Navigation Links
Novel combined therapy extends life, diminishes pain in brain cancer patients

Approximately five to ten percent of patients with primary or metastatic cancer suffer from devastating neurological complications such as headaches, seizures, confusion, difficulty swallowing and visual disturbances. These deficits are caused by a life-threatening form of brain invasion from cancer called neoplastic meningitis. Santosh Kesari, MD, PhD, at the University of California, San Diego School of Medicine and colleagues have utilized a novel combined technique to treat cancer patients by bathing the brain in chemotherapy and relieving pressure from spinal fluid build-up (hydrocephalus). The results of this multicenter study are described in Journal of Neurosurgery, now available online.

"What we have developed is a single intervention to treat both neoplastic meningitis and hydrocephalus," said Kesari, chief of neuro-oncology at UC San Diego Moores Cancer Center and associate professor of neurosciences at the UCSD School of Medicine. "Cancer should be fought by every method available, and this is an aggressive option that can dramatically improve function and survival for select patients."

When cancer cells infiltrate the spaces within the brain, the cells prevent the flow and absorption of spinal fluid. This blockage causes increased pressure and fluid accumulation. By inserting an externally operated "off-on" valve along with an Ommaya reservoir a small plastic device used to carry medicine to fluid in the brain and spinal cord and shunt, doctors can both deliver chemotherapy directly to the brain's surfaces and drain excess fluids to the abdomen via a thin internal catheter.

"This dual-purpose technique allows for both diversion of excess spinal fluid and treatment of the underlying cancer," said Bob Carter, MD, PhD, UCSD chief of neurosurgery who performs the technique for patients at Moores Cancer Center. "When brain tumor care is coordinated by a multidisciplinary team such as ours, the results can significantly improve quality of life."

Kesari, who performed the original research on this technique at Harvard Medical School and Brigham and Women's Hospital, said that further studies need to be done to better understand and optimize this combined approach. Kesari and Carter are planning larger, prospective clinical studies to further optimize outcomes in metastatic brain cancer patients.


Contact: Kim Edwards
University of California - San Diego

Related medicine news :

1. Experiment aboard shuttle Atlantis will test novel therapy to build bone during space travel
2. Study uncovers novel genetic variation linked to increased risk of sudden cardiac arrest
3. Novel analysis method organizes genomic cancer data
4. Scientists identify a novel mechanism for evolution of highly aggressive cancers
5. CSHL structural biologists reveal novel drug binding site in NMDA receptor subunit
6. HIV-infected donors present novel source of organs for HIV-infected transplant candidates
7. Study identifies novel role for a protein that could lead to new treatments for rheumatoid arthritis
8. GEN reports on novel noninvasive tests for early cancer detection
9. Novel program is saving newborns’ lives in developing countries
10. Novel Hepatitis C Drug Holds Promise: FDA
11. A potential novel drug-target for colorectal cancer treatment comes from the brain
Post Your Comments:
Related Image:
Novel combined therapy extends life, diminishes pain in brain cancer patients
(Date:11/30/2015)... ... November 30, 2015 , ... World Patent Marketing ... Swappables, a household invention that provides an economical and easy way of gaining ... is growing at 2.6%," says Scott Cooper, CEO and Creative Director of World ...
(Date:11/30/2015)... ... 30, 2015 , ... CTI Group (Holdings) Inc. (OTC:CTIG), a ... communication analytics, announced today that their Proteus® VoIP QMS solution now supports Skype ... Proteus® VoIP QMS (Quality Management System) does this by collecting the ...
(Date:11/29/2015)... Orion, Clarkston, Metamora, Michigan (PRWEB) , ... ... ... Women's Excellence is once again accredited by the American Institute of Ultrasound ... process that allows practices to demonstrate that they meet or exceed nationally ...
(Date:11/29/2015)... ... ... The Cyber Monday deal is a deep 40% or more discount on every item on ... the skin care lover in your circle. Each Christmas, Sublime Beauty offers a special ... serums are staples: Collagen, Retinol and Hyaluronic Serums. , Stocking stuffers like Skin Brushes, natural ...
(Date:11/29/2015)... ... November 29, 2015 , ... Khanna Vision Institute based in Los Angeles, announced ... November 25th 2015. Peer Certification by the Board is done so the public knows ... is first obtained after the completion of three years of training or Residency in ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... HANOVER, N.J. , Nov. 30, 2015  Novartis ... portfolio at the 57 th American Society of ... leukemias, lymphomas and myelomas as well as supportive care, ... in addition to personalized cell therapies. The ASH Annual ... Orlando, Florida . Novartis Oncology . ...
(Date:11/30/2015)... , Belgium , Nov. 30, 2015 ... sciences company focused on developing blood-based diagnostic tests for a ... the Company will present at the LD Micro Conference, which ... Los Angeles, CA. Attending from VolitionRx will be ... Scott Powell , Vice President of Investor Relations. ...
(Date:11/30/2015)... , Nov. 30, 2015  Precision Image ... services, is pleased to announce a dramatic expansion ... imaging services. Building on its ISO-9001:2008 certification for ... implemented comprehensive Core Lab protocols and procedures. This ... of research activities.  Their Core Lab services include ...
Breaking Medicine Technology: