Navigation Links
Novel approach to treating breast cancer shows great promise
Date:12/7/2011

MAYWOOD, Il. -- In a novel therapeutic approach to treating breast cancer, Loyola University Medical Center researchers are reporting positive results from a clinical trial of a drug that targets tumor stem cells.

Existing cancer drugs are effective in killing mature cancer cells. But a handful of cancer stem cells are resistant to such drugs. They survive and go on to develop into new tumor cells.

A pilot study at Loyola found that an experimental drug known as a "notch inhibitor" appears to block this process by turning off key genes. Kathy Albain, MD, who led the study, presented findings Dec. 7 during the 2011 CTRC-AACR San Antonio Breast Cancer Symposium.

Albain collaborated with scientists from Loyola, University of Mississippi Cancer Center, Baylor Breast Center and Merck Oncology.

"Our results suggest a potential role that notch inhibitors could play in optimizing existing therapies and in overcoming resistance to cancer drugs," Albain said.

The so-called notch protein promotes tumor growth and survival. The protein is present on the surface of cancer stem cells. The protein latches on to other cells, and the resulting "molecular handshake" activates various genes in the stem cells. Activating these genes, in effect, makes the stem cells resistant to common cancer drugs.

The study included 20 patients who finished all therapy. The women all had early-stage, estrogen-receptor-positive breast cancer.

Prior to surgery, the patients received one of two commonly used drugs, tamoxifen or letrozole. These drugs work by blocking estrogen stimulation of breast cancer cells. In addition to tamoxifen or letrozole, patients also received the experimental notch-inhibitor drug, MK-0752.

Following treatment with the notch inhibitor, patients underwent biopsies to provide tumor specimens. Researchers found that the drug turned off the key genes that in effect would have kept the tumor stem cells resistant to conventional drugs.

"The
'/>"/>

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH grants to Childrens Hospital will advance novel stem cell treatments for blood disorders
2. A novel in vitro model for light-induced wound healing
3. Novel program translates behavioral and social science research into treatments to reduce obesity
4. Reovirus may be a novel approach to prostate cancer treatment
5. Novel stroke treatment passes safety stage of UCI-led clinical trial
6. Novel medical home program for pediatric patients, families cuts ER visits in half
7. MessageSolution First in the Market to Offer All-in-One, Integrated Cloud-Based Archiving for Email, File Systems and SharePoint at Novell BrainShare 2010
8. Novel Parkinson's Treatment Strategy Involves Cell Transplantation
9. Novel Method Eyed for Normalizing Blood Sugar
10. Novel soy germ-based dietary supplement, SE5-OH containing natural S-Equol, examined for safety and influence on hormones in pre- and post-menopausal women
11. Novel nanoparticles prevent radiation damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... 2014 As part of its ... LLP has been closely monitoring the ongoing meeting ... Obstetrics and Gynecology Devices Panel, which has ... cancer risks associated with the use of power ... a report published by Dow Jones Business News, ...
(Date:7/11/2014)... 2014 Utilizing the Keller Funnel, ... Koenig, has topped a record number of complication-free breast ... over 400 successful procedures without the occurrence of a ... known across the country for his expertise with the ... long been the foundation for numerous studies and research. ...
(Date:7/11/2014)... 2014 (HealthDay News) -- U.S. health officials have concluded ... to live anthrax during a safety mishap last month. ... Prevention officials have announced a moratorium on the transfer ... labs. In a report issued Friday, the CDC ... sure a similar incident doesn,t occur again. Last month, ...
(Date:7/11/2014)... According to a new market research report ... Technology (ZigBee, Z-Wave, Bluetooth, Wi-Fi, NFC, RFID), Application Vertical ... Agriculture) & Geography - Global Trends & Forecasts to ... market was worth $1029.5 Billion in 2013, and is ... estimated CAGR of 4.08% from 2014 to 2020. ...
(Date:7/11/2014)... As reported by the New ... a significant number of severe adverse events such as ... even death from the highly-promoted and costly immune-system drug, ... report , a regulatory filing revealed that the ... was almost 14% of prescriptions, up from 9.1% in ...
Breaking Medicine News(10 mins):Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Financial Ties Between FDA Advisory Panel Members and Manufacturers of Power Morcellators 2Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Financial Ties Between FDA Advisory Panel Members and Manufacturers of Power Morcellators 3Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Financial Ties Between FDA Advisory Panel Members and Manufacturers of Power Morcellators 4Health News:Rochester Surgeon Hits Milestone with Keller Funnel 2Health News:CDC Issues Tough Report on Anthrax Scare 2Health News:Internet of Things Technology & Application Market Worth $1423.09 Billion by 2020 – New Report by MarketsandMarkets 2Health News:Internet of Things Technology & Application Market Worth $1423.09 Billion by 2020 – New Report by MarketsandMarkets 3Health News:Internet of Things Technology & Application Market Worth $1423.09 Billion by 2020 – New Report by MarketsandMarkets 4Health News:Acthar’s Deadly Adverse Events Revealed 2Health News:Acthar’s Deadly Adverse Events Revealed 3
... of your father when you are born may affect ... increased risk of schizophrenia associated with advanced paternal age, ... that distorts the way a person thinks, acts, expresses ... a life-long disease that cannot be cured, but usually ...
... a disorder affecting more than 2 million people worldwide and ... the brain that result in seizures. More than half of ... now a new study is under way to determine just ... those with temporal lobe epilepsy, //the most common form of ...
... Having a short version of a certain gene may make ... losing a job or a loved one. People only have ... to become more vulnerable to depression, the researchers in Britain, ... as divorce or illness, are well-known triggers for depression--one of ...
... the long-term consequences of too much sun exposure can be ... anyone who's spent a day basking on the beach. ,Characterized ... to the touch, sunburn is a sure, almost immediate sign ... been damaged by the sun's ultraviolet rays. And the consequences ...
... a woman’s bones and a new study reveals a good ... bone loss occurs after menopause, increasing chances of a fracture. ... ,The Swedish study involved 146 women who were followed through ... determine bone size and density. //All fractures related to a ...
... fish at least once a week may cut their risk ... study adds to the evidence that diet may affect a ... million Americans. ,Researchers found that people 65 and older ... lower risk of Alzheimer's than those who never or rarely ...
Cached Medicine News:
(Date:7/10/2014)... 11, 2014  Major advances in radiation therapy ... being highlighted in a three-day Oncology Summit taking ... July, 2014.  Renowned national and international cancer experts from ... and exchange knowledge on modern technologies making treatment ... The Summit will address a ...
(Date:7/10/2014)... , July 10, 2014  Breg, Inc., a ... has launched the FreeRunner™ knee brace with new ... from patella mal-tracking return to active lifestyles.  FreeRunner,s ... other braces, providing support when patients need it ... they don,t. Patellofemoral issues are the ...
(Date:7/10/2014)... , July 10, 2014 Yesterday, former ... (Moberg) medical device manufacturing facility. Rep. Kennedy and ... neurological monitors facilitate cutting-edge research in neurological disease ... and mental health advocate, Garen Staglin , ... to fostering fundamental changes that will radically accelerate ...
Breaking Medicine Technology:Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2
... WAUKESHA, Wis., Sept. 29 MedPro Imaging, a premier ... of its Ultrasound Transducer Repair Division.  Based on proprietary ... MedPro Imaging will offer high quality computer-based transducer repair ... industry on probe exchange programs. "The industry ...
... 29 Crosstex International, a subsidiary of ... today the publication of sponsored research that suggests a ... commonly referred to as surgical masks, than previously understood. ... mask or respirator is most effective when worn by ...
Cached Medicine Technology:MedPro Imaging Launches Ultrasound Transducer Repair Division 2New Mask Study Supports CDC's Updated Guidance for Seasonal Flu Prevention Strategies 2New Mask Study Supports CDC's Updated Guidance for Seasonal Flu Prevention Strategies 3
... a licensed 96 well PCR machine, developed to ... thermal cycling. It is built on the ... and retains a high level of accuracy and ... the range. The combination of robustness, affordability ...
... Family offers fast temperature control, exact block ... Personal cards enable safe program storage as ... individual protocols between different Mastercyclers. All models ... come with a two-year warranty. The ...
... 96 Thermal Cyclers provide comprehensive state-of-the-art PCR ... ideal instruments for the optimization of sensitive ... low to medium throughput PCR and sequencing ... well block allows a choice of consumables: ...
... graphical touch screen display which enables you ... of a screen." Features & Benefits ... Graphical Display, Memory Cards, Gradient Calculator, Fold ... Programmin, Free Instrument Software Upgrade. Includes ...
Medicine Products: