Navigation Links
Novel combined therapy extends life, diminishes pain in brain cancer patients
Date:7/14/2011

Approximately five to ten percent of patients with primary or metastatic cancer suffer from devastating neurological complications such as headaches, seizures, confusion, difficulty swallowing and visual disturbances. These deficits are caused by a life-threatening form of brain invasion from cancer called neoplastic meningitis. Santosh Kesari, MD, PhD, at the University of California, San Diego School of Medicine and colleagues have utilized a novel combined technique to treat cancer patients by bathing the brain in chemotherapy and relieving pressure from spinal fluid build-up (hydrocephalus). The results of this multicenter study are described in Journal of Neurosurgery, now available online.

"What we have developed is a single intervention to treat both neoplastic meningitis and hydrocephalus," said Kesari, chief of neuro-oncology at UC San Diego Moores Cancer Center and associate professor of neurosciences at the UCSD School of Medicine. "Cancer should be fought by every method available, and this is an aggressive option that can dramatically improve function and survival for select patients."

When cancer cells infiltrate the spaces within the brain, the cells prevent the flow and absorption of spinal fluid. This blockage causes increased pressure and fluid accumulation. By inserting an externally operated "off-on" valve along with an Ommaya reservoir a small plastic device used to carry medicine to fluid in the brain and spinal cord and shunt, doctors can both deliver chemotherapy directly to the brain's surfaces and drain excess fluids to the abdomen via a thin internal catheter.

"This dual-purpose technique allows for both diversion of excess spinal fluid and treatment of the underlying cancer," said Bob Carter, MD, PhD, UCSD chief of neurosurgery who performs the technique for patients at Moores Cancer Center. "When brain tumor care is coordinated by a multidisciplinary team such as ours, the results can significantly improve quality of life."

Kesari, who performed the original research on this technique at Harvard Medical School and Brigham and Women's Hospital, said that further studies need to be done to better understand and optimize this combined approach. Kesari and Carter are planning larger, prospective clinical studies to further optimize outcomes in metastatic brain cancer patients.


'/>"/>

Contact: Kim Edwards
kedwards@ucsd.edu
619-543-2707
University of California - San Diego
Source:Eurekalert  

Related medicine news :

1. Experiment aboard shuttle Atlantis will test novel therapy to build bone during space travel
2. Study uncovers novel genetic variation linked to increased risk of sudden cardiac arrest
3. Novel analysis method organizes genomic cancer data
4. Scientists identify a novel mechanism for evolution of highly aggressive cancers
5. CSHL structural biologists reveal novel drug binding site in NMDA receptor subunit
6. HIV-infected donors present novel source of organs for HIV-infected transplant candidates
7. Study identifies novel role for a protein that could lead to new treatments for rheumatoid arthritis
8. GEN reports on novel noninvasive tests for early cancer detection
9. Novel program is saving newborns’ lives in developing countries
10. Novel Hepatitis C Drug Holds Promise: FDA
11. A potential novel drug-target for colorectal cancer treatment comes from the brain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel combined therapy extends life, diminishes pain in brain cancer patients
(Date:6/26/2016)... ... ... PawPaws brand pet supplements owned by Whole Health Supply is ... of felines. The formula is all-natural and is made from Chinese herbs that have ... Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root Extract ...
(Date:6/25/2016)... Washington, D.C. (PRWEB) , ... June 25, 2016 ... ... will discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June ... share their work on several important health care topics including advance care planning, ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... people are unfamiliar with. The article goes on to state that individuals are now ... of these less common operations such as calf and cheek reduction. The Los Angeles ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: DHRM ) ... medical devices and wearable sleep respiratory products in ... with Hongyuan Supply Chain Management Co., Ltd. (hereinafter referred ... to develop Dehaier,s new Internet medical technology business. ... Hongyuan Supply Chain,s sales platform to reach Dehaier,s dealers ...
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
Breaking Medicine Technology: