Navigation Links
Novel cancer drug reduces neuroblastoma growth by 75 percent
Date:4/23/2009

SAN DIEGO - Researchers from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center have found a new drug that restricts the growth of neuroblastoma, a childhood brain cancer. The pre-clinical study was presented today in the plenary session at the 22nd annual meeting of the American Society of Pediatric Hematology/Oncology.

Alejandro Levy, M.D., fellow at the Children's Cancer Hospital at M. D. Anderson, presented research showing for the first time that the M. D. Anderson-developed drug, 3-BrOP, reduces tumor growth by more than 75 percent as a single agent. The study, conducted with human neuroblastoma cells transplanted into mice, showed how 3-BrOP, a glycolysis inhibitor, starved the cancer cells to death by shutting down their main energy source, glucose.

"We found that neuroblastoma cells, unlike healthy cells, are highly dependent on glycolysis for energy instead of more efficient means of energy production," said Levy. "Glycolysis is a process that breaks down sugar for energy, so by blocking that process with 3-BrOP, we are able to keep the tumors from producing energy, and this disrupts their ability to grow."

According to the American Cancer Society, approximately 650 children, mainly under the age of five, are diagnosed with neuroblastoma in the United States each year. Close to two-thirds of these children are diagnosed after the cancer has metastasized to other parts of the body. For these patients with high-risk neuroblastoma, long-term survival is less than 40 percent because the tumors are often resistant to traditional chemotherapy.

Pre-clinically, 3-BrOP has already been proven effective against other cancers including glioblastoma, colon cancer, lymphoma and acute leukemia. A Phase I clinical trial is planned to open this year for adult patients.

"As we explore alternative options to standard chemotherapy agents, we are finding drugs, like 3-BrOP, that have the pot
'/>"/>

Contact: Lindsay Anderson
lindsay.anderson@gabbe.com
212-220-4444
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Porter Novelli Begins Work With NHLBI on COPD Awareness Effort
2. Ethicon Endo-Surgery Novel Investigational Notes and SSL Devices Featured in 15 Presentations at Sages
3. Singapore First in Southeast Asia to Use Novel Treatment for Sports and Musculoskeletal Injuries
4. Mount Sinai researchers discover novel mechanisms that might causally link type-2 diabetes to Alzheimers disease
5. A Decision Beyond Life and Death: Novel Examines Effects of Controversial Procedure on Patients, Their Families and Doctors
6. Weight Watchers(R) Expands Licensed Food Categories with Launch of New Baked Goods, Frozen Novelty and Cheese Products to Encourage a More Sensible Lifestyle
7. Glissandra Skincare Inc. Launches Website Showcasing New and Novel Anti-Aging Skincare Products
8. AFRAID TO GO HOME, A Novel About Violence Against Women, Released By Tristan/Isolde Publishing
9. Endo Licenses Novel Pain Therapy from Grunenthal
10. Derma Sciences Gains FDA Clearance for Novel BIOGUARD(TM) Barrier Dressing with NIMBUS(R) Technology
11. Frost & Sullivan: Novel Diagnostics Methods Driving the European Cancer IVD Market Towards Early Detection and Prevention
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Physicians in China are most eagerly awaiting ... non-Hodgkin’s lymphoma (NHL), according to a new report from ... firm. MabThera is the only biologic available to treat ... of NHL. , According to Kantar Health’s report, “Biosimilars ... NHL in China has been growing and is expected ...
(Date:12/22/2014)... Only weeks following the announcement that ... to have a battery manufacturer create 29 well-paying jobs ... ) is launching in Henderson to deliver yet ... strong manufacturing sector is going to build a stronger ... “and TalkLocal works with small businesses that rely on ...
(Date:12/22/2014)... Pasadena, CA (PRWEB) December 22, 2014 ... is now offering consultations for sleep apnea. Drowsy drivers ... crashes than drivers who are well-rested, and some experts ... on the roads as intoxicated drivers. Unfortunately, millions of ... to the American Academy of Sleep Medicine, about 18 ...
(Date:12/22/2014)... Luxury Linen purveyor Peacock Alley once again joined ... logistics and support for one of Dallas’ largest holiday toy ... of giving back to the community in which it lives ... were Whataburger® and 99.5 The Wolf. , There is no ... to children who would otherwise not receive any is a ...
(Date:12/22/2014)... 21, 2014 A substantial percentage ... computed tomography (CT) to evaluate abnormal findings on ... cancer, according to a new study published online ... the findings show that radiologist recommendations for additional ... to patient care. , RAIs, which have grown ...
Breaking Medicine News(10 mins):Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 3Health News:TalkLocal Launches in Henderson Weeks Following New Megafactory, New Jobs Announcement 2Health News:Pasadena Dentist, Dr. Marine Martirosyan, Now Offers Consultations for Sleep Apnea 2Health News:Peacock Alley and Community Partners of Dallas Fulfill an Estimated 12,000 Holiday Wishes for Deserving Children 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 3
... , GAITHERSBURG, Md., Sept. 21 ... Services (HHS) has placed an order for an additional 29 million ... H1N1 influenza virus. This brings HHS orders to date to ... value of approximately $453 million. Previous HHS orders for approximately ...
... patients more likely to finish radiation course, study finds ... interrupted radiation treatment is a common problem among Medicare ... has found. , Researchers analyzed data from 5,086 Medicare ... and 2003 and found that nearly 40 percent of ...
... around the country, care is delayed, complicated and ... the same language. The situation is particularly dire ... York. Now, USC computer scientists, communication specialists ... robust and effective speech-to-speech (S2S) translation system for ...
... 2009 Results of a multicenter study in ... low rate of complications in diabetic patients, will be ... scientific symposium, sponsored by the Cardiovascular Research Foundation (CRF). ... on Clinical and Angiographic Outcomes in Diabetic Patients: Multicenter ...
... put your waistline at risk, according to a new study ... how other peoples, weight and food choices influence how much ... concern," write authors Brent McFerran, Darren W. Dahl (both University ... Morales (Arizona State University). "We decided to investigate how someone,s ...
... , NEW YORK, Sept. 21 PricewaterhouseCoopers, ... explore the business implications of one of the greatest domestic policy ... As the debate continues to rage in Washington, health industry ... upcoming PwC webcast series entitled 360 Degree Insight will ...
Cached Medicine News:Health News:MedImmune Receives U.S. Government Order for Additional 29 Million Doses of Nasal Spray Vaccine for 2009 H1N1 Influenza 2Health News:MedImmune Receives U.S. Government Order for Additional 29 Million Doses of Nasal Spray Vaccine for 2009 H1N1 Influenza 3Health News:Head, Neck Cancer Treatment Often Not Completed 2Health News:'The doctor can understand you now' 2Health News:'The doctor can understand you now' 3Health News:Researchers find drug-eluting stents safe, effective for PCI in diabetics 2Health News:Watching your weight? Beware of skinny friends with big appetites 2Health News:PricewaterhouseCoopers Announces Five-part Webcast Series on the Business Implications of Health Reform (Regardless of the Final Bill) 2Health News:PricewaterhouseCoopers Announces Five-part Webcast Series on the Business Implications of Health Reform (Regardless of the Final Bill) 3Health News:PricewaterhouseCoopers Announces Five-part Webcast Series on the Business Implications of Health Reform (Regardless of the Final Bill) 4
(Date:12/22/2014)... 2014 Apnea Sciences ( www.apneasciences.com ) announced ... Aliso Viejo , California.  Jimmy Fallon ... growth and worldwide expansion, a new facility with expanded ... anti snore cure have exceeded our expectations and thus ... now in 23 countries and will be increasing to ...
(Date:12/22/2014)... -- ConvaTec, a privately-held medical products and technologies company, today ... Executive Officer of the company, effective December 22, 2014. ... "The Board of Directors of ConvaTec thanks Mr. Berger ... three years," said Magnus Lundberg , the Chairman ... the company is well positioned for the future."  The ...
(Date:12/22/2014)... , Dec. 22, 2014  Mark Farrah Associates ... providing a summary of the 2015 marketplace exchange ... trends.  According to a recent ... and Evaluation, Department of Health and Human Services) ... in individual medical plans through the Marketplace as ...
Breaking Medicine Technology:ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2Insights into the Marketplace and Individual Market Growth 2
... Radiation Therapy Services Holdings, Inc. (the “Company”), a ... for the first quarter ended March 31, 2011. ... million, an increase of 16.4% compared to $134.5 million in ... revenue was principally due to revenue from the May 2010 ...
... EDGE, N.J., May 11, 2011 Nephros, Inc. (OTC ... company developing and marketing filtration products for therapeutic applications, ... May 10, 2011 the Company received approval from the ... regulatory agency, to market its Dual Stage Ultrafilters (DSU) ...
Cached Medicine Technology:Radiation Therapy Services Holdings, Inc. Reports First Quarter 2011 Financial Results 2Radiation Therapy Services Holdings, Inc. Reports First Quarter 2011 Financial Results 3Radiation Therapy Services Holdings, Inc. Reports First Quarter 2011 Financial Results 4Radiation Therapy Services Holdings, Inc. Reports First Quarter 2011 Financial Results 5Radiation Therapy Services Holdings, Inc. Reports First Quarter 2011 Financial Results 6Radiation Therapy Services Holdings, Inc. Reports First Quarter 2011 Financial Results 7Radiation Therapy Services Holdings, Inc. Reports First Quarter 2011 Financial Results 8Radiation Therapy Services Holdings, Inc. Reports First Quarter 2011 Financial Results 9Radiation Therapy Services Holdings, Inc. Reports First Quarter 2011 Financial Results 10Radiation Therapy Services Holdings, Inc. Reports First Quarter 2011 Financial Results 11Nephros Receives Approval to Market Dual Stage Ultrafilters in Canada 2Nephros Receives Approval to Market Dual Stage Ultrafilters in Canada 3Nephros Receives Approval to Market Dual Stage Ultrafilters in Canada 4
Cytomegalovirus IgM ELISA....
Small Incision Microforceps: Tano ILM Forceps...
Blunt tipped forceps with a thin tip angled at approximately 135 and hollowed out "notch" on the interior of the distal end. Tip is shaped like a pic when in the closed position. For membrane peeling...
Microforceps: Claes ILM Forceps...
Medicine Products: