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Novel drug shuts down master protein key to lymphoma
Date:8/1/2013

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The researchers found that in order for DLBCL to survive, Bcl6 needs to maintain both its shopping mall protein complex and keep the train tracks on the path toward B cell division.

To their surprise, they also found that both the complex and the train switch attach to the Bcl6 protein at the same site. "They fit into the same keyholes on Bcl6," Dr. Melnick says. "There are two identical binding sites on the protein surface."

Even better, the Bcl6 inhibitor they developed was designed to fit into that same keyhole.

"This is wonderfully serendipitous -- our drug just happens to be able to overcome both of the biological mechanisms that are key to survival of aggressive lymphoma," Dr. Melnick says, adding that the inhibitor completely eradicated DLBCL in mice in a short time, with no detectable side effects.

The team is conducting additional research toward an investigational new drug application from the federal Food and Drug Admission.


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Contact: John Rodgers
jdr2001@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

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