Navigation Links
Novel gene predicts local recurrence in early-onset breast cancer
Date:5/5/2009

recurrence up to 12 years after surgery," Killary said. Of the 123 early-onset patients, 72 percent had no lymph node involvement at diagnosis.

Low expression associated with triple-negative breast cancer

While the researchers found that loss of DEAR1 expression correlated significantly with local recurrence, it did not correlate with overall survival in this young cohort.

However, lack of DEAR1 expression was associated with triple-negative breast cancer, which indicates poor prognosis because it lacks estrogen or progesterone receptors and does not express HER2, three targets for therapy. Lack of DEAR1 expression also was associated with a strong family history of breast cancer.

The team discovered the gene in a region of the human genome that has been implicated in other epithelial tumors, including colon and pancreatic cancers, and that the researchers suspected might harbor an important tumor suppressor gene. Finding that DEAR1 was mutated in breast cancer suggested that it could play a role in the initiation and progression of the disease.

The researchers found evidence that DEAR1 plays a critical regulatory role in acinar morphogenesis, or the orderly development and differentiation of the terminal ductal lobular units (TDLU) in the breast. TDLUs are structures present at the ends of a branching network of ducts in the normal mammary gland which also are thought to be the site of origin of many breast cancers. Mutations in DEAR1 lead to cellular disorganization, lack of cell differentiation, and loss of normal structure in breast tissue - all hallmarks of a transition to malignancy.

Mutated or deleted DEAR1 causes structural dysfunction

The researchers tested their theories in an experimental model using three-dimensional basement membrane culture systems designed to reproduce the tissue architecture of the mammary gland.

The first experiment tested whether placing a n
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Positive Results for Ophthotechs Novel Therapy for Wet AMD - Study of Anti-PDGF and Anti-VEGF Therapy Shows Significant Neovascular Regression and Enhanced Visual Outcome
2. Fixed Dosed Combination Agents and Novel Antihypertensives Are Expected to Face Tougher Formulary Restrictions
3. Compendia Bioscience Announces Collaboration with MDS Pharma Services to Deliver Novel Solution for Oncology Drug Development
4. Spiritual Leaders Teachings Collected in New Novel
5. Novel role of protein in generating amyloid-beta peptide
6. Novel cancer drug reduces neuroblastoma growth by 75 percent
7. Porter Novelli Begins Work With NHLBI on COPD Awareness Effort
8. Ethicon Endo-Surgery Novel Investigational Notes and SSL Devices Featured in 15 Presentations at Sages
9. Singapore First in Southeast Asia to Use Novel Treatment for Sports and Musculoskeletal Injuries
10. Mount Sinai researchers discover novel mechanisms that might causally link type-2 diabetes to Alzheimers disease
11. A Decision Beyond Life and Death: Novel Examines Effects of Controversial Procedure on Patients, Their Families and Doctors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel gene predicts local recurrence in early-onset breast cancer
(Date:7/3/2015)... ... July 03, 2015 , ... Brendon Burchard's new High ... of media attention. In an effort to spread the news, a comprehensive review ... days many people are feeling overwhelmed by stress and fatigue," reports Hendricks. "Many ...
(Date:7/3/2015)... ... July 03, 2015 , ... B. E. ... been retained to lead a national president recruitment for Regional Care, ... healthcare industry, B. E. Smith has recently placed more than 1,000 healthcare executives ...
(Date:7/3/2015)... ... July 03, 2015 , ... Jennifer Renee Hanes, DO is the new ... the largest network of independent freestanding emergency rooms in the United States. , “We ... Sienna Plantation facility,” said Executive Medical Director of First Choice Emergency Room, Dr. James ...
(Date:7/3/2015)... ... July 03, 2015 , ... The Celebrity Dresses is ... dresses similar to those of celebrities will have the opportunity to get 10% discount ... This ensures that people do not have to use coupon codes or remember redemption ...
(Date:7/2/2015)... (PRWEB) , ... July 02, 2015 , ... ... Donna Edwards (D-Md.) for her introduction of the Stop Overdose Stat (S.O.S.) Act ... by Senator Jack Reed (D-R.I.), this Act seeks to decrease drug overdose – ...
Breaking Medicine News(10 mins):Health News:High Performance Academy - Review Of Brendon Burchard's New High Performance Training Program Released 2Health News:High Performance Academy - Review Of Brendon Burchard's New High Performance Training Program Released 3Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 2Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 3Health News:Dr. Jennifer Renee Hanes Named by First Choice Emergency Room as Medical Director of Missouri City, TX Facility 2Health News:Dr. Jennifer Renee Hanes Named by First Choice Emergency Room as Medical Director of Missouri City, TX Facility 3Health News:Celebrity Fashion Summer Party Dresses on sale at TheCelebrityDresses.com 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 3
... 15 years ago scientists discovered a way to stop ... finding holds tantalizing promise for medical science, but so ... known as RNA interference, in living cells., Now scientists ... University in Atlanta have succeeded in using nanotechnology known ...
... for cancer research is complete. There are more unclimbed ... mountains to challenge., ... the Big Expedition for Cancer Research determined that they,had reached the safe ... hours, they battled unstable snow, ice and rock to,move within 500 vertical ...
... Health Ministers Meet to Focus on Link Between Health and,Economic ... It has long been accepted that greater wealth allows ... Does greater health lead,to greater wealth, both on a personal ... of health, international experts, and,over 500 delegates from the 53 ...
... by last year,s "Live,Your Best Life Spa Week" held at ... legacy of giving back by once again hosting the,most deserving ... contest,people all across the country can nominate contestants who are ... will enjoy a four-day,three-night retreat at the country,s top rated ...
... the hope in transplantation and raise awareness of the ... need for organ and tissue donations, ... (JRI) and world-renowned mountain,climber and heart transplant recipient, Kelly Perkins, are ... Heart. Share the,Beat" where Perkins and her husband Craig will scale ...
... urge athletes, coaches and trainers to follow simple steps ... to ... 23 Methicillin-resistant,Staphylococcus aureus, commonly referred to as MRSA, ... a class of common antibiotics that,includes methicillin, penicillin, amoxicillin ...
Cached Medicine News:Health News:Gene silencer and quantum dots reduce protein production to a whisper 2Health News:Gene silencer and quantum dots reduce protein production to a whisper 3Health News:Big Expedition Ends Peak 8290 Attempt 500 Feet From the Summit 2Health News:Big Expedition Ends Peak 8290 Attempt 500 Feet From the Summit 3Health News:Big Expedition Ends Peak 8290 Attempt 500 Feet From the Summit 4Health News:Big Expedition Ends Peak 8290 Attempt 500 Feet From the Summit 5Health News:Does Better Health Lead to Better Wealth? 2Health News:Does Better Health Lead to Better Wealth? 3Health News:Miraval Tucson to Continue Legacy of Awarding Spa Vacation 2Health News:Heart Recipient Kelly Perkins Scales Half Dome to Support 'Exercise Your Heart. Share The Beat' 2Health News:American Academy of Dermatology Research Shows Athletes Susceptible to Antibiotic-Resistant Staph Infections 2Health News:American Academy of Dermatology Research Shows Athletes Susceptible to Antibiotic-Resistant Staph Infections 3Health News:American Academy of Dermatology Research Shows Athletes Susceptible to Antibiotic-Resistant Staph Infections 4Health News:American Academy of Dermatology Research Shows Athletes Susceptible to Antibiotic-Resistant Staph Infections 5
(Date:7/4/2015)... , July 4, 2015 ... for patients with unresectable metastatic colorectal cancer in ... that organ Patients with unresectable metastatic ... the liver experienced the greatest improvement in Progression-Free ... of SIR-Spheres Y-90 resin microspheres to a current ...
(Date:7/3/2015)... July 4, 2015 A global ... hypertension, diabetes and thyroid disorders in Central and ... platforms and a major conference dedicated to these diseases. ... Manage Diabetes Online , Manage Hypertension Online ... and operated by EXCEMED - combine the ...
(Date:7/3/2015)... July 3, 2015 Un ... épidémies que sont l,hypertension, le diabète et les ... plateformes éducatives gratuites et d,une conférence majeure dédiée ... http://photos.prnewswire.com/prnh/20150630/227033 ) , Les formations ... , Prendre en charge l,hypertension en ligne ...
Breaking Medicine Technology:New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 2New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 3New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 4Combating Three Major Chronic Diseases in Central and South-East Asia With Medical Education 2Lutter contre trois maladies chroniques majeures en Amérique latine grâce à la formation médicale 2Lutter contre trois maladies chroniques majeures en Amérique latine grâce à la formation médicale 3
... , WILMINGTON, Del. , Jan. ... plans have been approved by the Food & Drug Administration since their ... and report on how well these plans have actually been working in ... will be the topic of an open industry webinar at 12 ...
... , ST. LOUIS , Jan. 12 ... entered a distribution agreement with Eka Chemicals to offer Eka,s ... small molecules, peptides and proteins in the pharmaceutical and biotechnology ... and Puerto Rico , and expands Sigma-Aldrich,s portfolio ...
Cached Medicine Technology:REMS Assessment Webinar to Examine How to Measure Effectiveness of Drug Safety Plans 2Sigma-Aldrich Becomes the Sole U.S. and Canada Distributor of Kromasil(R) HPLC Columns Through Agreement With Eka Chemicals 2Sigma-Aldrich Becomes the Sole U.S. and Canada Distributor of Kromasil(R) HPLC Columns Through Agreement With Eka Chemicals 3Sigma-Aldrich Becomes the Sole U.S. and Canada Distributor of Kromasil(R) HPLC Columns Through Agreement With Eka Chemicals 4
... Designed for Western, Northern, or Southern ... gels with dimensions as large as ... internal cooling base for temperature controlled ... power leads. Additional blotting ...
... electrophoretic transfer apparatus incorporating state-of-the-art plate electrodes for ... for a very close positioning of the electrodes ... source such as a battery charger, creates a ... rapid and exact electrophoretic transfer. ...
... power supply. Flexibility for ... Transfers. Native Enzyme, High ... Faster, Higher-Efficiency Transfers via Plate ... with Movable Electrodes. Simple ...
... 2 gel holder cassettes, cell ... fiber pads, blot absorbent paper ... Trans-Blot transfer cell, used with ... performs efficient, high-intensity electrophoretic transfers. ...
Medicine Products: