Navigation Links
Novel gene predicts local recurrence in early-onset breast cancer
Date:5/5/2009

HOUSTON - A newly discovered gene known as DEAR1 is mutated in breast cancer and is an independent predictor of local recurrence-free survival in early-onset breast cancer, a research team headed by scientists at The University of Texas M. D. Anderson Cancer Center reports in the journal PLoS Medicine.

"The correlation with local recurrence is significant because so many young women have recurrences in the breast, and cancers that do recur tend to be more aggressive," said senior author Ann McNeill Killary, Ph.D., professor in M. D. Anderson's Department of Genetics. "Young age has been considered a risk factor for local recurrence and metastasis. It is important to understand the genetic mechanisms operating in early-onset breast cancer and to determine whether there is a way to identify young women who might be at a higher risk of recurrence."

After Killary's laboratory research discovered DEAR1 (ductal epithelium-associated ring chromosome 1) and implicated it in breast cancer, the team examined a tumor tissue microarray from 123 women whose breast cancer began between ages 25 and 49, all of whom advanced to invasive disease. Of these, 56 percent lacked DEAR1 expression in their tumors, which was associated with 58 percent local recurrence-free survival 15 years after surgery. For those with DEAR1 expression, local recurrence-free survival was 95 percent at 15 years.

"Immunohistochemical staining for DEAR1 could potentially be performed in any hospital setting, and such an assay might predict which women are at a high risk of recurrence and potentially help guide treatment decisions" Killary said, noting the results will need to be validated in a larger cohort of patients.

Breast cancer that develops before age 50 tends to be more aggressive and more likely to recur even in the absence of invasion of the lymph nodes at diagnosis. "Approximately one-fourth of women without nodal involvement will experience a
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Positive Results for Ophthotechs Novel Therapy for Wet AMD - Study of Anti-PDGF and Anti-VEGF Therapy Shows Significant Neovascular Regression and Enhanced Visual Outcome
2. Fixed Dosed Combination Agents and Novel Antihypertensives Are Expected to Face Tougher Formulary Restrictions
3. Compendia Bioscience Announces Collaboration with MDS Pharma Services to Deliver Novel Solution for Oncology Drug Development
4. Spiritual Leaders Teachings Collected in New Novel
5. Novel role of protein in generating amyloid-beta peptide
6. Novel cancer drug reduces neuroblastoma growth by 75 percent
7. Porter Novelli Begins Work With NHLBI on COPD Awareness Effort
8. Ethicon Endo-Surgery Novel Investigational Notes and SSL Devices Featured in 15 Presentations at Sages
9. Singapore First in Southeast Asia to Use Novel Treatment for Sports and Musculoskeletal Injuries
10. Mount Sinai researchers discover novel mechanisms that might causally link type-2 diabetes to Alzheimers disease
11. A Decision Beyond Life and Death: Novel Examines Effects of Controversial Procedure on Patients, Their Families and Doctors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel gene predicts local recurrence in early-onset breast cancer
(Date:8/30/2015)... ... August 31, 2015 , ... This month, top rated New ... assisted living facilities and nursing homes protect their residents from neglect and improper ... experts at the company, security systems don’t just protect; they also help monitor ...
(Date:8/30/2015)... Boca Raton, Fl (PRWEB) , ... August 30, ... ... that Brian Spector has joined the company as the new Global Communications Director ... broadcasting and public relations experience having spent the last 16 years doing on-air ...
(Date:8/30/2015)... ... August 30, 2015 , ... ... devices for the treatment of prostate cancer, has announced the roll-out of its ... the treatment center in Puerto Vallarta, Mexico. , The Sonablate® technology currently in ...
(Date:8/29/2015)... ... 29, 2015 , ... "I have been a licensed physical ... specialize in manual therapy, and my invention will provide headache sufferers a solution ... muscle dysfunction throughout the body." , They developed THE RELIEVER to alleviates headaches, ...
(Date:8/29/2015)... ... August 29, 2015 , ... Next weekend is Labor Day weekend, the last ... on September 22nd this year). For IT security personnel, it should also mark the ... prove far more costly than a simple headache. , Joe Caruso, founder and CEO-CTO ...
Breaking Medicine News(10 mins):Health News:Total Security Announces Security Systems Tips for New York Assisted Living Facilities and Nursing Homes 2Health News:Total Security Announces Security Systems Tips for New York Assisted Living Facilities and Nursing Homes 3Health News:InHealth Media Appoints New Global Communications Director 2Health News:Image Fusion Technology Combines MRI and Ultrasound Images to Treat Prostate Cancer 2Health News:Inventors and InventHelp Clients Develops Tension Reliever (LGI-1951) 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 3Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 4
... on,Mental Illness (NAMI) is preparing to grade each of ... public to help by taking an online survey,-- and ... at http://www.nami.org/mentalhealthservices and,includes a version in Spanish., ... on America,s Mental,Healthcare System for Serious Mental Illnesses" ...
... Edward Duckworth is part of a new generation of ... on patients. , At Loyola University Hospital, Duckworth is ... aneurysms and to dramatically reduce seizures in epilepsy patients. ... or face, Duckworth is reaching the brain through much ...
... America,s Agenda to Launch Summit Conversations Series, ... All will be honoring Rep. Richard "Dick" Gephardt, ... commitment to affordable,health care for every American at ... the spirit of "health care for all Americans,",America,s ...
... beer, ... Stampede Light Plus(R), DALLAS, Aug. 20 ... Jessica Simpson,s daisy dukes body and healthy,lifestyle. The all-American beauty and ... choices. But she also makes,those smart choices with the beer she ...
... The National Institutes of,Health estimates that 45 million ... these headaches sufferers, the pain they experience is ... in your life, there,are many options to find ... Headaches result when muscles and blood vessels outside ...
... (DIA) will host Evidence-based Medicine and Health Technology ... Alexandria, VA). , ... ... 20, 2008 -- The http://www.diahome.org/DIAHome/ [Drug ...
Cached Medicine News:Health News:Grading the States; Mental Health Services Survey 2Health News:Brain surgery is getting easier on patients 2Health News:Brain surgery is getting easier on patients 3Health News:America's Agenda to Honor Former House Majority Leader Richard Gephardt at Democratic National Convention 2Health News:Jessica Simpson Lends Healthy Image for Drink Smart Campaign 2Health News:Jessica Simpson Lends Healthy Image for Drink Smart Campaign 3Health News:Figure Skater Peggy Fleming Teams With HealthSaver: To Relieve Headaches, Be Proactive 2Health News:Figure Skater Peggy Fleming Teams With HealthSaver: To Relieve Headaches, Be Proactive 3Health News:Figure Skater Peggy Fleming Teams With HealthSaver: To Relieve Headaches, Be Proactive 4Health News:Figure Skater Peggy Fleming Teams With HealthSaver: To Relieve Headaches, Be Proactive 5Health News:DIA Conference to Provide New Paradigms in Evidence-Based Medicine and Health Technology Assessment 2
(Date:8/27/2015)... , Aug. 27, 2015  A recent study ... Knee Journal, compared the Arthrosurface HemiCAP® Wave implant, ... versus an "onlay" design implant for isolated patellofemoral ... in function and pain scores, none of the ... osteoarthritis (OA). However, 53% of the patients in ...
(Date:8/27/2015)... 27, 2015 ieCrowd™ today announced the ... development of the company,s supplemental oxygen delivery device, ... being developed by ieCrowd,s subsidiary Smart Oxygen Solutions ... demand for oxygen based on level of activity.  ... for the Smart Oxygen device would require a ...
(Date:8/27/2015)... , Aug. 27, 2015  Now that Intuitive ... Da Vinci S™ surgical robot, hospitals with robotic surgery ... They also need to see where they stand with ... the right patients? Have they adopted best practices for ... program in the future? ECRI Institute, which ...
Breaking Medicine Technology:Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 2Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 3Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 2Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 3Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 4ECRI Institute's New Robotic Surgery Service Helps Hospitals Brace for Change 2ECRI Institute's New Robotic Surgery Service Helps Hospitals Brace for Change 3
... Texas, April 8, 2011 Novation, the leading health ... St. Jude Medical (St. Paul, MN) to its portfolio ... St. Jude Medical is a leading provider of ... patients. The company provides a full portfolio of arrhythmia ...
... April 8, 2011 Pacira Pharmaceuticals, Inc. (NASDAQ: ... Scibetta, chief financial officer, is scheduled to present at the ... April 15, 2011, at 11:30 a.m. EDT being held at ... City. Mr. Scibetta is expected to present an overview of ...
Cached Medicine Technology:Novation Announces the Addition of St. Jude Medical to the Cardiac Rhythm Management Products Portfolio 2Pacira Pharmaceuticals to Present at BioCentury Future Leaders in the Biotech Industry Conference 2
Sera available in three levels for the control of accuracy and precision for up to 31 analytes...
Human based material available in two levels for thecontrol of percision for up to 10 analytes...
Human based material available in two levels for the control of accuracy and precision for upto 23 analytes....
Human based assayed sera available in three levels for the control of accuracy and precision for up to 25 analytes...
Medicine Products: