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Novel gene predicts local recurrence in early-onset breast cancer
Date:5/5/2009

ormal DEAR1 gene into a cancer cell could re-establish a more normally functioning cell. Killary noted that when tumor cell lines containing a DEAR1 mutation were grown in the culture system, the cells showed aberrant growth and formed large clumps of cells with no organized structure. Inserting a normal DEAR1 gene restored acinar morphogenesis and resulted in structures that were very similar to those present in normal breast tissue.

In a second tissue culture experiment, the researchers shut down expression of the DEAR1 gene in normal breast epithelial cells, which caused the cells to lose their ability to form proper structures.

In addition, the researchers used immunohistochemical staining to examine DEAR1 expression in 14 samples of ductal carcinoma in situ (precancerous abnormalities) with adjacent normal epithelium and in the corresponding invasive cancer from the same patient. They found that DEAR1 was expressed in all the normal ducts in the glands but was lost or downregulated in the transition from normal epithelium to DCIS in 10 of the 14 patient samples.


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Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

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