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Novel herbal compound offers potential to prevent and treat Alzheimer's disease
Date:2/15/2013

Amsterdam, NL, February 15, 2013 Administration of the active compound tetrahydroxystilbene glucoside (TSG) derived from the Chinese herbal medicine Polygonum multiflorum Thunb, reversed both overexpression of α-synuclein, a small protein found in the brain, and its accumulation using a mouse model of Alzheimer's disease. These results, which may shed light on the neuropathology of AD and open up new avenues of treatment, are available in the current issue of Restorative Neurology and Neuroscience.

Aberrant accumulation of α-synuclein can form insoluble aggregates that have been implicated in several neurodegenerative diseases, including Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease (AD). Researchers have now found that overexpression of α-synuclein increases with age and have demonstrated that α-synuclein aggregates in the hippocampus of older mice compared to normal controls.

"Our results raise the possibility that TSG might be a novel compound for the treatment of AD and dementia with Lewy body," says co-lead investigator Lan Zhang, MD, PhD, Associate Professor, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Department of Pharmacology of Xuanwu Hospital of Capital Medical University in Beijing.

The study used an animal model of AD: APPV717I transgenic (Tg) mice with the London mutation. In previous work, the authors showed that these mice show cognitive impairments beginning at 4 months of age and develop amyloid plaques in the brain that are evident by 10 months.

In one series of experiments, 4 month old Tg mice were divided into 3 groups and received daily intragastric administration of distilled water (controls), low dose TSG (120 mol/kg/d), or high dose TSG (240 mol/kg/d). A fourth group consisted of age-matched non-Tg controls. The mice were treated until 10 months of age. In a second series of experiments, 10-month-old mice were divided
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Contact: Daphne Watrin
d.watrin@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

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