatoid Arthritis
5. Scientists identify novel way to prevent cardiac fibrosis
6. Registry unveils real-world data on novel excel stent
7. Researchers sharpen search for new marine medicines with novel techniques
8. Increased hepcidin expression: A novel oncogenic signalling mechanism
9. Novel discovery by Einstein scientists could lead to much-needed kidney failure treatment
10. Scripps Florida awarded $7.6 million grant to develop novel treatment for Parkinsons disease
11. Affinium Pharmaceuticals, Ltd. Announces Initiation of a Phase I Clinical Trial for AFN-1252, its Novel Anti-staphylococcal Antibiotic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... ... ... Sculpted Contours Luxury Medical Aesthetics proudly announces that Kathy King, Owner/Managing Director was ... Atlantan Magazine. , This award for the Sculpted Contours Founder is a ... vision to bring to Atlanta a true luxury experience in a medical aesthetic center ...
(Date:8/31/2015)... ... August 31, 2015 , ... Southern Vacation Rentals – ... teamed up with fellow South Walton property management company, 360 Blue, in ... in remote parts of the world. The two companies will collect any unopened food ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... registration for the company’s second Introduction to Hyperbaric Medicine Course. The next UHMS ... aboard the Queen Mary Hotel in Long Beach, CA. The meeting is open ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... classes. , Starting September 1st they are offering pre and postnatal ... and "Healthy Body, Healthy Baby." , More information can be found at 248-601-6683. ...
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... The ... healthcare to Veterans residing across southwest Florida by hiring more doctors and nurses and ... list of expanded services. , In early July, Dr. Anthony Jabre was selected to ...
Breaking Medicine News(10 mins):Health News:Sculpted Contours Owner Selected One of Atlanta's Women of Power and Influence by Modern Luxury's The Atlantan Magazine 2Health News:Sculpted Contours Owner Selected One of Atlanta's Women of Power and Influence by Modern Luxury's The Atlantan Magazine 3Health News:Southern Vacation Rentals Partners with the Sonder Project 2Health News:Southern Vacation Rentals Partners with the Sonder Project 3Health News:Registration Opens for Wound Care Advantage’s Second UHMS Approved 40-Hour Introduction to Hyperbaric Medicine Course 2Health News:Registration Opens for Wound Care Advantage’s Second UHMS Approved 40-Hour Introduction to Hyperbaric Medicine Course 3Health News:Registration Opens for Wound Care Advantage’s Second UHMS Approved 40-Hour Introduction to Hyperbaric Medicine Course 4Health News:Neurosurgeon Selected to Lead Growing Spine Care Program 2Health News:Neurosurgeon Selected to Lead Growing Spine Care Program 3
... that nearly 55 percent of Americans, mostly women, are ... and brittle bones// that causes higher susceptibility to bone ... found to contribute to lower bone mineral density in ... PhD, director of the Epidemiology and Dietary Assessment Program ...
... ENBRELR (etanercept) safe to be used to treat psoriasis up ... result of the current studies were presented at the 15th ... a 'Biologic Medicine which means it is synthesized using recombinant ... of biotechnology. , , ,This biologic medicine acts ...
... for their future good health, says a new study//.John Reilly ... nurseries in Glasgow. ,The researchers monitored the children ... minutes, three times a week, reported the online edition of ... to affect the children's body mass index (BMI), the researchers ...
... The mosquito-borne dengue disease continued to take its toll across ... 3,000 suffering// from it even as the government maintained the ... Anbumani Ramadoss said: "The situation is not that of an ... will see a decreasing trend in the next two-three days. ...
... their cholesterol levels down for decades, ever since studies showed ... in recent years, experts have suggested that some people should ... type of cholesterol called low-density lipoprotein for some high-risk people ... medications to get there. ,Not so fast, says a ...
... stumbled upon some very interesting results following her study ... genetic characteristics of alcoholics, which ultimately determine which drugs ... drink. ,The urge to consume alcoholic drinks can ... investigations done by the researcher highlights which characteristics of ...
Cached Medicine News:Health News:Consumption of Colas Increase Risk of Osteoporosis in Older Women 2Health News:Consumption of Colas Increase Risk of Osteoporosis in Older Women 3Health News:Enbrelr Enters Safer Zone After Recent Research 2Health News:India registers 3,000 dengue patients, toll crosses 40 2Health News:India registers 3,000 dengue patients, toll crosses 40 3Health News:India registers 3,000 dengue patients, toll crosses 40 4Health News:No Clear Evidence for Ultra-Low Cholesterol Targets? 2Health News:No Clear Evidence for Ultra-Low Cholesterol Targets? 3Health News:No Clear Evidence for Ultra-Low Cholesterol Targets? 4
(Date:8/31/2015)... -- Thousands of people will peacefully demonstrate their frustration ... epidemic at dozens of rallies across the country today. ... the United States has experienced skyrocketing rates ... heroin, yet the President has never once spoken publicly ... to President Obama , rally organizers compared his failure ...
(Date:8/31/2015)... Calif. , Aug. 31, 2015 ... flow cytometry is experiencing a rise in active ... demand in underdeveloped nations to quantitate CD4 cell ... Logo - http://photos.prnewswire.com/prnh/20150831/262206LOGO ... of the Global Flow Cytometry Market ( http://www.frost.com/nf0e ...
(Date:8/31/2015)... , Aug. 31, 2015 The Wolf ... statewide since Pennsylvania State Police ... drug kits, naloxone. Heroin and opioid overdose ... Pennsylvania , killing more individuals than those ... 2,400 Pennsylvanians died from a drug overdose. ...
Breaking Medicine Technology:Obama Administration's Neglect of Opioid Crisis Prompts Rallies in Many States 2Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 2Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 3Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 4Departments of Drug & Alcohol Programs and Health Announce Report 289 Pennsylvanian Lives Saved by Naloxone 2Departments of Drug & Alcohol Programs and Health Announce Report 289 Pennsylvanian Lives Saved by Naloxone 3
... WASHINGTON, Sept. 8, 2011 ... in global bribery trends and risk mitigation strategies have ... them with today,s launch of the new TRACE website. ... site offers an array of valuable and practical resources ...
... 8, 2011 As the country,s economic recovery continues ... new research from the National Association of Chain ... drugstores have opened in the last two years while ... "This new drugstore research runs counter to ...
Cached Medicine Technology:TRACE Launches Enhanced Anti-Bribery Compliance Website 2
... The Sound Pro Combination ... table solution, combining the ... the Ultra Pro and ... ideal for OB/GYN, general ...
...
... primers and a FAM-labeled probe that is designed ... mecA gene. In addition, this ASR contains primers, ... internal control sequence. This ASR requires an instrument ... dyes such as the Cepheid SmartCycler System. The ...
... Device features the ability to use a ... and a pre-loaded nitinol filter with a ... a fully rapid exchange system, the SpideRX ... indicated applications:, Carotid Indication - ,The SpideRX ...
Medicine Products: