Navigation Links
Novel gene predicts local recurrence in early onset breast cancer
Date:5/6/2009

HOUSTON - A newly discovered gene known as DEAR1 is mutated in breast cancer and is an independent predictor of local recurrence-free survival in early-onset breast cancer, a research team headed by scientists at The University of Texas M. D. Anderson Cancer Center reports in the journal PLoS Medicine.

"The correlation with local recurrence is significant because so many young women have recurrences in the breast, and cancers that do recur tend to be more aggressive," said senior author Ann McNeill Killary, Ph.D., professor in M. D. Anderson's Department of Genetics. "Young age has been considered a risk factor for local recurrence and metastasis. It is important to understand the genetic mechanisms operating in early-onset breast cancer and to determine whether there is a way to identify young women who might be at a higher risk of recurrence."

After Killary's laboratory research discovered DEAR1 (ductal epithelium-associated ring chromosome 1) and implicated it in breast cancer, the team examined a tumor tissue microarray from 123 women whose breast cancer began between ages 25 and 49, all of whom advanced to invasive disease. Of these, 56 percent lacked DEAR1 expression in their tumors, which was associated with 58 percent local recurrence-free survival 15 years after surgery. For those with DEAR1 expression, local recurrence-free survival was 95 percent at 15 years.

"Immunohistochemical staining for DEAR1 could potentially be performed in any hospital setting, and such an assay might predict which women are at a high risk of recurrence and potentially help guide treatment decisions" Killary said, noting the results will need to be validated in a larger cohort of patients.

Breast cancer that develops before age 50 tends to be more aggressive and more likely to recur even in the absence of invasion of the lymph nodes at diagnosis. "Approximately one-fourth of women without nodal involvement will experience a
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Novel gene predicts local recurrence in early-onset breast cancer
2. Positive Results for Ophthotechs Novel Therapy for Wet AMD - Study of Anti-PDGF and Anti-VEGF Therapy Shows Significant Neovascular Regression and Enhanced Visual Outcome
3. Fixed Dosed Combination Agents and Novel Antihypertensives Are Expected to Face Tougher Formulary Restrictions
4. Compendia Bioscience Announces Collaboration with MDS Pharma Services to Deliver Novel Solution for Oncology Drug Development
5. Spiritual Leaders Teachings Collected in New Novel
6. Novel role of protein in generating amyloid-beta peptide
7. Novel cancer drug reduces neuroblastoma growth by 75 percent
8. Porter Novelli Begins Work With NHLBI on COPD Awareness Effort
9. Ethicon Endo-Surgery Novel Investigational Notes and SSL Devices Featured in 15 Presentations at Sages
10. Singapore First in Southeast Asia to Use Novel Treatment for Sports and Musculoskeletal Injuries
11. Mount Sinai researchers discover novel mechanisms that might causally link type-2 diabetes to Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel gene predicts local recurrence in early onset breast cancer
(Date:7/14/2014)... EurekaMag.com has newly published results of ... contagious liver disease that ranges in severity from ... serious, lifelong illness that attacks the liver. An estimated ... Hepatitis C virus infection of which approximately 80% of ... category covers all studies on Hepatitis C , the ...
(Date:7/14/2014)... "Medical devices, tests, and treatments are critical ... is a star when it comes to innovations in ... working on amazing products and ideas that are our ... to Dale Kaye CEO of the Innovation Tri-Valley ... brilliant minds and businesses that are leading society into ...
(Date:7/14/2014)... WI (PRWEB) July 14, 2014 Doctor ... announced the launch of their new company website. The ... valuable free information on chiropractic marketing. It's also a ... that Inception has to offer. , When contacted at ... the newest version of our main website. Our site ...
(Date:7/14/2014)... Essex, CT (PRWEB) July 14, 2014 Summer ... means vacations, camping, days at the beach, swimming and other ... want everyone to be safe, happy and healthy all summer ... of a list of the three must-have custom imprinted products ... first summer essential is of course sunblock. Sunscreen ...
(Date:7/13/2014)... 2014 Save the Date for the 2014 ... Jacksonville, FL , BOXWOODS & BowTies “A Modern Twist on ... The Women’s Board of Wolfson Children’s Hospital will ... to continue their ongoing commitment to raising funds for the ... , What: The 2014 Art & Antiques Show is a ...
Breaking Medicine News(10 mins):Health News:EurekaMag.com Publishes 64,900 New Studies on Hepatitis C 2Health News:Believing in the Possible – Innovation Tri-Valley’s Sixth Innovation Forum Examines the Tri-Valley’s Wealth of Innovators 2Health News:Believing in the Possible – Innovation Tri-Valley’s Sixth Innovation Forum Examines the Tri-Valley’s Wealth of Innovators 3Health News:Believing in the Possible – Innovation Tri-Valley’s Sixth Innovation Forum Examines the Tri-Valley’s Wealth of Innovators 4Health News:Doctor Mike Hamilton From Inception Chiropractic Websites Announces the Launch of Their New Website 2Health News:Why These Three Summer Essentials from 4AllPromos Can Improve Summer 2Health News:Save the Date for the 2014 Art & Antiques Show benefiting Wolfson Children's Hospital in Jacksonville, FL 2Health News:Save the Date for the 2014 Art & Antiques Show benefiting Wolfson Children's Hospital in Jacksonville, FL 3Health News:Save the Date for the 2014 Art & Antiques Show benefiting Wolfson Children's Hospital in Jacksonville, FL 4Health News:Save the Date for the 2014 Art & Antiques Show benefiting Wolfson Children's Hospital in Jacksonville, FL 5Health News:Save the Date for the 2014 Art & Antiques Show benefiting Wolfson Children's Hospital in Jacksonville, FL 6Health News:Save the Date for the 2014 Art & Antiques Show benefiting Wolfson Children's Hospital in Jacksonville, FL 7Health News:Save the Date for the 2014 Art & Antiques Show benefiting Wolfson Children's Hospital in Jacksonville, FL 8Health News:Save the Date for the 2014 Art & Antiques Show benefiting Wolfson Children's Hospital in Jacksonville, FL 9
... 21 LUMEDX Corporation, a leading,provider of ... introduces software to manage data and track ... Module empowers clinicians,by making critical clinical information ... For more information -- including a free ...
... May 20 The U.S. Department of,Health and ... advertising,campaign focusing on the quality of care available ... HHS, Centers for Medicare & Medicaid Services (CMS),in ... newspapers, promote Hospital,Compare ( http://www.hospitalcompare.hhs.gov ), an easy-to-use ...
... researchers,found that the frequency with which critically-ill patients ... a,multidisciplinary medical center such as Mayo Clinic compared ... the National Healthcare Safety,Network (NHSN). This is good ... are generally strong across the U.S. in intensive ...
... 2008) A newly published study presents data ... (COPD), including emphysema and chronic bronchitis, experienced markedly ... a combination of nebulized formoterol fumarate inhalation solution ... treatment with tiotropium alone. The two medications, ...
... BEDFORD, Mass., May 20 Hologic, Inc. (Nasdaq:,HOLX) today ... at the NASDAQ 21st Investor Program being held May ... parties are invited to listen to a live audio ... at 10:45 a.m.,BST on the investor section of the ...
... One of 35,000 Doctors Now Using E-Prescribing, ... (PCMA) is unveiling a new print ad campaign ... successfully use electronic,prescribing (e-prescribing) technology and who also ... new ad features Dr. R. David Allard, a ...
Cached Medicine News:Health News:New Anticoagulation Management Software Helps Clinics Enhance Efficiency and Improve Patient Safety 2Health News:National Ad Campaign Highlights Patient Ratings For More Than 1,000 Local U.S. Hospitals 2Health News:National Ad Campaign Highlights Patient Ratings For More Than 1,000 Local U.S. Hospitals 3Health News:Mayo Clinic Research Shows U.S. Intensive Care Units' Prevention of Pneumonia in Critically-ill Patients Generally Strong; Identifies Area of Improvement 2Health News:Mayo Clinic Research Shows U.S. Intensive Care Units' Prevention of Pneumonia in Critically-ill Patients Generally Strong; Identifies Area of Improvement 3Health News:Concomitant treatment with nebulized formoterol fumarate & tio-significant improvements -- COPD 2Health News:Concomitant treatment with nebulized formoterol fumarate & tio-significant improvements -- COPD 3Health News:Concomitant treatment with nebulized formoterol fumarate & tio-significant improvements -- COPD 4Health News:PCMA's New Ad Campaign: E-Prescribing is Ready Now 2
(Date:7/11/2014)... 11, 2014 Patient engagement has become ... organizations are turning to an assortment of marketing ... part of this evolving approach to patient engagement, ... and engage patients throughout their experiences with a ... By mapping the patient journey and employing a ...
(Date:7/11/2014)... , July 11, 2014 Research ... "Global Hypodermic Needles Market 2014-2018" report to their ... A hypodermic needle is a hollow needle commonly ... body or or to extract fluids from it. A ... or to inject substances that cannot be ingested. Hypodermic ...
(Date:7/11/2014)... , July 11, 2014 Research and ... of the "Immunoprotein Diagnostic Testing Market - ... highest CAGR of 6% and is expected to ... to their offering. ... diagnostic testing has been segmented according to immunoprotein ...
Breaking Medicine Technology:New Study Uses Six-Step Patient Journey as Framework for Consumer-Focused Marketing Opportunities 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3Immunoprotein Diagnostic Testing Market - Forecasts to 2019: Expected to grow at the highest CAGR of 6% and is expected to be valued at USD 4,943.0 million 2
... FREMONT, Calif. , Feb. 18 Vermillion, Inc.(Pink ... Peter S. Roddy has been elected to its Board ... Peter S. Roddy , currently Vice President and Chief Financial ...  "Peter has demonstrated excellence in financial management within the pharmaceutical ...
... CARLSBAD, Calif. , Feb. 18 AutoGenomics, ... today that the organization has been awarded the ISO ... system throughout the organization. TUV SUD America Inc. was ... AutoGenomics looks to expand its increasing role in the ...
Cached Medicine Technology:Vermillion Adds Peter S. Roddy to Board and Provides Corporate Update 2Vermillion Adds Peter S. Roddy to Board and Provides Corporate Update 3Vermillion Adds Peter S. Roddy to Board and Provides Corporate Update 4AutoGenomics Receives ISO Certification 2
... precision, ergonomics, and value!, Comfortable ... soft non-slip, contoured handle , Finer ... plunger spring action , Completely autoclavable ... the need for recalibration , Easy-to-read ...
10L...
... is ideal for repeated pipetting ... volume FInnpipettes offer the same ... Finnpipette Digital pipettes: New, ... Soft-touch tip ejection, Safety label, ...
... The Eppendorf Reference Series 2000 Pipette is ... stroke, a compact and robust design, and ... is used to operate the measuring stroke ... tip. Product features:Eppendorf "pipette/tip" system ensures utmost ...
Medicine Products: