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Novel autoantibodies identified in patients with necrotizing myopathy
Date:8/19/2010

ntibodies, revealing unique autoantibody specificity against 200-kd and 100-kd proteins (anti-200/100 autoantibodies) in 16 patients. Further analysis of the clinical characteristics and muscle biopsy features of these 16 patients suggests they belong to the family of autoimmune myopathies responsive to immunosuppressive therapy.

Researchers found sera from patients with anti-200/100 autoantibodies did not recognize any of the SRP subunits, and sera from patients with anti-SRP autoantibodies did not recognize proteins with molecular weights of 200-kd or 100-kd, demonstrating that patients with the anti-200/100 autoantibody specificity are immunologically distinct from patients with anti-SRP antibodies. Furthermore, researchers noted that several anti-200/100 autoantibodypositive patients had extremely high CK levels with minimal weakness, while patients with anti-SRP antibodies and similarly high CK levels are typically very weak, suggesting the sub-group represents a unique autoimmune-based disease.

Another unique feature of the anti-200/100 autoantibodypositive group is that 63% of them underwent statin therapy prior to the development of muscle symptoms. This association was strongest in older patients; almost 90% of anti-200/100 autoantibodypositive patients ages 50 years or older had been exposed to statins. This rate was significantly higher than the rates of statin treatment in age-matched groups of patients with PM, DM, or IBM.

"We have identified a group of patients with a necrotizing myopathy and a novel anti-200/100 autoantibody specificity," said Dr. Andrew Mammen, M.D., Ph.D., and lead author of the study. "All of the patients responded to immunosuppression, and many experienced a flare of weakness when this treatment was tapered, which supports our hypothesis that this is an immune-mediated myopathy." Researchers concluded that patients with necrotizing myopathies and anti-200/100 autoantibodies most likely have an autoimm
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Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

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