Navigation Links
Novel approach to treating breast cancer shows great promise
Date:12/7/2011

MAYWOOD, Il. -- In a novel therapeutic approach to treating breast cancer, Loyola University Medical Center researchers are reporting positive results from a clinical trial of a drug that targets tumor stem cells.

Existing cancer drugs are effective in killing mature cancer cells. But a handful of cancer stem cells are resistant to such drugs. They survive and go on to develop into new tumor cells.

A pilot study at Loyola found that an experimental drug known as a "notch inhibitor" appears to block this process by turning off key genes. Kathy Albain, MD, who led the study, presented findings Dec. 7 during the 2011 CTRC-AACR San Antonio Breast Cancer Symposium.

Albain collaborated with scientists from Loyola, University of Mississippi Cancer Center, Baylor Breast Center and Merck Oncology.

"Our results suggest a potential role that notch inhibitors could play in optimizing existing therapies and in overcoming resistance to cancer drugs," Albain said.

The so-called notch protein promotes tumor growth and survival. The protein is present on the surface of cancer stem cells. The protein latches on to other cells, and the resulting "molecular handshake" activates various genes in the stem cells. Activating these genes, in effect, makes the stem cells resistant to common cancer drugs.

The study included 20 patients who finished all therapy. The women all had early-stage, estrogen-receptor-positive breast cancer.

Prior to surgery, the patients received one of two commonly used drugs, tamoxifen or letrozole. These drugs work by blocking estrogen stimulation of breast cancer cells. In addition to tamoxifen or letrozole, patients also received the experimental notch-inhibitor drug, MK-0752.

Following treatment with the notch inhibitor, patients underwent biopsies to provide tumor specimens. Researchers found that the drug turned off the key genes that in effect would have kept the tumor stem cells resistant to conventional drugs.

"The
'/>"/>

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH grants to Childrens Hospital will advance novel stem cell treatments for blood disorders
2. A novel in vitro model for light-induced wound healing
3. Novel program translates behavioral and social science research into treatments to reduce obesity
4. Reovirus may be a novel approach to prostate cancer treatment
5. Novel stroke treatment passes safety stage of UCI-led clinical trial
6. Novel medical home program for pediatric patients, families cuts ER visits in half
7. MessageSolution First in the Market to Offer All-in-One, Integrated Cloud-Based Archiving for Email, File Systems and SharePoint at Novell BrainShare 2010
8. Novel Parkinson's Treatment Strategy Involves Cell Transplantation
9. Novel Method Eyed for Normalizing Blood Sugar
10. Novel soy germ-based dietary supplement, SE5-OH containing natural S-Equol, examined for safety and influence on hormones in pre- and post-menopausal women
11. Novel nanoparticles prevent radiation damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... ... September 01, 2015 , ... ... has announced that Edge Information Management has been granted continued accreditation ... Credentialing Council (BSCC). , “Achieving and maintaining this accreditation takes the ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... and analysis of pet vital signs and activity, today announced its integration with ... the most popular and widely-adopted veterinary hospital Practice Management Software packages in the ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... and government entities, announced today that it has hired Scott Sanderson, an experienced ... In this capacity, Sanderson will be responsible for establishing and managing new client ...
(Date:9/1/2015)... ... 2015 , ... Royal River Natural Foods, a locally-owned independent natural health store ... 19 years and found that, among those who had a stroke, people who used ... part of the September 2015 issue of “Natural Insights for Well Being,” which Royal ...
(Date:9/1/2015)... ... September 01, 2015 , ... WorkCare, ... has joined its medical management team as an Associate Medical Director. , ... and types in the U.S. and abroad. , Dr. Nelson has a ...
Breaking Medicine News(10 mins):Health News:Edge Information Management Granted Continued NAPBS Accreditation 2Health News:Edge Information Management Granted Continued NAPBS Accreditation 3Health News:Petpace-Cornerstone Integration Lowers Overhead, Raises Data Visibility for Veterinary Practices 2Health News:Former NFL Standout Scott Sanderson Joins eDiscovery Leader Discovia 2Health News:New Study Finds Multivitamins Extend Life After Stroke, Retailer Reports 2Health News:Dr. Brent Nelson Joins WorkCare, Inc., as Associate Medical Director 2Health News:Dr. Brent Nelson Joins WorkCare, Inc., as Associate Medical Director 3
... , , , ... Los Angeles today announced that Caroline W. Nahas, managing director of ... the new volunteer chair of the organization,s corporate board of directors. ... served in this important role. Nahas will replace outgoing board chair, ...
... four sites across the country to participate in a new ... the effectiveness of a chemotherapeutic agent, ThermoDox, used in conjunction ... recurrent chest wall breast cancer. Recurrent chest wall ... the chest wall, most commonly presenting in the skin overlying ...
... ... tips on keeping kids healthy and active this summer , ... Minneapolis, MN (PRWEB) July 20, 2009 -- On soccer fields ... enjoy the summer sun. While the occasional bump or bruise is expected and normal, some ...
... , NAPERVILLE, Ill., July 20 The ... that Maryjane A. Wurth, 53, Chief Operating Officer, Healthcare Association of ... of IHA. Wurth succeeds Ken Robbins, who has served as IHA ... assume her duties as IHA,s president in October. , ...
... to view smoking-related content, study shows, , MONDAY, July 20 ... isn,t watching TV shows or movies that glamorize smoking, he ... the Internet, particularly from popular social networking sites such as ... 20 in Pediatrics , found that the Internet is ...
... , CAMP HILL, Pa., July 20 Highmark Blue Shield ... Health Conference, set for Saturday, Aug. 29 from 6:30 a.m. until 3 ... and University Drive in Hershey, Pa. , , ... a greater hand in their health by attending Fun, Fit & Fabulous! ...
Cached Medicine News:Health News:Caroline W. Nahas Named New Corporate Board Chair for United Way of Greater Los Angeles 2Health News:Caroline W. Nahas Named New Corporate Board Chair for United Way of Greater Los Angeles 3Health News:RI Hospital first in country to enroll patient in new study for recurrent chest wall breast cancer 2Health News:Treating Kids' Summertime Bumps, Bruises and Injuries with The Healthcare Scoop 2Health News:Treating Kids' Summertime Bumps, Bruises and Injuries with The Healthcare Scoop 3Health News:Maryjane A. Wurth Named New President of Illinois Hospital Association 2Health News:Internet May Be Newest Venue for Teen Tobacco Exposure 2Health News:Internet May Be Newest Venue for Teen Tobacco Exposure 3Health News:Feel Fun, Fit & Fabulous! At the 2009 Women's Health Conference 2Health News:Feel Fun, Fit & Fabulous! At the 2009 Women's Health Conference 3
(Date:9/1/2015)... UT Southwestern Medical Center President Dr. Daniel K. ... Michael C. Burgess , M.D., and Joe ... st Century Cures Act, bipartisan legislation in support ... the United States Senate. UT ... department chairs, center directors, and leading researchers – joined ...
(Date:9/1/2015)... , Sept. 1, 2015   Alpha Imaging LLC , a ... Cleveland announced today that they have been awarded exclusive ... imaging systems in Michigan.   The new territory supplements Alpha Imaging,s existing ... including Ohio , Indiana , ... Maryland , West Virginia , ...
(Date:9/1/2015)... Taiwan,s GNT Biotech & Medicals ... Taipei on  August 25 th  to ... drug delivery technology that uses nano-scale gold as the ... a joint press conference held by its parent company ... latest edible gold-based food and beverage partners, together with ...
Breaking Medicine Technology:U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 2U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 3U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 4U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 5Alpha Imaging Expands Shimadzu Territory 2GNTbm Updates Developments in the Vaucarrin(TM) annogold Drug Delivery Platform 2GNTbm Updates Developments in the Vaucarrin(TM) annogold Drug Delivery Platform 3GNTbm Updates Developments in the Vaucarrin(TM) annogold Drug Delivery Platform 4GNTbm Updates Developments in the Vaucarrin(TM) annogold Drug Delivery Platform 5
... NEW DELHI, October 7 DBMS Consulting announced that ... Suite and Oracle E-Business Suite (EBS) for SIRO Clinpharm, ... OHSA offers fully,automated capabilities in management of clinical trial ... After this implementation, SIRO gains ...
... SAN DIEGO and BASKING RIDGE, N.J., Oct. 7 With ... said today from CTIA WIRELESS I.T. & Entertainment 2009® that ... for its Field Force Manager application that helps address the ... become more productive and efficient. , Designed specifically ...
Cached Medicine Technology:DBMS Consulting Successfully Completes Roll out of Oracle Health Sciences Applications (OHSA) Suite for SIRO Clinpharm 2DBMS Consulting Successfully Completes Roll out of Oracle Health Sciences Applications (OHSA) Suite for SIRO Clinpharm 3Verizon Wireless Offers Home Health Care Industry Custom Mobile Application To Be More Productive 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: