Navigation Links
Novel herbal compound offers potential to prevent and treat Alzheimer's disease
Date:2/15/2013

into similar control and TSG-treated groups and were treated for 6 months.

The authors used a variety of techniques to hone in on what was happening in the brains of the Tg mice compared to age-matched controls: cDNA microarray analysis, reverse transcription PCR, western blotting, and immunochemistry. They found that α-synuclein messenger RNA (mRNA) and protein expression levels increase in a time-dependent manner in the hippocampus of Tg mice between ages 4 and 16 months and α-synuclein aggregation was noticeable at 16 months. Age-related increases in α-synuclein were also seen in the control mice but to a lesser degree.

"We suggest that, besides increased Aβ (beta-amyloid) and amyloid plaques, overexpression and aggregation of α-synuclein in the hippocampus might partially account for cognitive impairment in this Tg mouse model of AD," comments co-lead investigator Lin Li, MD, PhD, Professor and Director, Department of Pharmacology, Xuanwu Hospital of Capital Medical University in Beijing. She adds that "α-synuclein overexpression occurs even in the early phase of AD and may accelerate Aβ production and deposition, which further facilitates α-synuclein overexpression and accumulation."

Analysis of the TSG-treated groups showed that TSG-treatment from the age of 4 to 10 months significantly downregulated α-synuclein mRNA and protein overexpression in the hippocampus of the Tg mice, and the effect was stronger at the higher dose. This suggests that TSG may have a role in preventing the neurotoxic effects of α-synuclein on synaptic function and cell activity. In addition, the finding that Tg reduced α-synuclein overexpression in older animals (>10 months) may indicate that it has therapeutic potential even after neuropathologic changes have occurred.

In previous work, the authors found that TSG acts as a "cognitive enhancer" to improve learning and memory in both APP transg
'/>"/>

Contact: Daphne Watrin
d.watrin@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment
2. Rutgers team discovers novel approach to stimulate immune cells
3. Novel drug candidates offer new route to controlling inflammation
4. Researchers present new findings for novel pancreatic cancer vaccine
5. Novel biomarkers reveal evidence of radiation exposure
6. VCU Massey Cancer Center sees potential in novel leukemia treatment
7. Study supports urate protection against Parkinsons disease, hints at novel mechanism
8. Novel Natural Sciences Repository Opens Web Portal
9. Novel Anti-Inflammatories May Offer a New Approach for the Treatment of Stroke
10. LA BioMed investigators, Drs. Kevin Bruhn and Noah Craft, develop novel treatment for melanoma
11. Novel radiation therapy safely treats prostate cancer and lowers the risk of recurrence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2015)... Houston, Texas (PRWEB) April 19, 2015 ... is pleased to announce the publication of white paper ... Online Affair . As online media provides a ... whole new niche market specifically targeting adulterous spouses ... which an affair becomes as easy as shopping online. ...
(Date:4/18/2015)... April 19, 2015 The Residential ... during the past five years. The industry, which provides ... unable to fully care for themselves, has boomed on ... for dementia care for seniors with memory impairment. As ... an annualized rate of 4.1% to $1.9 billion over ...
(Date:4/18/2015)... PA (PRWEB) April 18, 2015 "I ... evacuation stretchers in healthcare facilities," said an inventor from ... alternative storage system." , He developed the Slyde Door ... doors used in healthcare facilities. It provides convenient storage ... there are more stretchers available for patients. , ...
(Date:4/18/2015)... 2015 Lower-auto-insurance.com has released a new ... auto insurance quotes . , Drivers can find ... quotes. A professional insurance brokerage website can help drivers ... a simple, convenient way. The whole process is designed ... , Comparing online car insurance quotes is advantageous because ...
(Date:4/18/2015)... On April 14th, 2015, Symantec released ... they say, “exposes a tactical shift by cyberattackers.” With everything ... introduced in 2014 - almost a million a day - ... be identified and patched by prominent manufacturers – as long ... business in a digital world can be fraught with peril, ...
Breaking Medicine News(10 mins):Health News:McCann Investigations Publishes White Paper Married, but Dating: The Rise of the Married Online Affair 2Health News:Residential Senior Care Franchises in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Residential Senior Care Franchises in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Auto Insurance Quotes Can Provide Accurate Results! 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 3Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 4Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 5
... prevention office of the Ministry of Health released a data ... which//, around 45,000 new cases of eyesight loss are reported ... reported 12 million people handicapped with eye problems, including about ... director with the blindness prevention office in East China's Shandong ...
... sickness or Human African trypanosomiasis is caused by the bite ... passes on the parasite called the trypanosome, to human beings ... disease over the past two decades in Sub-Saharan Africa. The ... of the number of people suffering this sickness, which is ...
... for protection of traditional medicines that they say is ... practitioners. ,Mei Zhinan, an expert in traditional ... said 80 percent of China's 55 minority groups, accounting ... billion population, had their own traditional medicines and secret ...
... accredited NewYork-Presbyterian Hospital as a Bariatric Surgery Center Network ... recognition of the Hospital's ability to offer patients the ... for New York state and one of only seven ... 20 years of age and older are obese -- ...
... by S. Kankova and colleagues from the Departments of ... Reproductive Medicine; and GynCentrum, in the Czech Republic, women ... than women who are Toxoplasma negative. // ... in human with a universal occurrence of 20-80%. This ...
... role in longevity, with longer-lived rodents showing significantly lower ... new study has found.// ,The study further strengthens ... shorter its life, and vice versa, said Mario Pinto, ... regulate metabolic rate. ,“Thyroid hormones are key ...
Cached Medicine News:Health News:Understanding Sleeping Sickness 2Health News:Understanding Sleeping Sickness 3Health News:Chinese Experts Call for Protection of Traditional Medicines 2Health News:NewYork-Presbyterian Receives Highest Accreditation for Bariatric Surgery 2Health News:Effect of parasitic infection on baby's sex 2Health News:Longer-Lived Rodents Have Lower Levels of Thyroid Hormone 2
(Date:4/17/2015)... - The issue: In consultation ... lot (lot 710535) of Clavulin-400 (70mL) after receiving a complaint ... in one bottle of the  product. No other lots of ... Clavulin-400 is an oral antibiotic used in adults and children ... Clavulin-400 comes as a powder in bottles and is mixed ...
(Date:4/17/2015)... N.C. , April 17, 2015 ... the Integrated Embolic Protection™ filter platform for angioplasty ... of a $5.6 million Series B financing round ... venture firm with a focus on medical devices, ... The round also included Mountain Group Partners, Lookout ...
(Date:4/17/2015)... , April 17, 2015  Regulatory leaders in the ... bipartisan discussion draft called "21 st Century Cures." ... to be taken up by Congress soon and if ... medical device products are developed and marketed in ... many companies have begun to consider how the proposed ...
Breaking Medicine Technology:Advisory - Clavulin-400 liquid oral antibiotic: One lot recalled after glass pieces found in one bottle 2Contego Medical Closes $5.6 Million in Series B Funding 2Contego Medical Closes $5.6 Million in Series B Funding 321st Century Cures: A Regulatory Game-Changer for the Pharmaceutical Industry 2
... able to save part of each kidney in ... tumors appear on preoperative,scans, MEMPHIS, Tenn., March ... demonstrated that children with bilateral,Wilms tumor, a cancer ... both,kidneys by undergoing a procedure called bilateral nephron-sparing ...
... Pre-existing Lamivudine Resistance Predisposes Patients to ... Higher Rates of BARACLUDE Resistance ... data presented today demonstrated a continued low incidence of,resistance ... nucleoside-naive chronic hepatitis B patients analyzed, no additional,patient developed ...
Cached Medicine Technology:St. Jude Study Offers New Hope for Children With Kidney Tumors Deemed Inoperable 2BARACLUDE(R) (entecavir) Data Continue to Demonstrate Low Incidence of Resistance Through Five Years of Treatment in Nucleoside-naive Chronic Hepatitis B Patients 2BARACLUDE(R) (entecavir) Data Continue to Demonstrate Low Incidence of Resistance Through Five Years of Treatment in Nucleoside-naive Chronic Hepatitis B Patients 3BARACLUDE(R) (entecavir) Data Continue to Demonstrate Low Incidence of Resistance Through Five Years of Treatment in Nucleoside-naive Chronic Hepatitis B Patients 4BARACLUDE(R) (entecavir) Data Continue to Demonstrate Low Incidence of Resistance Through Five Years of Treatment in Nucleoside-naive Chronic Hepatitis B Patients 5BARACLUDE(R) (entecavir) Data Continue to Demonstrate Low Incidence of Resistance Through Five Years of Treatment in Nucleoside-naive Chronic Hepatitis B Patients 6
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: