Navigation Links
Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment
Date:4/9/2012

sh serve as an excellent model for many cancers, including leukemia, because the zebrafish and human genomes and immune systems share many similarities, making them easy targets for genetic modification to mimic human cancers," said Dr. Trede, the study's senior author.

Dr. Trede's team used a line of zebrafish they had previously created, in which immature T-cells were fluorescently labeled so they effectively "glowed" when present, to help identify whether any test compound eliminated those cells while ensuring that they did not affect any other cell types or compromise the overall health of the fish. They screened 26,400 molecules and identified the novel molecular compound Lenaldekar (LDK) as effective in eliminating immature zebrafish T-cells and targeting human T-ALL cell lines without causing major toxicity to other cell types.

After confirming LDK's effectiveness in vitro, the investigators then tested its efficacy in zebrafish and mouse models of human T-ALL. After a 14-day treatment period, researchers found that more than 60 percent of all zebrafish treated with LDK maintained long-term remission (more than nine months), while 100 percent of zebrafish treated with the control died by day 40. Similarly, in the mouse model, treatment with LDK significantly slowed disease progression without toxicity.

The team then examined LDK's effectiveness in treating cells taken directly from patients with other leukemias, namely chronic myeloid leukemia (CML) and B-cell ALL (B-ALL), including those resistant to current therapies. After testing a number of patient samples, researchers found that LDK was active against the vast majority of primary leukemia samples, demonstrating its effectiveness beyond T-ALL.

In addition to demonstrating LDK's efficacy, investigators also discovered that the compound works differently from current leukemia treatments because it inhibits both an important signaling pathway that promotes the s
'/>"/>

Contact: Claire Gwayi-Chore
cgwayi-chore@hematology.org
202-776-0544
American Society of Hematology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Novel drug in pill form safer than standard approach to treat blocked lung blood vessels
2. Novel mouse model for autism yields clues to a 50-year-old mystery
3. Unprecedented academic-industry collaboration seeks new drugs and novel treatments for autism
4. Novel plastics and textiles from waste with the use of microbes
5. UC San Diego among first in nation to treat brain cancer with novel viral vector
6. Students at Western University develop a novel way to teach interdisciplinary care
7. UH Case Medical Center publishes study on novel treatment for skin lymphoma
8. Mass. General researchers find novel way to prevent drug-induced liver injury
9. Rutgers, Massachusetts General investigators find novel way to prevent drug-induced liver injury
10. NIH scientists identify novel approach to view inner workings of viruses
11. Novel Stem Cell Treatment May Hold Promise for Type 1 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... August 29, 2015 , ... ProDrop Particles includes over 40 ... contains 15 seconds of unique footage that users can shrink and stretch in the ... and more. Users can customize color, brightness, scale, speed, range, and flare attributes with ...
(Date:8/28/2015)... ... August 29, 2015 , ... Rio Salado College ... the student experience as part of the EDUCAUSE - Next Generation Learning Challenges 2015 ... This is the third Breakthrough Models Incubator hosted by EDUCAUSE and NGLC, ...
(Date:8/28/2015)... ... , ... An article published August 19th by the LA Times ... to open a pizzeria in Westchester. Mr. LaRocco was aware from opening prior pizza ... the current process, having already gone on for over a year, is taking much ...
(Date:8/28/2015)... ... 28, 2015 , ... The 6th Annual Survivor in the City, Chicago ... yet another accolade to its cadre of widespread support—an official letter of support and ... of the medical community and the University of Illinois at Chicago’s Department of Neurosurgery, ...
(Date:8/28/2015)... ... 28, 2015 , ... Altima Technologies, Inc., the maker of ... center assets and audio-video devices, recently released Visio Stencils for the following product ... Gen9, EMC VNX Series , Super Micro Computer SuperStorage, Hitachi Data Systems Virtual ...
Breaking Medicine News(10 mins):Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 3Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 4Health News:Article on Building Approval Process for LA Business Highlights the Need for a Bridge Between Businesses and City Officials, says Fire Protection Group Inc. 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 3Health News:Altima Updates NetZoom™ Visio® Stencil Library for Cisco, HP, and EMC Devices 2Health News:Altima Updates NetZoom™ Visio® Stencil Library for Cisco, HP, and EMC Devices 3
... Online Community and Collaboration Platform is Gaining ... Significant Usage in the ... GoLightly, Inc., a market,leader in delivering effective and ... software solutions for corporations and,membership organizations, is pleased ...
... LDG ) today reported preliminary total retail drug,store sales for the five-week and nine-week periods ended April 3, 2008., , ... Periods ended April 3, 2008, ... Month Quarter to Date (Dollars in millions) ... (9 weeks), Total retail drug store sales ...
... Inc. (Nasdaq: LMAT ) today announced the ... American Sales, to pursue other,business opportunities and the ... American Sales., Mr. Linden has approximately six ... joined LeMaitre Vascular in July 2002 as a ...
... July,6, 2006, Current Technology Corporation (the "Company") announced that,Keith ... Chief Executive,Officer, for nominal consideration, options ("Options") to purchase ... personal holdings, under the,following terms and conditions:, ... option -- 3,000,000; ii) exercise price ...
... on Saturday, April 12th at the ... Helen Mills Theatre in NYC, NEW YORK, ... a benefit concert on Saturday,April 12th at the Helen Mills Theatre in ... One,s Personal: A,Concert to Stop ACD," is being hosted by the 3 ...
... males who bring them pebbles to build egg nests. ... flowers guarded by larger males. , New research ... resources will still attempt to trade sexual currency for ... of Michigan School of Public Health. , The exchange ...
Cached Medicine News:Health News:Healthcare Sector Benefits from Online Community 2Health News:Longs Reports Preliminary March Retail Drug Store Sales 2Health News:LeMaitre Vascular Announces Changes to Its Executive Management Team 2Health News:Keith Denner Extends Current Technology's Chairman and CEO Options 2Health News:Keith Denner Extends Current Technology's Chairman and CEO Options 3Health News:Kristin Chenoweth to Perform Benefit Concert for 3 Angels Memorial Fund titled, 'Kristin Chenoweth, This One's Personal: A Concert to Stop ACD' 2Health News:Kristin Chenoweth to Perform Benefit Concert for 3 Angels Memorial Fund titled, 'Kristin Chenoweth, This One's Personal: A Concert to Stop ACD' 3Health News:Just like penguins and other primates, people trade sex for resources 2
(Date:8/28/2015)... , August 28, 2015 Insights- ... seamlessly connects people, technologies and care protoc ols across ... and the cost of healthcare delivery   ... presence at  ESC Congress 2015 , where the company is ... EchoNavigator and IntelliSpace Cardiovascular, that connect people and technology with ...
(Date:8/27/2015)... Aug. 27, 2015 Biosimilars are not ... the U.S. Food and Drug Administration (FDA) for ... in its draft guidance issued today. The FDA,s ... proposes distinguishable names, calling for biological products to ... suffix. This proposal reflects the agency,s thinking that ...
(Date:8/27/2015)... Women Grow , the fastest-growing professional networking organization for women ... Cannabis World Congress & Business Exposition (CWCBExpo) in ... sessions. CWCBExpo in LA will take place September 16-18, 2015 ... in Los Angeles, CA , and is ... marijuana industry. The Women Grow tracks at ...
Breaking Medicine Technology:Philips Showcases New Integrated Cardiology Solutions to Advance Minimally Invasive Procedures at ESC Congress 2015 2Philips Showcases New Integrated Cardiology Solutions to Advance Minimally Invasive Procedures at ESC Congress 2015 3Philips Showcases New Integrated Cardiology Solutions to Advance Minimally Invasive Procedures at ESC Congress 2015 4Biologics Prescribers Collaborative (BPC) Statement on FDA Draft Guidance entitled "Nonproprietary Naming of Biological Products" 2Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 2Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 3Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 4
... is money, and time that is wasted looking for the right ... mobile and HTML5 app released by Providian Medical Equipment LLC is ... money. With just a few quick and easy steps, the app ... machines based on their individual needs. The app allows a user ...
... 2011 Unilife Corporation ("Unilife" or the ... announced strategic additions to its management team. These senior ... the Unifill ® ready-to-fill (prefilled) syringe to a ... accelerate the commercialization of other pipeline devices within the ...
Cached Medicine Technology:Providian Medical Launches New Tool to Make Finding the Right Ultrasound Machine Easier Than Ever 2Unilife Expands Management Team to Support Business Growth 2Unilife Expands Management Team to Support Business Growth 3Unilife Expands Management Team to Support Business Growth 4Unilife Expands Management Team to Support Business Growth 5Unilife Expands Management Team to Support Business Growth 6
Distinct male and female designs for proper anatomical fit. Hip and pelvic components sized independently. Rigid posterior tongue minimizes pelvic rotation. Available in black or white plastic. Aggre...
Modular hip abduction system designed to provide superior fit, adjustability and functionality for optimum patient stability, comfort and compliance...
... Stabilizer Abduction and rotation ... revisions and fractures. Preset ... with adjustable flexion and ... Adjustabelt back panel. Available ...
... contact casting for the treatment of ... plantar surface of the foot. Other ... plantar fasciitis or other foot conditions ... even distribution of body weight on ...
Medicine Products: