Navigation Links
Novel enzyme inhibitor paves way for new cancer drug
Date:5/15/2008

tively targeted the PI3K lipid kinases.

In collaboration with Meenhard Herlyn, D.V.M., D.Sc., at the Wistar Institute, the Marmorstein group then tested the effectiveness of the agent using melanoma cell cultures. Melanoma was used as a model system for the study because the signaling pathway regulated by PI3K is highly mutated in melanoma, Marmorstein says.

In addition to PI3K, the PI3K signaling pathway includes another kinase called AKT, and a phosphatase, PTEN, which serves as a tumor suppressor.

What you will often find is that one of those three proteins, and sometimes others, are mutated in cancer, Marmorstein says.

Studies with human melanoma cells showed that E5 blocked AKT activity, thereby inhibiting the growth of cells. Further studies in 3D cultures of melanoma cells showed the agent also prevented melanoma cell invasion.

What weve shown is that our inhibitor can find the kinase that its designed to inhibit without inhibiting other kinases, which could produce unwanted side effects, he says.

Marmorstein says the group plans to improve upon the E5 compound by creating organometallic inhibitors that target other isoforms, or types, of PI3K. The PI3K family of kinases includes four types: alpha, beta, delta and gamma. Each type is associated with particular biological pathways and performs various functions in the cell.

Though some of the PI3K types are associated with cancer, others are not. The trick to building inhibitors with low side effects and toxicity is to create inhibitors that knock out the troublesome isoforms without disrupting the other types, Marmorstein says


'/>"/>

Contact: Abbey J. Porter
aporter@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting
2. Novel mechanisms controlling insulin release and fat deposition discovered
3. Preliminary Results from Phase 2 Genzyme Study Highlight Potential of Novel Oral Compound for Gaucher Disease
4. Discovery of a novel mechanism for the development of colon cancer
5. TorreyPines Therapeutics Licenses Intellectual Property from Johns Hopkins Related to Novel Uses of Glutamate Receptor Antagonists for Prevention, Treatment of Stroke, Heart Attack
6. Latona Announces the Acquistion of Patent Rights and Orphan Drug Status to Novel Late Stage Drug Compound for Juvenile and Adult Rheumatoid Arthritis
7. Scientists identify novel way to prevent cardiac fibrosis
8. Registry unveils real-world data on novel excel stent
9. Researchers sharpen search for new marine medicines with novel techniques
10. Increased hepcidin expression: A novel oncogenic signalling mechanism
11. Novel discovery by Einstein scientists could lead to much-needed kidney failure treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... Waycross, Georgia (PRWEB) , ... July 31, 2015 , ... Easter Seals Southern Georgia’s Heels ... Park near Waycross, Georgia. Start time will be 7:30 AM. The duathlon is a 2 ... quarter mile swim in Laura Walker Lake, a 13 mile bike, and a 3 mile ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... applies when purchasing disability insurance, where price is an important factor to clients ... a leading insurance carrier, offers the Preferred Producer Multi-Life Discount program, where advisers ...
(Date:7/30/2015)... ... , ... When responsible for the care of an aging loved one, summer ... mind: What happens if mom falls? Who will remind Dad to take his medications? ... But not taking time away from caregiving responsibilities can lead to bigger problems – ...
(Date:7/30/2015)... Turks & Caicos Islands, BWI (PRWEB) , ... July 31, 2015 , ... The Venetian ... offer for fall, 2015. Guests who stay at the Venetian will save 40% on ... , The fall months are always quiet in the Turks & Caicos, providing a chance ...
(Date:7/30/2015)... ... 2015 , ... World Patent Marketing, a vertically integrated manufacturer ... can help people during emergencies. , "The worldwide mobile health market revenue will ... World Patent Marketing. "Currently, there are about 97,000 mobile health apps available in ...
Breaking Medicine News(10 mins):Health News:Heels & Wheels for Megan's House Set for Saturday August 22, 2015 in Waycross, Georgia 2Health News:Secura Consultants Gives Advisers Competitive New Edge with Multi-Life Discount Program 2Health News:Aging Life Care Association™ Experts Offer Tips for Caregivers in Need of Vacation Time 2Health News:Aging Life Care Association™ Experts Offer Tips for Caregivers in Need of Vacation Time 3Health News:The Venetian on Grace Bay in Turks & Caicos Islands Offers 40% Savings This Fall. 2Health News:Emergency Alert Can Be A Rude Awakening Without World Patent Marketings New App Invention, I AM FINE 2Health News:Emergency Alert Can Be A Rude Awakening Without World Patent Marketings New App Invention, I AM FINE 3Health News:Emergency Alert Can Be A Rude Awakening Without World Patent Marketings New App Invention, I AM FINE 4Health News:Emergency Alert Can Be A Rude Awakening Without World Patent Marketings New App Invention, I AM FINE 5
... News) -- Men develop type 2 diabetes at a lower ... why men have higher rates of diabetes in many parts ... 51,920 men and 43,137 women in Scotland with diabetes and ... men and 33.69 in women. This difference was most noticeable ...
... (HealthDay News) -- Women with polycystic ovary syndrome (PCOS), an ... to have parents with some form of heart disease, according ... between PCOS and other family medical conditions, we might be ... an earlier stage," the study,s lead author, Michael Davies, an ...
... , FRIDAY, Oct. 7 (HealthDay News) -- Boys with autism ... developing infants seen in their head size, height and weight, ... offer new clues about the underlying mechanisms of autism. A ... larger brain. Boys with brain and body "overgrowth" ...
... that high-calorie energy drink or soda might present more ... double-blind, placebo-controlled study that examined responses to stimulants, an ... or she will respond to other stimulant drugs, possibly ... serious drugs of abuse, such as amphetamine and cocaine. ...
... through organ transplantation has been revolutionized by the development of ... organ. But those antirejection drugs have their own side ... by scientists at Oregon Health & Science University has discovered ... effects. And the discovery means those side effects likely can ...
... , FRIDAY, Oct. 7 (HealthDay News) -- Nearly your ... play games, according to a new study. The finding ... in an attempt to win games, such as rock-paper-scissors, makes ... "Our brain functions to maximize the chance of survival ...
Cached Medicine News:Health News:Boys With Autism May Grow Faster as Babies 2Health News:Boys With Autism May Grow Faster as Babies 3Health News:Jonesing for java: Could caffeine use predict risk for cocaine abuse? 2Health News:Study uncovers why anti-rejection drugs for transplant patients cause hypertension 2
(Date:7/30/2015)... CHAGRIN FALLS, Ohio , July 30, 2015 /PRNewswire/ ... in his OMTEC® 2015 keynote address last month that ... business models in order to gain the efficiencies—and develop ... future. Dr. Barsoum,s comments were preceded by ... Tornier, avid entrepreneur and OMTEC moderator, who stressed that ...
(Date:7/30/2015)... , July 30, 2015  Growth of the U.S. ... they bring former prescription users to the OTC market. ... forecasts robust Rx-to-OTC switch activity over the next ... along with many new brands entering the market into ... the next five years (even those with low to ...
(Date:7/30/2015)... 30, 2015 P&S ... with market overview, trends, DRO analysis, market ... recent developments, competitive scenario and top competitor ... Biosensors Market Development and Demand Forecast to ... ) Explore more about global ...
Breaking Medicine Technology:Orthopaedic Surgery Reimbursement Shifts to Episode of Care 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 3Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 2Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 3Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 4Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 5
... new SONOLINE G40 ultrasound system brings,the ... an entirely new level of diagnostic ... ultra-portable,system that meets your clinical needs. ... color,Doppler and pulsed-wave Doppler capabilities,the G40 ...
... unique Acid Fast Control Slides ... with appropriate background material. Slides ... positive and negative smear. Can ... No. 353), Ziehl-Neelsen or SDLs ...
PRINCIPLE: The QC-SLIDES™ are specifically designed microscope slides intended to be part of the quality control program to monitor microbiological stains and staining techniques....
Each slide contains a gram positive control of Staphylococcus aureus ATCC ® 25923 and a gram negative control of Escherichia coli ATCC ® 25922....
Medicine Products: