Navigation Links
Novel biomarker approach suggests new avenues to improve schizophrenia disease management
Date:1/9/2014

Environmental effects of events such as oxygen deprivation and infections may be preserved as markers in blood that are associated to schizophrenia, according to an international study led by the Virginia Commonwealth University School of Pharmacy's Center for Biomarker Research and Personalized Medicine.

"These markers, possibly from as early as embryonic development or birth, could be of considerable clinical importance as they could allow for identification of distinct schizophrenia subtypes or help predict treatment responses," said Karolina Aberg, Ph.D., associate director of the Center for Biomarker Research and Personalized Medicine and first author of the study.

Schizophrenia is a devastating psychiatric disorder. Although there is strong support for the involvement of DNA sequence variation in the development of the disorder, other factors such as environmental influences are also likely to play a major role.

The research team performed one of the first large-scale, methylome-wide association studies (MWAS) of schizophrenia, as detailed online in the January issue of JAMA Psychiatry, the JAMA Network journal.

"Methylation is a specific modification to the DNA molecule that could potentially reflect environmental events," said Edwin van den Oord, Ph.D., director of the Center for Biomarker Research and Personalized Medicine and senior author of the study. "Therefore, DNA methylation studies are very promising complements to traditional genetic studies that potentially can give us a deeper understanding of the schizophrenia disease etiology."

In this study, researchers investigated approximately 27 million DNA methylation markings in blood samples from 1,497 schizophrenia cases and controls.

This methylome-wide screening was performed by extracting the methylated portion of the genome and then investigating this portion with massively parallel next-generation sequencing. To ensure that the findings from this screening were not false findings caused, for example, by method-specific artifacts or statistical errors, researchers used a different technology to follow up the critical top findings in independent subjects who were not part of the initial screening step.

The study identified 139 highly significant methylation sites. Many of the replicating markings could be linked to hypoxia, immune response and neuronal differentiation, which are risk factors previously associated with schizophrenia development.


'/>"/>

Contact: Eric Peters
petersem@vcu.edu
804-828-0563
Virginia Commonwealth University
Source:Eurekalert  

Related medicine news :

1. Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment
2. Rutgers team discovers novel approach to stimulate immune cells
3. Novel drug candidates offer new route to controlling inflammation
4. Researchers present new findings for novel pancreatic cancer vaccine
5. Novel biomarkers reveal evidence of radiation exposure
6. VCU Massey Cancer Center sees potential in novel leukemia treatment
7. Study supports urate protection against Parkinsons disease, hints at novel mechanism
8. Novel Natural Sciences Repository Opens Web Portal
9. Novel Anti-Inflammatories May Offer a New Approach for the Treatment of Stroke
10. LA BioMed investigators, Drs. Kevin Bruhn and Noah Craft, develop novel treatment for melanoma
11. Novel radiation therapy safely treats prostate cancer and lowers the risk of recurrence
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel biomarker approach suggests new avenues to improve schizophrenia disease management
(Date:6/27/2016)... California (PRWEB) , ... June ... ... pioneer in the patient payment industry today announced its strategic partnership with ... health system workflows. , The two companies’ proven, proprietary technology combine to ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can now ... and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings ... The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Dehaier Medical Systems Ltd. (NASDAQ: DHRM ... sells medical devices and wearable sleep respiratory products in ... agreement with Hongyuan Supply Chain Management Co., Ltd. (hereinafter ... 2016, to develop Dehaier,s new Internet medical technology business. ... leverage Hongyuan Supply Chain,s sales platform to reach Dehaier,s ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
(Date:6/23/2016)... 2016 Research and Markets has ... by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), ... Parenteral) - Global Forecast to 2021" report to ... The global pharmaceutical excipients market is projected to reach ... 6.1% in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: