Navigation Links
Novel imaging technique shows gray matter increase in brains of autistic children

CHICAGO Using a novel imaging technique to study autistic children, researchers have found increased gray matter in the brain areas that govern social processing and learning by observation. Results of the study conducted at the Fay J. Lindner Center for Autism, North Shore-Long Island Jewish Health System in Bethpage, N.Y., were presented today at the annual meeting of the Radiological Society of North America (RSNA).

Our findings suggest that the inability of autistic children to relate to people and life situations in an ordinary way may be the result of an abnormally functioning mirror neuron system, said lead author Manzar Ashtari, Ph.D., from the Childrens Hospital of Philadelphia in Pennsylvania.

Mirror neurons are brain cells that are active both when an individual is performing an action and experiencing an emotion or sensation, and when that individual witnesses the same actions, emotions and sensations in others. First observed in the macaque monkey, researchers have found evidence of a similar system in humans that facilitates such functions as learning by seeing as well as doing, along with empathizing and understanding the intentions of others. Dr. Ashtaris study found the autistic children had increased gray matter in brain regions of the parietal lobes implicated in the mirror neuron system.

The study included 13 male patients diagnosed with high-functioning autism or Asperger syndrome and an IQ greater than 70 and 12 healthy control adolescents. Average age of the participants was about 11 years. Each of the patients underwent diffusion tensor imaging (DTI), a technique that tracks the movement of water molecules in the brain.

DTI is traditionally used to study the brains white matter, as well as the brain fibers. However, Dr. Ashtaris team applied it to the assessment of gray matter by employing apparent diffusion coefficient based morphometry (ABM), a new method that highlights brain regions with potential gray matter volume changes. By adding ABM to DTI, the researchers can detect subtle regional or localized changes in the gray matter.

In addition to the gray matter abnormalities linked to the mirror neuron system, the results of this study revealed that the amount of gray matter in the left parietal area correlated with higher IQs in the control group, but not in the autistic children.

In the normal brain, larger amounts of gray matter are associated with higher IQs, Dr. Ashtari said. But in the autistic brain, increased gray matter does not correspond to IQ, because this gray matter is not functioning properly.

The autistic children also evidenced a significant decrease of gray matter in the right amygdala region that correlated with severity of social impairment. Children with lower gray matter volumes in this area of the brain had lower scores on reciprocity and social interaction measures.

Impairments in these areas are the hallmark of autism spectrum disorders, and this finding may lead to greater understanding of the neurobiological underpinnings of the core features of autism, said study co-author Joel Bregman, M.D., medical director of the Fay J. Lindner Center for Autism.

Autism is the fastest growing developmental disability in the United States and typically appears during the first three years of life. Children with autism are hindered in the areas of social interaction and communication skills. According to the Centers for Disease Control and Prevention, as many as 1.5 million Americans have autism.


Contact: Linda Brooks
Radiological Society of North America

Related medicine news :

1. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
2. Novel Cooling Therapy May Have Aided Injured Football Player
3. Novel virus detection identifies new viruses in study of respiratory infections and asthma attacks
4. Researchers uncover novel mechanism that balances the sizes of functional areas in the brain
5. ECLIPSE data on effects of Otsukas investigational novel treatment, Tolvaptan
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. GrantAdler Shipping Novel Implantable Vascular Access Port
8. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
9. Novel strategy under study for aggressive leukemia
10. ISTO Technologies Receives 510(k) Clearance for a Novel Bone Graft Substitute and Bone Graft Extender
11. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... Dr. Poneh Ghasri, ... Today on September 18, 2015. The research, which was conducted at the Dental Institute ... and colleagues, show connections between stress during pregnancy and future dental health in the ...
(Date:10/13/2015)... ... October 13, 2015 , ... Leading Internet marketing ... launched "Publish Academy" training course . Singal's new program, in which he ... and marketers around the Internet are weighing in with reviews. , "Considering the ...
(Date:10/13/2015)... ... , ... Scientists in Seattle and Vancouver compared the diagnostic value of lung ... Surviving Mesothelioma has just posted an article on the new research. Click here ... the University of British Columbia found that certain genetic alterations were seen just as ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... School of Nursing. Dr. McLeod—who earned her Doctor of Nursing Practice from the ... that has spanned four decades. , Dr. McLeod’s long and successful nursing practice ...
(Date:10/13/2015)... ... 13, 2015 , ... Breathing is one of the human ... According to T’ai Chi (also spelled “Taiji”) and Qigong Grand-masters Steven Aung, MD, ... with the 7,000 year old tradition they teach, can improve health, increase energy ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... Oct. 13, 2015   Rosa & Co. LLC ... Quantitative Systems Pharmacology (QSP)/ PhysioPD™ , today announced that ... a workshop at the QSP Congress Meeting ... Boston, MA.  The conference focuses on the ...  Dr. Friedrich,s workshop is entitled "Using Mechanistic Physiological Models ...
(Date:10/13/2015)... , Oct. 13, 2015 China ... or " China Jo-Jo "), a leading China-based retail, ... products through its own online and retail pharmacies, announced ... Company,s official branded online pharmacy through , ... was a record 25%. China Jo-Jo,s ...
(Date:10/13/2015)... 13, 2015  Yesterday Congresswoman Renee Ellmers ... manufacturing site located in Holly Springs, NC ... produced Flucelvax ® (Influenza Vaccine) using cell-culture technology, a ... start-up and is not reliant on chicken eggs. 1,2 ... influenza vaccines business of Novartis AG in the US, ...
Breaking Medicine Technology: