Navigation Links
Novel combined therapy extends life, diminishes pain in brain cancer patients
Date:7/14/2011

Approximately five to ten percent of patients with primary or metastatic cancer suffer from devastating neurological complications such as headaches, seizures, confusion, difficulty swallowing and visual disturbances. These deficits are caused by a life-threatening form of brain invasion from cancer called neoplastic meningitis. Santosh Kesari, MD, PhD, at the University of California, San Diego School of Medicine and colleagues have utilized a novel combined technique to treat cancer patients by bathing the brain in chemotherapy and relieving pressure from spinal fluid build-up (hydrocephalus). The results of this multicenter study are described in Journal of Neurosurgery, now available online.

"What we have developed is a single intervention to treat both neoplastic meningitis and hydrocephalus," said Kesari, chief of neuro-oncology at UC San Diego Moores Cancer Center and associate professor of neurosciences at the UCSD School of Medicine. "Cancer should be fought by every method available, and this is an aggressive option that can dramatically improve function and survival for select patients."

When cancer cells infiltrate the spaces within the brain, the cells prevent the flow and absorption of spinal fluid. This blockage causes increased pressure and fluid accumulation. By inserting an externally operated "off-on" valve along with an Ommaya reservoir a small plastic device used to carry medicine to fluid in the brain and spinal cord and shunt, doctors can both deliver chemotherapy directly to the brain's surfaces and drain excess fluids to the abdomen via a thin internal catheter.

"This dual-purpose technique allows for both diversion of excess spinal fluid and treatment of the underlying cancer," said Bob Carter, MD, PhD, UCSD chief of neurosurgery who performs the technique for patients at Moores Cancer Center. "When brain tumor care is coordinated by a multidisciplinary team such as ours, the results can significantly improve quality of life."

Kesari, who performed the original research on this technique at Harvard Medical School and Brigham and Women's Hospital, said that further studies need to be done to better understand and optimize this combined approach. Kesari and Carter are planning larger, prospective clinical studies to further optimize outcomes in metastatic brain cancer patients.


'/>"/>

Contact: Kim Edwards
kedwards@ucsd.edu
619-543-2707
University of California - San Diego
Source:Eurekalert  

Related medicine news :

1. Experiment aboard shuttle Atlantis will test novel therapy to build bone during space travel
2. Study uncovers novel genetic variation linked to increased risk of sudden cardiac arrest
3. Novel analysis method organizes genomic cancer data
4. Scientists identify a novel mechanism for evolution of highly aggressive cancers
5. CSHL structural biologists reveal novel drug binding site in NMDA receptor subunit
6. HIV-infected donors present novel source of organs for HIV-infected transplant candidates
7. Study identifies novel role for a protein that could lead to new treatments for rheumatoid arthritis
8. GEN reports on novel noninvasive tests for early cancer detection
9. Novel program is saving newborns’ lives in developing countries
10. Novel Hepatitis C Drug Holds Promise: FDA
11. A potential novel drug-target for colorectal cancer treatment comes from the brain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel combined therapy extends life, diminishes pain in brain cancer patients
(Date:4/25/2017)... ... April 25, 2017 , ... Buyers and sellers in the ... dispensaries and head shops –can’t help but be heartened by the industry’s current surge. ... odor aptly described as “skunk smell.” At last they can simply, safely and ...
(Date:4/25/2017)... ... April 25, 2017 , ... There is no better place in South ... special report in the May issue of Consumer Reports focused on heart health. ... results achieved during and after coronary bypass and aortic valve replacement procedures. , ...
(Date:4/24/2017)... ... April 24, 2017 , ... LG ... Your Own Device (BYOD) capabilities at Telehealth 2.0, the American Telemedicine Association’s national ... which pairs medical devices with a pre-programmed tablet in a remarkably easy-to-use kit ...
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... As part ... Museum today to honor the victims of the Holocaust and Nazi persecution, Center ... at Hadamar and Auschwitz on its CMATH Champions trip to Germany and Poland next ...
(Date:4/24/2017)... ... ... The California Dental Association Foundation’s two-day volunteer dental clinic, CDA Cares ... April 22-23 event at the San Mateo Event Center. , In addition to ... Cares educates the public and policymakers about the importance of good oral health and ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 2017 The Global Effective Microorganisms (EM) ... report has covered and analysed the potential of Global Effective ... size, shares and growth factors. The report identifies and analyses ... in the global market. ... Browse 152 Tables and Figures, 6 Major Company Profiles, spread ...
(Date:4/19/2017)... , April 19, 2017 ... an immune response in pets such as canine, ... are of various types such as Attenuated Live ... Vaccines, DNA Vaccines and Recombinant Vaccines. Attenuated live ... virus or bacteria, which have been weakend under ...
(Date:4/19/2017)... , April 19, 2017  Novartis today ... the National Heart, Lung, and Blood Institute (NHLBI) ... that 58% of patients with treatment-naïve severe aplastic ... when treated with eltrombopag at the initiation of ... The study evaluated three sequential treatment groups, or ...
Breaking Medicine Technology: