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Novel biomarker may predict response to new VEGF receptor inhibitor
Date:9/28/2010

DENVER Researchers believe there may be a way to predict, based on individual tumors, those patients that are more likely to respond to the investigational new drug tivozanib.

This is possible, the researchers from AVEO Pharmaceuticals, Inc. said, because they have used a new way of creating animal tumor models that mimic tumor variation seen in human. Based on the results of these studies, they have found a single biomarker that may predict resistance to tivozanib, an oral, triple VEGF (vascular endothelial growth factor) receptor inhibitor.

Tivozanib is in an ongoing Phase III registration trial in kidney cancer, which recently completed enrollment of 500 patients ahead of schedule, and is in multiple early trials in patients with breast, colon and lung cancer.

In a study being presented at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development, the researchers said that the biomarker reflects the presence of certain white blood cells inside a tumor.

"Predictive biomarkers that can be used to assess activity of treatments are what we are all striving for in cancer therapy today," said Murray Robinson, Ph.D., senior vice president, translational medicine, at AVEO Pharmaceuticals, Inc., in Cambridge, Mass. "We want to know in advance which patients are most likely to respond to an anticancer therapy, and in this way, spare patients who cannot respond from ineffective therapy."

In its ongoing trials, the company is collecting biomarker data in order to correlate the presence of the biomarker with clinical activity. "This is a necessary step that we must do to validate the predictive value of the biomarker," Robinson said.

To date, the researchers have evaluated 600 human tumor samples across eight different tumor types.

"We saw the biomarker in subsets of all the human tumor types we looked at. Based on these findings, we believe that the biomarker di
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Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

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