Navigation Links
Novel compound keeps Parkinson's symptoms at bay in mice
Date:2/12/2014

Scientists report that they have developed a novel compound that appears to protect mice against developing movement problems associated with Parkinson's disease (PD). The research, which could one day in the future translate into a therapy that could halt the progression of PD and thereby prevent the symptoms of the disease, appears in ACS' Journal of Medicinal Chemistry.

Onyou Hwang, Ki Duk Park and colleagues explain that PD, which affects an estimated 4 million to 10 million people worldwide, is a progressive movement disorder with no known cure. It often starts with slight tremors and gets worse over time. Muscles go stiff. Walking becomes difficult. Speech is slurred. No one knows for certain what causes the disease, but research has shown that it's linked with the loss of nerve cells in the brain that secrete dopamine, a chemical that is involved in movement and emotion. To find a potential new therapy for PD, the research team searched for a way to shield these brain cells.

They made 56 compounds and tested them to see which ones boosted the production of proteins that protect dopamine-releasing neurons from damage. Of those, one, which they call "12g," proved to be the most active. Interestingly, it protected mice from developing PD-like symptoms in one laboratory test. "Taken together, 12g was found to effectively prevent the motor deficits that are associated with PD," they say.

The authors acknowledge funding from the Korea Institute of Science and Technology, the Korea Health Technology R&D Project, the Ministry of Health and Welfare, the Korea Research Council of Fundamental Science and Technology and the National Research Foundation of Korea.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related medicine news :

1. New company to develop novel gene therapies
2. Novel technique increases detection rate in screening mammography
3. Researchers find novel approach for controlling deadly C. difficile infections
4. Novel genes determine division of labor in insect societies
5. Novel biomarker approach suggests new avenues to improve schizophrenia disease management
6. Development of a novel dual JAK/Src kinase inhibitor
7. Jesus Was Not Born On December 25th - Controversial New Novel Tells Compelling Story About His Birth, Life and Death
8. Fatigue, a common side effect of breast cancer treatment, evaluated in novel patient study
9. Novel drug regimen can improve stem cell transplantation outcomes
10. NIST calibration tools to encourage use of novel medical imaging technique
11. Successful repair of bone defects using a novel tissue engineered bone graft
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... Fla. (PRWEB) , ... June 24, 2016 , ... Global ... Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition ... Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this year’s ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening ... Talker Award, an essay contest in which patients and their families pay tribute to ... at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this ...
(Date:6/24/2016)... ... 2016 , ... Strategic Capital Partners, LLC (SCP) in concert ... capital for emerging technology companies. SCP has delivered investment events and professional ... than a million dollars of capital investment for five companies. The ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... Market by Type (Standard Pen Needles, Safety Pen Needles), ... (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) ... MarketsandMarkets, This report studies the market for the forecast ... to reach USD 2.81 Billion by 2021 from USD ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
(Date:6/23/2016)...  MedSource announced today that it has selected ... of choice.  This latest decision demonstrates MedSource,s commitment ... clients by offering a state-of-the-art electronic data capture ... as the EDC platform of choice in exchange ... has long been a preferred EDC platform by ...
Breaking Medicine Technology: