Navigation Links
Novel cancer vaccine holds promise against ovarian cancer, mesothelioma
Date:3/5/2014

ovarian cancer and pancreatic cancer to a protein from the tuberculosis bacteria that stimulates the activity of dendritic and other immune cells. In this system, the dendritic cells are activated and targeted against tumor cells while remaining inside the patient's body.

In the experiments described in the paper, the MGH team confirmed that their mesothelin-targeting fusion protein binds to mesothelin on either ovarian cancer or mesothelioma cells, activates dendritic cells, and enhances the cells' processing and presentation of several different tumor antigens, inducing a number of T-cell-based immune responses. In mouse models of both tumors, treatment with the fusion protein significantly slowed tumor growth and extended survival, probably through the activity of cytotoxic CD8 T cells.

"Many patients with advanced cancers don't have enough functioning immune cells to be harvested to make a vaccine, but our protein can be made in unlimited amounts to work with the immune cells patients have remaining," explains study co-author Jeffrey Gelfand, MD, senior scientist at the Vaccine and Immunotherapy Center. "We have created a potentially much less expensive approach to making a therapeutic cancer vaccine that, while targeting a single tumor antigen, generates an immune response against multiple antigens. Now if we can combine this with newly-described ways to remove the immune system's "brakes" regulatory functions that normally suppress persistent T-cell activity the combination could dramatically enhance cancer immunotherapy."

Poznansky adds that the tumors that might be treated with the mesothelin-targeting vaccine ovarian cancer, pancreatic cancer and mesothelioma all have poor survival rates. "Immunotherapy is generally nontoxic, so this vaccine has the potential of safely extending survival and reducing the effects of these tumors, possibly even cutting the risk of recurrence. We believe that this approach could ultimately be
'/>"/>

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. A novel treatment may reduce myocardial infarction size
2. A new target for cancer and diabetes: A novel role for the adaptor protein p66shc in regulating glucose metabolism
3. Novel compound keeps Parkinsons symptoms at bay in mice
4. New company to develop novel gene therapies
5. Novel technique increases detection rate in screening mammography
6. Researchers find novel approach for controlling deadly C. difficile infections
7. Novel genes determine division of labor in insect societies
8. Novel biomarker approach suggests new avenues to improve schizophrenia disease management
9. Development of a novel dual JAK/Src kinase inhibitor
10. Jesus Was Not Born On December 25th - Controversial New Novel Tells Compelling Story About His Birth, Life and Death
11. Fatigue, a common side effect of breast cancer treatment, evaluated in novel patient study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel cancer vaccine holds promise against ovarian cancer, mesothelioma
(Date:8/19/2014)... Horizon Blue Cross Blue Shield of New Jersey ... again teaming up during The Barclays at The Ridgewood ... Challenge, and Horizon BCBSNJ will be getting spectators into the ... their own. , Horizon BCBSNJ, the official health care sponsor ... donation to the New Jersey Golf Foundation, an organization that ...
(Date:8/19/2014)... NY (PRWEB) August 19, 2014 ... were named the winner of the 2014 Independent ... took home the first place position in “Product ... marketplace specially-formatted eyeliner, which also includes a lash ... black color, plus lash-boosting technology. , ...
(Date:8/19/2014)... August 19, 2014 Following the completion of ... Hyatt Tampa Bay is proud to debut the highly ... project included a full revamp of all public spaces to ... rooms and suites, an all-new dining experience at 1823 Kitchen ... lobby. , With the introduction of 1823 Kitchen and Bar, ...
(Date:8/19/2014)... Philadelphia, PA, August 19, 2014 Warfarin, the ... competition from new options in the anticoagulant drug ... study documents the rapid adoption of these novel ... NOACs accounted for 62% of all new anticoagulant ... drug costs. Findings are published in The ...
(Date:8/19/2014)... Title Boxing Club Cool Springs is now open. ... away prizes – including an entire year's membership. Sweepstakes ... and click on the “Hit It Hard” Sweepstakes. Once ... enters, you will receive an additional chance to win. ... take advantage of the “Pre-Opening Special” which Includes a ...
Breaking Medicine News(10 mins):Health News:Horizon Blue Cross Blue Shield of New Jersey Pairs up with PGA TOUR Pro Morgan Hoffmann for Walking Challenge During The Barclays for Charity and to Promote Good Health 2Health News:Horizon Blue Cross Blue Shield of New Jersey Pairs up with PGA TOUR Pro Morgan Hoffmann for Walking Challenge During The Barclays for Charity and to Promote Good Health 3Health News:Horizon Blue Cross Blue Shield of New Jersey Pairs up with PGA TOUR Pro Morgan Hoffmann for Walking Challenge During The Barclays for Charity and to Promote Good Health 4Health News:GrandeLINER™ Wins Independent Cosmetics Manufacturers & Distributors Award 2Health News:GrandeLINER™ Wins Independent Cosmetics Manufacturers & Distributors Award 3Health News:Grand Hyatt Tampa Bay Hotel Unveils the Finishing Touches of Its $20 Million Makeover 2Health News:Novel oral anticoagulant prescriptions soar, but at a high cost 2Health News:Novel oral anticoagulant prescriptions soar, but at a high cost 3Health News:Title Boxing Club Cool Springs is Officially Open 2
... CBM ) reports fourth quarter and full year 2008 results ... , Sales increased 0.8% compared ... the impact of foreign currency. Reported sales declined by 6.6% ... Adjusted EBITDA (see attached table) was $10.7 ...
... New Product Development, Marketing and InnovationBEDFORD, Mass., Feb. ... and produced by Insulet Corporation (Nasdaq: ... for the prestigious 2009 Edison Best New Product ... accolades honoring excellence in new product development, marketing, ...
... to better diagnosis, treatment for heart patients , , WEDNESDAY, ... called contrast echocardiography had a significant impact on the ... a new study found. , Echocardiography bounces sound waves ... the moving heart. If that image isn,t clear enough, ...
... than $1000. , ... Eagan, MN (Vocus) February 11, 2009 -- Employees ... United Way of Northeastern Minnesota. A company cookbook was created and ... Iowa. More than 200 cookbooks were sold. , , , ...
... Doctors with Plastic Surgery Services of Fredericksburg ... area to offer LATISSE(TM), the new FDA-approved prescription ... darker, fuller and longer. LATISSE,s maker, Allergan, ... BOTOX(R) and Juvederm(TM). The active ingredient in LATISSE(TM) ...
... doctors at high-volume hospitals do best, study finds , , ... a person surviving a heart attack roughly double ... and facility experienced in the use of angioplasty and ... percutaneous coronary interevention (PCI), which uses angioplasty and a ...
Cached Medicine News:Health News:Cambrex Reports Fourth Quarter and Full Year 2008 Results 2Health News:Cambrex Reports Fourth Quarter and Full Year 2008 Results 3Health News:Cambrex Reports Fourth Quarter and Full Year 2008 Results 4Health News:Cambrex Reports Fourth Quarter and Full Year 2008 Results 5Health News:Cambrex Reports Fourth Quarter and Full Year 2008 Results 6Health News:Cambrex Reports Fourth Quarter and Full Year 2008 Results 7Health News:Cambrex Reports Fourth Quarter and Full Year 2008 Results 8Health News:Cambrex Reports Fourth Quarter and Full Year 2008 Results 9Health News:Cambrex Reports Fourth Quarter and Full Year 2008 Results 10Health News:Cambrex Reports Fourth Quarter and Full Year 2008 Results 11Health News:Cambrex Reports Fourth Quarter and Full Year 2008 Results 12Health News:Cambrex Reports Fourth Quarter and Full Year 2008 Results 13Health News:Cambrex Reports Fourth Quarter and Full Year 2008 Results 14Health News:Cambrex Reports Fourth Quarter and Full Year 2008 Results 15Health News:OmniPod(R) Insulin Management System Selected as a Finalist for the 2009 Edison Best New Product Awards(TM) 2Health News:OmniPod(R) Insulin Management System Selected as a Finalist for the 2009 Edison Best New Product Awards(TM) 3Health News:Study Brings Value of Echocardiography Into Focus 2Health News:Company Cookbook Proceeds to Benefit United Way of Northeastern Minnesota 2Health News:Long and Lovely Lashes by LATISSE(TM) Now Available Through Plastic Surgery Services of Fredericksburg 2Health News:Experience Brings Better Angioplasty Outcomes 2
(Date:8/18/2014)... , August 19, 2014 Elbit ... EMITF ) announced today that Elbit Medical Technologies ... Company in which it holds approximately 86% of the ... Cell Ltd., in which Elbit Medical holds approximately 30.8% ... majority of Gamida Cell,s shareholders (including Elbit Medical), signed ...
(Date:8/18/2014)... , August 19, 2014 ... cell expansion technologies and therapeutic products, announced today that it ... Pharma AG  ( " Novartis " ... $35 million in Gamida Cell and in return will receive ... The option is exercisable for a limited period of time ...
(Date:8/18/2014)... YORK , Aug. 18, 2014 /PRNewswire/ ... research report is available in its catalogue: ... Biopharmaceutical Markets ... be categorized into three types: chromatography, membranes/filters ... products is increasing and fueling growth of ...
Breaking Medicine Technology:Elbit Imaging Announces Gamida Cell Signs Option and Investment Agreements with Major Pharmaceutical Company 2Elbit Imaging Announces Gamida Cell Signs Option and Investment Agreements with Major Pharmaceutical Company 3Gamida Cell Announces Investment and Option Agreement with Major Pharmaceutical Company 2Gamida Cell Announces Investment and Option Agreement with Major Pharmaceutical Company 3Gamida Cell Announces Investment and Option Agreement with Major Pharmaceutical Company 4Bioseparation Systems for Global Biopharmaceutical Markets 2Bioseparation Systems for Global Biopharmaceutical Markets 3Bioseparation Systems for Global Biopharmaceutical Markets 4Bioseparation Systems for Global Biopharmaceutical Markets 5Bioseparation Systems for Global Biopharmaceutical Markets 6Bioseparation Systems for Global Biopharmaceutical Markets 7Bioseparation Systems for Global Biopharmaceutical Markets 8Bioseparation Systems for Global Biopharmaceutical Markets 9Bioseparation Systems for Global Biopharmaceutical Markets 10Bioseparation Systems for Global Biopharmaceutical Markets 11Bioseparation Systems for Global Biopharmaceutical Markets 12
... Cempra Pharmaceuticals today announced results from its Phase ... tolerability of oral administration of our fourth generation ... with oral levofloxacin for the treatment of community-acquired ... CEM-101 demonstrated efficacy comparable to levofloxacin and a ...
... Sept. 15, 2011 Reportlinker.com announces that ... in its catalogue: Global ... http://www.reportlinker.com/p0240543/Global-Blood-Glucose-Test-Strips-Market-2010-2014.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic ... Test Strips market to grow at a ...
Cached Medicine Technology:Cempra Announces Comparable Efficacy of Oral Solithromycin (CEM-101) Compared with Levofloxacin in Phase II Clinical Trial in Patients with Community-Acquired Bacterial Pneumonia (CABP) 2Cempra Announces Comparable Efficacy of Oral Solithromycin (CEM-101) Compared with Levofloxacin in Phase II Clinical Trial in Patients with Community-Acquired Bacterial Pneumonia (CABP) 3Global Blood Glucose Test Strips Market 2010-2014 2
... EDTA K2 / gel tubes are ... for molecular diagnostics and for viral ... whole blood remain stable at room ... For optimal results, it is recommended ...
... offered as either EDTA K2 or ... calcium ions and therefore blocks the ... in an EDTA anticoagulated blood sample ... hours. EDTA tubes are for the ...
... is a ubiquitous enzyme that catalyzes ... is also the specific protein that ... immunofluorescence (EMA) tests (Bio-Rad catalog number ... serologic tests are highly sensitive and ...
... blood oximeters provide cardiologists with critical ... a patient's blood. The Oxicom series ... over a half-million saturation samples measured ... cost-effective oxygen saturation readings in less ...
Medicine Products: