Navigation Links
Novel gene predicts local recurrence in early-onset breast cancer
Date:5/5/2009

recurrence up to 12 years after surgery," Killary said. Of the 123 early-onset patients, 72 percent had no lymph node involvement at diagnosis.

Low expression associated with triple-negative breast cancer

While the researchers found that loss of DEAR1 expression correlated significantly with local recurrence, it did not correlate with overall survival in this young cohort.

However, lack of DEAR1 expression was associated with triple-negative breast cancer, which indicates poor prognosis because it lacks estrogen or progesterone receptors and does not express HER2, three targets for therapy. Lack of DEAR1 expression also was associated with a strong family history of breast cancer.

The team discovered the gene in a region of the human genome that has been implicated in other epithelial tumors, including colon and pancreatic cancers, and that the researchers suspected might harbor an important tumor suppressor gene. Finding that DEAR1 was mutated in breast cancer suggested that it could play a role in the initiation and progression of the disease.

The researchers found evidence that DEAR1 plays a critical regulatory role in acinar morphogenesis, or the orderly development and differentiation of the terminal ductal lobular units (TDLU) in the breast. TDLUs are structures present at the ends of a branching network of ducts in the normal mammary gland which also are thought to be the site of origin of many breast cancers. Mutations in DEAR1 lead to cellular disorganization, lack of cell differentiation, and loss of normal structure in breast tissue - all hallmarks of a transition to malignancy.

Mutated or deleted DEAR1 causes structural dysfunction

The researchers tested their theories in an experimental model using three-dimensional basement membrane culture systems designed to reproduce the tissue architecture of the mammary gland.

The first experiment tested whether placing a n
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Positive Results for Ophthotechs Novel Therapy for Wet AMD - Study of Anti-PDGF and Anti-VEGF Therapy Shows Significant Neovascular Regression and Enhanced Visual Outcome
2. Fixed Dosed Combination Agents and Novel Antihypertensives Are Expected to Face Tougher Formulary Restrictions
3. Compendia Bioscience Announces Collaboration with MDS Pharma Services to Deliver Novel Solution for Oncology Drug Development
4. Spiritual Leaders Teachings Collected in New Novel
5. Novel role of protein in generating amyloid-beta peptide
6. Novel cancer drug reduces neuroblastoma growth by 75 percent
7. Porter Novelli Begins Work With NHLBI on COPD Awareness Effort
8. Ethicon Endo-Surgery Novel Investigational Notes and SSL Devices Featured in 15 Presentations at Sages
9. Singapore First in Southeast Asia to Use Novel Treatment for Sports and Musculoskeletal Injuries
10. Mount Sinai researchers discover novel mechanisms that might causally link type-2 diabetes to Alzheimers disease
11. A Decision Beyond Life and Death: Novel Examines Effects of Controversial Procedure on Patients, Their Families and Doctors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel gene predicts local recurrence in early-onset breast cancer
(Date:8/22/2014)... 2014 A new, online conference is coming ... summit is no-cost and open to everyone. Over 20 ... tips and advice on how to stop emotional eating, start ... Mindful eating is not a diet. The concept is ... of an "eat this, don't eat that" approach. , You ...
(Date:8/22/2014)... 22, 2014 For patients who need surgery for ... procedure is the least often used, reports a study ... , official journal of the Congress of Neurological ... Williams & Wilkins , a part of Wolters ... good pain relief at much lower cost than other ...
(Date:8/22/2014)... New York, NY (PRWEB) August 22, 2014 ... Theresa Caputo tickets in Kalamazoo, New Orleans, Albuquerque ... family after death, the “Long Island Medium,” Theresa Caputo, allows ... on Long Island. She is part of a close knit ... child. After speaking with a spiritual healer, realized she had ...
(Date:8/22/2014)... FL (PRWEB) August 22, 2014 ... continues expansion of products in providing new recipe cards, ... casual wear. , Hailing from Clearwater, Florida, Pirate ... appreciate having 1 card with two to three recipes ... the recipes on the website. The ...
(Date:8/22/2014)... According to the new research report "Isocyanate Market ... Forecast to 2019" defines and segments the isocyanate ... market value. The isocyanate material market value will ... significant CAGR from 2014 to 2019. , Browse ... through 286 pages and in-depth TOC on "Isocyanate ...
Breaking Medicine News(10 mins):Health News:20 Top Experts Discuss How to Unravel the Food-Mood Connection 2Health News:More common procedures for painful facial tics carry high costs, reports study in Neurosurgery 2Health News:Theresa Caputo Tickets in Kalamazoo at Wings Stadium, Saenger Theatre in New Orleans, Kiva Auditorium in Albuquerque and Rapid City at Don Barnett Arena Now Available 2Health News:Pirate Jonny's Caribbean BBQ Rubs, Seasonings & Sauces Get New Look by Hoisting New Recipe Card Creations and New Clothing Apparel for its Logos 2Health News:Isocyanate Market An Industry Growing Steadily Projected to Grow $38,729 Million by 2019 - Report by MarketsandMarkets 2Health News:Isocyanate Market An Industry Growing Steadily Projected to Grow $38,729 Million by 2019 - Report by MarketsandMarkets 3Health News:Isocyanate Market An Industry Growing Steadily Projected to Grow $38,729 Million by 2019 - Report by MarketsandMarkets 4
... and Washington University School of Medicine in St. Louis have ... 16 to// use of all-terrain vehicles (ATVs). This call was ... ,Children have no experience or training in driving motorized vehicles, ... see what's coming up ahead of them very well,' says ...
... with Florida-based Roskamp Institute to conduct a study on ... in Alzheimer's disease. // ,The Dublin Ageing ... Psychiatry from St James’ Hospital, Beaumont Hospital, James Connolly ... Adelaide and Meath Hospital and St Patrick’s Hospital will ...
... herbs, has now uncorked a new product: herbal wine. // ... a resident of tourist town Pokhara in western Nepal, whose ... ,For many families, alcohol is an integral part of life, ... liquors thrive in Nepal's markets along with foreign beers, whiskeys ...
... tailoring the intensity of radiation to individual patients and ... for those// suffering medulloblastoma. ,A team ... has announced that improved treatment measures for childhood brain ... of children with this disease. , ,The ...
... strong bones, strong and healthy teeth, and healthy muscles and ... vital to take plenty of calcium, especially in the adolescent ... osteoporosis. ,The growth of bone mass takes place ... by calcium in milk, cheese, yogurt, other dairy products, leafy ...
... drugs are released within a cancer cells.// ,A ... first time ever details of how drugs are released within ... the ability to deliver drugs to a specific target without ... indiscriminate delivery of drugs into every cell of the body ...
Cached Medicine News:Health News:Call To Ban Use Of ATVs By Children 2Health News:Nepal Uncorks 'Herbal Wine' 2Health News:Survival rates improve with better treatment options for medulloblastoma 2Health News:Survival rates improve with better treatment options for medulloblastoma 3Health News:Study Findings Could Help In Developing A Better Drug Delivery System 2Health News:Study Findings Could Help In Developing A Better Drug Delivery System 3Health News:Study Findings Could Help In Developing A Better Drug Delivery System 4
(Date:8/22/2014)... MC Medical, a subsidiary of Mitsubishi Corporation (MCM), and Minimally ... medical device company, have formally agreed to an exclusive ... in Japan . It is anticipated that ... in the latter half of 2015. ... in endoscopic surgery market in Japan . ...
(Date:8/22/2014)... ITHACA, N.Y. , Aug. 22, 2014 /PRNewswire/ ... computed tomography (CT) imaging facility, is using the ... 4D and even 5D imaging to researchers and ... just launched, asks "What would YOU do if ... the possibility to researchers and explorers everywhere, from ...
(Date:8/22/2014)... FREMONT, Calif. , Aug. 22, 2014  WaferGen ... an underwritten public offering of units of common stock ... for gross proceeds of $20 million, prior to deducting ... the Company.  The shares and warrants are immediately separable ... stock are expected to begin trading on The NASDAQ ...
Breaking Medicine Technology:MC Medical agrees to be the exclusive distributor of FloShield products in Japan 2Cornell's X-ray Imaging Lab Director Uses Kickstarter Campaign to "Democratize" Advanced 3D Imaging 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 3WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 4
... , BOSTON, Nov. 20 The United States ... an earlier District Court ruling yesterday, approving a settlement ... against AstraZeneca Pharmaceuticals ( AZN). , (Logo: http://www.newscom.com/cgi-bin/prnh/20080317/AQM144LOGO ... consumers who purchased the pharmaceutical giant,s prostate cancer drug ...
... , LOUISVILLE, Ky., Nov. 20 ... a new initiative in the war on methamphetamine. The ... program that enforces purchase limitations on over-the-counter (OTC) medicines containing ... technology for NPLEx is based on a system that was ...
Cached Medicine Technology:U.S. Court of Appeals Upholds AstraZeneca AWP Settlement 2U.S. Court of Appeals Upholds AstraZeneca AWP Settlement 3National System Aims To Minimize Diversion of Cold and Allergy Medicine in Methamphetamine Production 2National System Aims To Minimize Diversion of Cold and Allergy Medicine in Methamphetamine Production 3
Digital Ultrasonic Diagnostic Imaging System...
Quantitative Plasma-based Factor XIII Incorporation Assay Kit...
Pefakit PiCT LMWH Controls...
Calcium Chloride 0.020M - 4 ml...
Medicine Products: