Navigation Links
Novel cytokine protects mice from colitis
Date:8/23/2011

Inflammatory bowel disease (IBD), which affects more than 1 million patients in North America, results from an uncontrolled immune response triggered by environmental factors, such as bacteria, in people genetically predisposed to the disorder. Ulcerative colitis, or inflammation of the lining of the colon, is one such condition.

The aberrant immune response found in IBD is prompted by different cytokines small signaling proteins secreted by various cells, including immune cells that activate the immune system, causing chronic inflammation.

Now researchers led by Jess Rivera-Nieves, MD, of the Inflammatory Bowel Disease Center, Division of Gastroenterology at the University of California, San Diego School of Medicine, have discovered that expression of a newly identified human cytokine Interleukin 37 (IL-37) protects mice from colitis. The study will be published this week in Proceedings of the National Academy of Sciences (PNAS).

IL-37 is a member of the IL-1 family and functions as an inhibitor of innate inflammation and immunity. While most molecules in the IL-1 family appear to promote an inflammatory response, IL-37 modulates or downgrades inflammation.

Charles A. Dinarello, MD, from the University of Colorado, recently expressed human IL-37 in lab mice, which do not have an orthologue, or similar molecule, for this particular cytokine. Nonetheless, IL-37 works the same in both mice and humans. The mice were then fed water containing dextran sulfate sodium (DSS), a substance that induces colitis, to see whether IL-37 provided protection from intestinal inflammation.

It did. "While we still don't understand its mechanism of action, our hope is that, in the future, scientists may be able to engineer cells to overproduce IL-37 and use it to treat or control an overactive immune system in humans," said Rivera-Nieves.

That would represent a major advance in treating IBD, particularly for the 30 to 50 percent of IBD patients for whom highly effective biological therapies tumor necrosis factor inhibitors don't work, or for an even larger percentage of patients whose symptoms eventually return.


'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. FDA Approves Novel Melanoma Drug
2. St. Michaels North America first to use novel blood-cleaning procedure for kidney transplant
3. Novel DNA sequencer for MDCs systems biology
4. Novel Virus Jumped From Monkeys to Humans, Researchers Find
5. Novel combined therapy extends life, diminishes pain in brain cancer patients
6. Experiment aboard shuttle Atlantis will test novel therapy to build bone during space travel
7. Study uncovers novel genetic variation linked to increased risk of sudden cardiac arrest
8. Novel analysis method organizes genomic cancer data
9. Scientists identify a novel mechanism for evolution of highly aggressive cancers
10. CSHL structural biologists reveal novel drug binding site in NMDA receptor subunit
11. HIV-infected donors present novel source of organs for HIV-infected transplant candidates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... New studies published ... injured workers across 15 states. The outcomes examined in these studies include recovery ... care, and satisfaction with medical care. , “The goal of the studies is ...
(Date:5/25/2016)... , ... May 25, 2016 , ... CloudLIMS, joins an ... and Life Sciences Tech Solution Providers list of 2016 by CIOReview. , In a ... and Life Sciences Tech Solution Providers 2016 has been concluded with. The positioning is ...
(Date:5/25/2016)... ... May 25, 2016 , ... The World Molecular Imaging ... Molecular Imaging.” The focus of ADDMI-IG will be geared towards how using molecular ... issues. Through ADDMI-IG WMIS will provide a platform for productive discussions about the ...
(Date:5/25/2016)... ... 2016 , ... DKT International, one of the largest private ... to release their 2015 global impact data. In 2015, DKT served over 30 ... and 3.8 million unsafe abortions across 21 countries worldwide. , “We are ...
(Date:5/25/2016)... ... May 25, 2016 , ... Afrimesure specializes in ... and pharmaceutical, to food and HVAC facilities. Their knowledgeable staff also takes care ... For medical applications, Afrimesure offers a variety of MadgeTech systems available for sterilization ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 24, 2016 The innovator ... , s first dual therapy stent, introduces ... OrbusNeich, a global company specializing in the ... to include products to treat peripheral artery disease. The ... entry devices for lower limb and arteriovenous (AV) fistula ...
(Date:5/24/2016)... , May 24, 2016 Een ... verbindt, zodat zij collectief patiënten kunnen behandelen, hun kennis ... het idee achter de nieuwe en revolutionaire MDLinking App, ... de Nederlandse vaatchirurg dr. Hans Flu en oncologisch chirurg ... die inmiddels beschikbaar is, wordt op dinsdag 24 mei ...
(Date:5/23/2016)... , May 23, 2016 ... Market Size, Share, Development, Growth and Demand Forecast ... Single and Other), by Application (Drug Discovery and ... End Users (Pharmaceuticals, Life Science and Biotechnology, Academic ... P&S Market Research, the global mass spectrometry ...
Breaking Medicine Technology: