Navigation Links
Novel compound may lessen heart attack damage

DURHAM, NC A novel drug designed to lessen muscle damage from a heart attack has passed initial safety tests at the Duke Clinical Research Institute. Results of the study, available online and to be published in the February 19 issue of the journal Circulation, reflect the first time the drug has been tested in humans.

The drug, known as KAI-9803, blocks the activity of an enzyme called delta protein kinase C that triggers cell and tissue death in the aftermath of percutaneous coronary intervention, or PCI. PCI is a set of procedures including balloon angioplasty and stent placement that clear and prop open clogged coronary blood vessels that lead to a heart attack a process known as reperfusion.

Although the trial (known as DELTA-MI) was not designed to demonstrate the efficacy of KAI-9803, researchers say early data suggest it appears to be a promising compound.

Weve needed something like this for a long time, says Dr. Matthew Roe, a cardiologist at Duke and the lead investigator of the trial.

Roe says many people may not realize that the heart suffers damage at two major points in a heart attack: first, when a blockage in a coronary artery prevents blood and oxygen from getting to the heart, and then again when the patient undergoes PCI and normal blood flow is restored through reperfusion.

We may not be able to intervene in the first stage of a heart attack, but we think there may be ways to limit damage caused by reperfusion injury, he says.

Researchers randomized 154 patients who had suffered heart attacks and were eligible for PCI into either one of four dosing levels of KAI-9803 or a placebo. Patients underwent PCI with physicians injecting the drug directly into their coronary blood vessels during the procedure.

The goal of the treatment is to flood the heart damaged by the heart attack with the drug immediately before blood flow is restored and then again, immediately afterwards, says Roe. We believe that bathing the area with this novel compound may block the damaging cascade of events that are triggered specifically by delta protein kinase C when blood is restored to the heart muscle, he says.

Earlier studies in animals showed that KAI-9803 lessened damage to the heart muscle and quickly restored its pumping function.

We designed the DELTA MI trial to find out if KAI-9803 is safe for humans, and we accomplished that goal; we did not see any serious side effects, says Roe. We also found, however, many promising signs of beneficial drug activity such as lessened damage to the heart muscle and improvement in electrical conductivity in the heart that corresponded to restoration of blood flow to the heart muscle. As a result, we feel this drug has the potential to be helpful in reducing the impact of a heart attack in humans.


Contact: Michelle Gailiun
Duke University Medical Center

Related medicine news :

1. Novel molecules developed at UB can boost vaccine potency
2. Novel small molecule therapy shows benefit for anemic patients via hydration of red blood cells
3. Novel vaccine concept developed by scientists at the Wistar Institute
4. Tibotec Pharmaceuticals a Respectful Partner to HIV Community in Pricing of Novel New HIV NNRTI, INTELENCE
5. Millennium and Harvard Medical School Sign Cooperative Agreement for Research in Novel Field of Cancer Biology
6. Statement by AARP CEO Bill Novelli on President Bushs State of the Union
7. New method enables design, production of extremely novel drugs
8. Nerites Receives NIH Grant to Study Novel Treatment for Preventing Dangerous Bacterial Infections on Urinary Stents and Catheters
9. Speedy Procedures Demonstrate Excitement and Continued Interest in Novel Multi-Electrode Ablation System
10. Novel anticancer strategy moves from laboratory to clinic
11. FDA approves Bystolic, a novel beta blocker
Post Your Comments:
(Date:11/30/2015)... , ... November 30, 2015 , ... Stress, anxiety, illness, ... a parent worry about possible tumors? , Heather Spader, MD, a new pediatric neurosurgeon ... are common, some signs might point to tumors. , “Bad headaches that ...
(Date:11/30/2015)... Minneapolis, MN (PRWEB) , ... November 30, 2015 ... ... launched at . The directory is specialized and only includes chiropractic ... is to find a competent and trustworthy alternative health practitioner when back pain ...
(Date:11/30/2015)... ... , ... The world of hair transplants and restoration is filled with methods ... procedures have been in use for many years and are among the most commonly ... has utilized many of these methods over the years, he also keeps an eye ...
(Date:11/30/2015)... ... 2015 , ... In an effort to make it easier ... information provided directly from top experts in mesothelioma, in 2016 the International ... major cities: Houston, San Francisco, and Chicago. , “For many mesothelioma patients ...
(Date:11/30/2015)... ... November 30, 2015 , ... According to an ... made a brave but slightly unusual choice to show her Instagram followers that the ... form may have been pre-mature. Saying that she didn’t “want to mislead any mommy's ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... TERRACE, Wash. and ST. LOUIS ... and Express Scripts (NASDAQ: ESRX ) today announced ... agreement. The partnership, which began in 1999, will now ... --> --> After evaluating pharmacy benefit ... Premera concluded that Express Scripts continues to offer the ...
(Date:11/30/2015)... NASHUA, N.H. , Nov. 30, 2015 /PRNewswire/ ... today that it will feature its latest solutions ... the early identification of cancer at the Radiological ... in Chicago from November ... showcase recent product advances including iReveal®, an automated ...
(Date:11/30/2015)... , Nov. 30, 2015 NHS ... further 20 TrueBeam™ machines from Varian Medical Systems ... ongoing program to replace older machines and institute ... the UK,s public hospitals. The order, placed in ... 50 licenses for Varian,s RapidArc® and Eclipse™ software ...
Breaking Medicine Technology: