Navigation Links
Novel gene predicts local recurrence in early onset breast cancer
Date:5/6/2009

recurrence up to 12 years after surgery," Killary said. Of the 123 early-onset patients, 72 percent had no lymph node involvement at diagnosis.

Low expression associated with triple-negative breast cancer

While the researchers found that loss of DEAR1 expression correlated significantly with local recurrence, it did not correlate with overall survival in this young cohort.

However, lack of DEAR1 expression was associated with triple-negative breast cancer, which indicates poor prognosis because it lacks estrogen or progesterone receptors and does not express HER2, three targets for therapy. Lack of DEAR1 expression also was associated with a strong family history of breast cancer.

The team discovered the gene in a region of the human genome that has been implicated in other epithelial tumors, including colon and pancreatic cancers, and that the researchers suspected might harbor an important tumor suppressor gene. Finding that DEAR1 was mutated in breast cancer suggested that it could play a role in the initiation and progression of the disease.

The researchers found evidence that DEAR1 plays a critical regulatory role in acinar morphogenesis, or the orderly development and differentiation of the terminal ductal lobular units (TDLU) in the breast. TDLUs are structures present at the ends of a branching network of ducts in the normal mammary gland which also are thought to be the site of origin of many breast cancers. Mutations in DEAR1 lead to cellular disorganization, lack of cell differentiation, and loss of normal structure in breast tissue - all hallmarks of a transition to malignancy.

Mutated or deleted DEAR1 causes structural dysfunction

The researchers tested their theories in an experimental model using three-dimensional basement membrane culture systems designed to reproduce the tissue architecture of the mammary gland.

The first experiment tested whether placing a n
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Novel gene predicts local recurrence in early-onset breast cancer
2. Positive Results for Ophthotechs Novel Therapy for Wet AMD - Study of Anti-PDGF and Anti-VEGF Therapy Shows Significant Neovascular Regression and Enhanced Visual Outcome
3. Fixed Dosed Combination Agents and Novel Antihypertensives Are Expected to Face Tougher Formulary Restrictions
4. Compendia Bioscience Announces Collaboration with MDS Pharma Services to Deliver Novel Solution for Oncology Drug Development
5. Spiritual Leaders Teachings Collected in New Novel
6. Novel role of protein in generating amyloid-beta peptide
7. Novel cancer drug reduces neuroblastoma growth by 75 percent
8. Porter Novelli Begins Work With NHLBI on COPD Awareness Effort
9. Ethicon Endo-Surgery Novel Investigational Notes and SSL Devices Featured in 15 Presentations at Sages
10. Singapore First in Southeast Asia to Use Novel Treatment for Sports and Musculoskeletal Injuries
11. Mount Sinai researchers discover novel mechanisms that might causally link type-2 diabetes to Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel gene predicts local recurrence in early onset breast cancer
(Date:3/26/2015)... 2015 Let’s not lose focus of ... are today’s traffic magnets. Three out of 4 consumers ... their produce department, according to a Packaged Facts survey. ... are looking to add more fruits and vegetables to ... Day is April 2. As featured in the Chase’s ...
(Date:3/26/2015)... North American Seminars launches it new mobile ... providing information regarding OT PT continuing education courses to ... a leader in live hands PT continuing education ... and online continuing education courses. , Featured ... Master Clinicians Approach to Advanced Concepts in Examination and ...
(Date:3/26/2015)... 26, 2015 Florida Hospital teamed up with ... Your Health campaign and live Dr. Oz event, which took ... 21st. More than a thousand people came out to see ... , The world renowned cardiothoracic surgeon and Emmy award ... Hurtado and a panel of experts for the live health ...
(Date:3/26/2015)... March 26, 2015 The Baruch S. ... team of nationally renowned scientists to focus exclusively on ... move that nearly triples its research capacity and has ... on hepatitis B and liver cancer in the United ... Jinhong Chang, Ju Tao Guo and Ying-Hsiu Su – ...
(Date:3/26/2015)... March 26, 2015 “The SWEET Act is ... healthy options more available and help parents who are working ... is a reasonable approach to support public health, and we ... issue for the health of all families,” said Dr. Jane ... Health on the introduction of the Sugar-Sweetened Beverage Tax (SWEET) ...
Breaking Medicine News(10 mins):Health News:North American Seminars Launches Healthclick.com, a New Mobile Ready Website, Providing CME Course Information to PT, PTA, OT and ATC's 2Health News:North American Seminars Launches Healthclick.com, a New Mobile Ready Website, Providing CME Course Information to PT, PTA, OT and ATC's 3Health News:Florida Hospital Welcome Dr. Oz to Tampa and Invites the Community to Attend Educational Seminars Hosted by Florida Hospital Physicians 2Health News:Florida Hospital Welcome Dr. Oz to Tampa and Invites the Community to Attend Educational Seminars Hosted by Florida Hospital Physicians 3Health News:Baruch S. Blumberg Institute Recruits World-Class Hepatitis B Scientists 2Health News:Baruch S. Blumberg Institute Recruits World-Class Hepatitis B Scientists 3Health News:Baruch S. Blumberg Institute Recruits World-Class Hepatitis B Scientists 4Health News:National Alliance for Hispanic Health Statement on Introduction of SWEET Act in 114th Congress 2
... give back to Mercy Ships , ... Garden Valley. TX (Vocus) August ... greatest medal hopes at the Beijing Olympics, racer Paul Goodison, has announced ... medical care to the people of Africa. , , , , ,While ...
... service now available for pet owners and first responders in the ... pet safety company in the Northern Hemisphere, Rover Respond,R™ not only ... and animal rescue groups and provides peace of mind to pet ... ...
... rapid growth in popularity of DNA testing and genetic profiling is ... benefits available from genetic tests outweigh consumers, privacy concerns. From ... testing data to drive health and lifestyle decisions is gaining acceptance. ... ...
... ARE OBESE MAY CARRY ASTHMA TRAIT , A new ... may carry a specific trait or phenotype that causes ... are not obese with asthma. Researchers from Quebec, Canada ... cell counts, symptom perceptions, BMI/waist circumference, and waist-to-hip ratio ...
... ANN ARBOR, Mich., Aug. 4 The Kansas Health ... data system that,will enable the agency to analyze the ... system -- comprised of a data repository and a ... care data for several,state programs. Andy Allison, KHPA,s deputy ...
... nanotechnology, scientists already know that size does matter. , But ... Hill have shown that shape matters even more a ... for treating cancer and other diseases, from diabetes and multiple ... led by Joseph DeSimone, Ph.D., Chancellor,s Eminent Professor of Chemistry ...
Cached Medicine News:Health News:Olympic Sailing Hopeful Backs Hospital Ship Charity 2Health News:Olympic Sailing Hopeful Backs Hospital Ship Charity 3Health News:Olympic Sailing Hopeful Backs Hospital Ship Charity 4Health News:Emergencies Are No Longer Obstacles in Responsible Pet Care 2Health News:Emergencies Are No Longer Obstacles in Responsible Pet Care 3Health News:DNA Testing and Genetic Profiles Help Avoid Broken Hearts Polls Reveal 2Health News:DNA Testing and Genetic Profiles Help Avoid Broken Hearts Polls Reveal 3Health News:Chest Journal: August news briefs 2Health News:Kansas Health Policy Authority Awards Thomson Reuters Contract for Health Care Data Integration and Analysis Initiative 2Health News:Kansas Health Policy Authority Awards Thomson Reuters Contract for Health Care Data Integration and Analysis Initiative 3Health News:UNC study: shape, not just size, impacts effectiveness of emerging nanomedicine therapies 2Health News:UNC study: shape, not just size, impacts effectiveness of emerging nanomedicine therapies 3
(Date:3/26/2015)... SAN ANTONIO and STAEFA, Switzerland ... based on the Venture platform, wirelessly transmits sound from the ... better hearing ear. This allows people with single-sided deafness to ... before. The new fitting process for Phonak CROS II is ... users can instantly experience the benefits of the CROS solution ...
(Date:3/26/2015)... , March 26, 2015  Becton, Dickinson and ... it will commence offers to exchange all validly tendered ... CareFusion Corporation, a wholly owned subsidiary of BD, for ... the table below. A Registration Statement on Form S-4 ... New Notes was filed with the Securities and Exchange ...
(Date:3/26/2015)... 26, 2015  Oxis Biotech, Inc. (OXIS), ... Inc. [OTC: OXIS] and [Euronext Paris: OXI.PA] ... option agreement with the University of Pittsburgh ... Dr. Xiang-Qun Xie , Associate Dean ... School of Pharmacy.  These patents/intellectual properties relate ...
Breaking Medicine Technology:Phonak CROS II: The smart solution for single-sided deafness 2Becton, Dickinson and Company to Commence Exchange Offers 2Becton, Dickinson and Company to Commence Exchange Offers 3Becton, Dickinson and Company to Commence Exchange Offers 4Becton, Dickinson and Company to Commence Exchange Offers 5Oxis Biotech Executes Option Agreement to Certain Patents/Intellectual Properties Owned by the University of Pittsburgh 2Oxis Biotech Executes Option Agreement to Certain Patents/Intellectual Properties Owned by the University of Pittsburgh 3
... DALLAS, Aug. 3 ACCESS PHARMACEUTICALS, INC. ... update today on its clinical development strategy for ProLindac , ... be active in many solid tumors in human clinical studies. Access has ... dose levels and regimens of ProLindac monotherapy in cancer patients, provide additional data ...
... Grammy-Award winning artist and long-time (PRODUCT)RED supporter John Legend ... for his August 13th, 2009 concert at Madison Square Garden in ... Gap stores in the New York tri-state area will include a ... reserved RED(ZONE) section for John Legend,s MSG show. Even better, with ...
Cached Medicine Technology:Access Pharmaceuticals Provides Update on ProLindac Clinical Development Program 2Access Pharmaceuticals Provides Update on ProLindac Clinical Development Program 3Access Pharmaceuticals Provides Update on ProLindac Clinical Development Program 4John Legend and Gap Join (PRODUCT)RED(TM) to Help Eliminate AIDS in Africa with Exclusive (RED)ZONE Seating at Madison Square Garden 2John Legend and Gap Join (PRODUCT)RED(TM) to Help Eliminate AIDS in Africa with Exclusive (RED)ZONE Seating at Madison Square Garden 3
... Cochrane Reviews enable all those involved with ... with the very latest evidence in their ... becomes harder each year as the volume ... problem by delivering the best single source ...
Muscles Anatomy Flash Cards uses the time tested content and images from BryanEdwards.com....
Pocket Sports Medicine is the result of a collaboration between outstanding Editors and Contributors. The program covers the field so that both specialists and general orthopedists will find expert g...
... Cochrane Reviews enable all those involved with ... with the very latest evidence in their ... becomes harder each year as the volume ... problem by delivering the best single source ...
Medicine Products: