Navigation Links
Novel bioreactor enhances interleukin-12 production in genetically-modified tobacco plants
Date:12/3/2008

WORCESTER, Mass. Dec. 3, 2008 Interleukin-12 is a naturally occurring protein essential for the proper functioning of the human immune system. Having either too much or too little interleukin-12 may play a role in the development of many diseases, including some cancers and auto-immune disorders like Crohn's, psoriasis, and rheumatoid arthritis. In turn, modulating interleukin-12 levels could yield new therapies for those conditions.

In an effort to create a new and cost-effective method for producing interleukin-12 and make more of the scarce protein available for research and therapeutic development, a team of scientists at Worcester Polytechnic Institute's Life Sciences and Bioengineering Center (WPI) and the Arkansas Bioscience Institute at Arkansas State University (ABI) reports that hairy roots from genetically modified tobacco plants can be grown in a contained novel mist bioreactor system, yielding significant quantities of murine interleukin-12. A paper detailing the results of the study has been published early, online, by the journal Biotechnology and Bioengineering and will appear in the journal's printed edition early in 2009.

"We are very encouraged by the results of this study," says Pamela J. Weathers, PhD, professor of biology and biotechnology at WPI, co-author of the paper. "Interluekin-12 is a valuable protein and there just isn't enough available for biomedical research, let alone for therapeutic development. Our study shows that we can use plants to produce interleukin-12, and other therapeutic proteins, in a cost-effective controlled process."

The tobacco project is one of several emerging collaborative efforts between WPI and ABI. In the current study, tobacco plants were modified in the lab of Carole Cramer, PhD, ABI's executive director and co-author of the paper. Cramer's team successfully inserted into tobacco plants a mouse gene that directs the production of interleukin 12. Hairy root cultures fr
'/>"/>

Contact: Michael Cohen
mcohen@wpi.edu
508-868-4778
Worcester Polytechnic Institute
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Novel Techniques Offers New Freedom to Patients with Parkinson's Disease, Epilepsy, Dystonia, and Tremor
2. USC researchers identify novel approach for suppressing prostate cancer development
3. Studies show novel device may enhance chemotherapy treatment in brain tumors
4. Labopharm to host webcast presentation on novel trazodone formulation for treatment of major depressive disorder
5. Labopharms NDA for Novel Trazodone Formulation accepted for review by FDA
6. E6 Ventures Invests in Novel Coatings Developer, Diamond Hard Surfaces Ltd
7. Novel imaging technique reveals brain abnormalities that may play key role in ADHD
8. Future Looks Bright For Non-Invasive Diagnosis Of Skin Cancer; Study Shows Novel Light Device Detects Cancerous Lesions From Normal Tissue
9. Novel IBS treatment developed at UB garners $8.5 million for seven-year clinical trial
10. Novel 4-drug combination proves safe for lung cancer treatment
11. Porter Novelli Named Agency of Record for Pharmavite(R) LLC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2010)... , Feb. 9 The following ... Blackwell : ,, "Reversing the childhood obesity epidemic will ... Michelle Obama demonstrated today. ,, "As the ... schools loaded with chips and soda -- and few ... however, that bleak food landscape extends far beyond the ...
(Date:2/9/2010)... LearnSomething Inc., a leader in eLearning ... retailers, today announced that Phil Keough , ... consulting company, has joined LearnSomething,s senior management as ... select team with the mission to continue developing ... products and services for retailers, including vehicles for ...
(Date:2/9/2010)... Fla. , Feb. 9 The Quantum ... to the School District of Palm Beach County ... get fit. The Robert Wood Johnson Foundation (RWJF) recently announced ... activity and access to affordable healthy foods for children and ... Springs communities. Based on a rigorous selection process that ...
(Date:2/9/2010)... diagnosis among black women remained 30 percent to 90 ... 2004, according to new findings by researchers at Fred ... the incidence of advance colorectal cancer actually widened over ... increased slightly among blacks. , The findings are published ... Hormones and Cancer , a publication of the Endocrine ...
(Date:2/9/2010)... An iPhone application created by UH researchers ... around the world. Those annual rankings of America,s ... and a host of indirect indicators may soon ... collected at the University of Houston provides objective ... available free from Apple,s "App Store," allows users ...
Breaking Medicine News(10 mins):Health News:LearnSomething Brings Phil Keough On Board to Spearhead Retail Products and Services 2Health News:LearnSomething Brings Phil Keough On Board to Spearhead Retail Products and Services 3Health News:Planting Seeds to Fight Childhood Obesity 2Health News:Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S. 2Health News:Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S. 3Health News:Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S. 4Health News:Phone app providing real-time statistics on physical activity around the world 2Health News:Phone app providing real-time statistics on physical activity around the world 3
... /PRNewswire/ - IntelliPharmaCeutics is pleased to,provide an update ... to,the Company, include IntelliPharmaCeutics Ltd. and our operating ... active with drug development work at our,25,000 square ... We,presently have 34 staff employed full-time including 21 ...
... Md., Aug. 8 The Health Resources,and Services ... new,health center grants to help people in need ... to the comprehensive primary and preventive,health care services ... health care," said HRSA Administrator,Elizabeth Duke. "These awards ...
... marker for those most likely to die suddenly, study says ... turbulence (HRT) appears to indicate a significant risk for sudden ... , The study, published in the August HeartRhythm Journal ... all-cause mortality and heart failure progression, as well as sudden ...
... as President and Chief Executive Officer; Evelyn ... Chief Executive Officer -, LA JOLLA, Calif., Aug. 8 ... Neil Kurtz, M.D., is,resigning as President, Chief Executive Officer and ... Dr. Kurtz is leaving TorreyPines,to assume the role of President ...
... Higher adiponectin levels may indicate underlying disease, study finds , , ... fat cells may play a pivotal role in increasing an ... are losing weight, a new report says. , Levels of ... appear to endanger the cardiovascular health of older people, according ...
... and Intrinsic LifeSciences, a San Diego biotech company, developed the ... absorption of dietary iron and its distribution in the body. ... chronic conditions affecting millions of people worldwide such as anemias ... test will measure the amount of hepcidin in the blood. ...
Other Medicine News:Health News:IntelliPharmaCeutics Provides Update on Activities 2Health News:IntelliPharmaCeutics Provides Update on Activities 3Health News:IntelliPharmaCeutics Provides Update on Activities 4Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 2Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 3Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 4Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 5Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 6Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 7Health News:Fat Cell Protein Boosts Heart Attack Risk in Elderly 2
(Date:2/9/2010)... YORK , Feb. 9 ... print and print-on-demand publication from LIVE STRONG .  The ... fight against cancer; resources and information about cancer prevention ... wellness. ,, "As a three-time cancer survivor, I ... a personal level," said LIVE STRONG President and ...
(Date:2/9/2010)... YORK , Feb. 9 /PRNewswire/ ... research report is available in its catalogue: ... Analysis and Market Forecasts to 2016 ... - Drug Pipeline Analysis and Market Forecasts ... GlobalData, the industry analysis specialist,s new report, ...
(Date:2/9/2010)... Ligon Discovery announced today that ... Lycera Corporation to apply its Small Molecule Microarray ... for immune disorders. Ligon will apply its SMM ... as critical to the development of certain immune ... "By partnering with Lycera, a leader in the ...
Breaking Medicine Technology:SPOT ON media and LIVESTRONG(R) Launch LIVESTRONG Quarterly 2SPOT ON media and LIVESTRONG(R) Launch LIVESTRONG Quarterly 3SPOT ON media and LIVESTRONG(R) Launch LIVESTRONG Quarterly 4Reportlinker Adds Atrial Fibrillation - Drug Pipeline Analysis and Market Forecasts to 2016 2Reportlinker Adds Atrial Fibrillation - Drug Pipeline Analysis and Market Forecasts to 2016 3Reportlinker Adds Atrial Fibrillation - Drug Pipeline Analysis and Market Forecasts to 2016 4Reportlinker Adds Atrial Fibrillation - Drug Pipeline Analysis and Market Forecasts to 2016 5Reportlinker Adds Atrial Fibrillation - Drug Pipeline Analysis and Market Forecasts to 2016 6Reportlinker Adds Atrial Fibrillation - Drug Pipeline Analysis and Market Forecasts to 2016 7Reportlinker Adds Atrial Fibrillation - Drug Pipeline Analysis and Market Forecasts to 2016 8Ligon Discovery and Lycera Collaborate to Develop First-in-Class Drugs for Immune Disorders 2Ligon Discovery and Lycera Collaborate to Develop First-in-Class Drugs for Immune Disorders 3The future of electricity may be found in environmentally friendly thermoelectric cells 14499 1ResMed Announces Conference Call and Webcast to Discuss First Quarter 2010 Results 59606 1ResMed Announces Conference Call and Webcast to Discuss First Quarter 2010 Results 59606 2deverus 28TM 29 Expands Operations Overseas 59602 1deverus 28TM 29 Expands Operations Overseas 59602 2
... are six months old in a home-based program that ... hearing are not only able to achieve appropriate language ... to a new study.The study underscores the importance of ... a more detailed evaluation of a baby,s hearing by ...
... Transcept Pharmaceuticals, Inc. (Nasdaq: TSPT ), ... commercialization of proprietary products that address important therapeutic needs ... report results for its first quarter 2009 on Wednesday, ... review the results will begin at 5:00 p.m. ET ...
Other Medicine Technology:Program Improves Language Skills in Deaf, Hard of Hearing 2Program Improves Language Skills in Deaf, Hard of Hearing 3Transcept Pharmaceuticals to Report First Quarter 2009 Results 2Transcept Pharmaceuticals to Report First Quarter 2009 Results 3
Measure SpO2 and tcpCO2 with a single sensor....
... analyzer data via the Internet and ... peer group. , ,Worldwide DATACHECK's ... perform statistical analysis of your QC ... you like. Peer-group data are continuously ...
... Radiometer University is the only online ... for respiratory therapists, critical care nurses and ... available online 24/7, so you can take ... available, and a certificate is issued upon ...
... three software components that comprise the ... software components comprise the SmartPill GI ... SmartPill Data Receiver software and SmartPill ... integrated and indispensable parts of the ...
Medicine Products: