Navigation Links
Novel discovery by Einstein scientists could lead to much-needed kidney failure treatment
Date:3/12/2008

>When comparing biopsy samples from healthy kidneys and kidneys from people with DNP and FSGS, the researchers found evidence that the Notch pathway was active in diseased but not in healthy kidneys.

  • The researchers bred a strain of mice in which they could specifically activate the Notch pathway within podocytes. Examination revealed that the podocytes in these mice underwent programmed cell death, and the mice themselves died from end-stage renal failure.

  • After inducing glomerular disease in mice by injecting them with a toxic chemical, the researchers were able to protect the rats from developing kidney disease by injecting them with a gamma secretase inhibitorone of a class of compounds known to shut off the Notch pathway.

    An exciting aspect of this new work is the therapeutic implications, according to a Nature Medicine commentary on the Einstein study written by kidney experts from the University of Michigan Medical Center. The experts noted that gamma secretase inhibitors, like the one that protected the mice from kidney disease in this study, are already in phase 1 and 2 clinical trials for treating diseases including Alzheimers and leukemia. The Einstein findings, they wrote, provide some hope that researchers in the field of kidney disease can reverse the grim record of the last 20 years during which no new therapeutic agent has been successfully implemented for treating end-stage kidney disease.


    '/>"/>


    • Contact: Karen Gardner
    kgardner@aecom.yu.edu
    718-430-3101
    Albert Einstein College of Medicine
    Source:Eurekalert

    1

    GOOD

    Page: 1 2

    Related medicine news :

    1. Scripps Florida awarded $7.6 million grant to develop novel treatment for Parkinsons disease
    2. Affinium Pharmaceuticals, Ltd. Announces Initiation of a Phase I Clinical Trial for AFN-1252, its Novel Anti-staphylococcal Antibiotic
    3. USC researchers discover novel way to develop tumor vaccines
    4. Novel mechanism found that may boost impaired function of leukemia protein
    5. Novel method to reveal drug targets
    6. Novel link between excessive nutrient levels and insulin resistance
    7. Novel organic metal hybrids that will revolutionize materials science and chemical engineering
    8. Novel mathematical model predicts new wave of drug-resistant HIV infections in San Francisco
    9. Novel approach strips staph of virulence
    10. UCSD research team identifies novel anticancer drug from the sea
    11. Novel compound may lessen heart attack damage
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:5/25/2013)... (PRWEB) May 25, 2013 Dr. Leslie ... non-invasive procedure FDA-approved to lift skin on the neck, on ... at her practice, Medical Aesthetics. , Ultherapy is a non-surgical ... own natural healing process to lift the skin over time. ... first time, to see and then treat the deepest support ...
    (Date:5/25/2013)... York (PRWEB) May 25, 2013 Life ... which are used to detect and create a new ... test reading and are also known as biotechnology reagents. ... bioscience, diagnosis and education. , This market is driven ... reagents in the field of therapeutics, growth in research ...
    (Date:5/25/2013)... Idaho (PRWEB) May 25, 2013 A ... prevalent type of peripheral neuropathy. According to neuropathy expert ... , it is estimated that the disorder affects almost ... common complication arising from Diabetes. The high blood sugar ... Diabetes and patients suffering from it usually tend to ...
    (Date:5/25/2013)... viruses and parasites that affect both dogs and humans, ... than can result in liver or kidney failure -- ... veterinarian. These germs could be found in ... Susan Nelson, a clinical associate professor at Kansas State ... can be fatal, even with treatment," she said in ...
    (Date:5/25/2013)... The report “Global Food Encapsulation Market ... Ingredients, Shell Materials, Packaging, & Geography: Trends & ... market with analysis and forecasting of the global ... driving and restraining factors for the global food ... challenges. The market is segmented and revenue are ...
    Breaking Medicine News(10 mins):Health News:Dr. Leslie Gerstman Is Now Offering the Non-surgical Facelifting Procedure – Ultherapy – in NYC and NJ 2Health News:Life Sciences And Analytical Reagents Market - New Industry Research Report is Now Available for Pre-Order at Transparency Market Research 2Health News:Life Sciences And Analytical Reagents Market - New Industry Research Report is Now Available for Pre-Order at Transparency Market Research 3Health News:Diabetic Neuropathy treatment hits new grounds- Neuracel launches the complete natural treatment 2Health News:Hidden Dangers Dog Dog Parks 2Health News:Food Encapsulation Market to Reach $42 Billion by 2016 - New Report by MarketsandMarkets 2Health News:Food Encapsulation Market to Reach $42 Billion by 2016 - New Report by MarketsandMarkets 3
    ... in the human diet mean people today are more at ... said.Researchers at the University of Newcastle believe that changes to ... off its anti-cancer agents. ,The researchers are working ... in fighting stomach cancer. They are carrying out two trials ...
    ... an amino-acid taste receptor.Dr Charles S. Zuker, from ... of California, San Diego, reports his team's findings ... tastes — bitter, salty, sour, sweet, and umami. ... (MSG).Receptors that responded to umami have been discovered ...
    ... are associated with permutation in brain structure that appear ... conducted by researchers at the University of Iowa.// ... and 54 male control subjects, the researchers used magnetic ... They found that the volume of the anterior portion ...
    ... shun most of the dangers of developing lung cancer. There are ... are former smokers compared with those who continue to smoke.// Over ... lung cancer in the world. ,One of the authors ... study in 1950 established the smoking and lung cancer link. A ...
    ... pollutant emitted by power plants and vehicles raises the ... of dying from lung cancer or heart disease//, and ... authors contend that simply living in a major urban ... its way into your lungs when you breathe, increasing ...
    ... exercise cut the risk of diabetes by over half. ... be at increased risk of developing diabetes.// Given that ... very useful if there was some way of helping ... for the Diabetes Prevention Programme in the US have ...
    Cached Medicine News:Health News:Comprehension of taste receptor, 2
    (Date:5/23/2013)... -- More than half of women diagnosed with early ... still have excellent outcomes. To educate women, Agendia, Inc. ... sources of online consumer information about breast cancer genomic ... recently diagnosed women with information sources, to help them ... "We anticipate these innovative social media campaigns will encourage ...
    (Date:5/23/2013)... , May 23, 2013  Hologic, Inc. ... ), a leading developer, manufacturer and supplier of ... with an emphasis on serving the healthcare needs ... observational study in a U.S. clinical practice comparing ... (breast tomosynthesis) with conventional 2D mammography alone showed ...
    (Date:5/23/2013)... Md. , May 23, 2013  BioElectronics Corporation ... consumer medical devices, comments on the FDA panel meeting ... Advisory Panel Reclassification – Pulsed Shortwave Therapy Meeting was ... MD , USA.  The focus of the meeting ... the panel to focus solely on the application of ...
    Breaking Medicine Technology:Agendia Launches Social Media Campaigns to Help Breast Cancer Patients with Chemotherapy Decisions 2Agendia Launches Social Media Campaigns to Help Breast Cancer Patients with Chemotherapy Decisions 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 2First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 4BioElectronics and Pulsed Shortwave Therapy Make Progress 2
    ... UPI ), a medical device company that develops, manufactures ... reported financial results for the first quarter of fiscal 2012 ... to $4.7 million in the fiscal first quarter ended June ... quarter a year ago.  The increase reflects continued strength in ...
    ... 28, 2011 Financial Highlights ($ in millions, except per ... $110.6 , 20.2% increase Total Net Product Revenue , ... , 27.5% increaseAldurazyme BioMarin Net Product Revenue* , ... 16.6% increaseFirdapse Net Product Revenue , $3.2 , $1.1GAAP ...
    Cached Medicine Technology:Uroplasty Reports Financial Results for the First Quarter of Fiscal 2012 2Uroplasty Reports Financial Results for the First Quarter of Fiscal 2012 3Uroplasty Reports Financial Results for the First Quarter of Fiscal 2012 4Uroplasty Reports Financial Results for the First Quarter of Fiscal 2012 5Uroplasty Reports Financial Results for the First Quarter of Fiscal 2012 6Uroplasty Reports Financial Results for the First Quarter of Fiscal 2012 7Uroplasty Reports Financial Results for the First Quarter of Fiscal 2012 8BioMarin Announces Second Quarter 2011 Financial Results 2BioMarin Announces Second Quarter 2011 Financial Results 3BioMarin Announces Second Quarter 2011 Financial Results 4BioMarin Announces Second Quarter 2011 Financial Results 5BioMarin Announces Second Quarter 2011 Financial Results 6BioMarin Announces Second Quarter 2011 Financial Results 7BioMarin Announces Second Quarter 2011 Financial Results 8BioMarin Announces Second Quarter 2011 Financial Results 9BioMarin Announces Second Quarter 2011 Financial Results 10BioMarin Announces Second Quarter 2011 Financial Results 11BioMarin Announces Second Quarter 2011 Financial Results 12BioMarin Announces Second Quarter 2011 Financial Results 13
    ... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
    ... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
    ... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
    ... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
    Medicine Products: