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Novel bioreactor enhances interleukin-12 production in genetically-modified tobacco plants
Date:12/3/2008

ers said.

On the genetics side, the current study used a mouse gene as a model to test the idea and the process. Now, with positive results in hand, Cramer's team can begin to study a human interleukin-12 gene's ability to direct the production of the human protein in tobacco plants. "Making large complex pharmaceutical proteins in a way that is highly reproducible, scalable, and not cost prohibitive is quite challenging," Cramer says. "The mist reactor seems excellent for producing high-quality proteins for vaccine trials and therapeutic applications."

The mist reactor's capabilities are not restricted to tobacco roots. The system is being tested on several other plant cultures, including Artemisia annua, which naturally produces very small quantities of an effective antimalarial molecule known as artemisinin. "With our colleagues in Arkansas, we are making good progress on developing the technology and understanding the biology that will allow us to use plants to help create new pharmaceuticals and other chemical building blocks essential for a healthy society and environment," Professor Weathers said.


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Contact: Michael Cohen
mcohen@wpi.edu
508-868-4778
Worcester Polytechnic Institute
Source:Eurekalert

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