Navigation Links
Novel approach to treat proliferative vitreoretinopathy shows promise
Date:10/30/2011

Philadelphia, PA -- Proliferative vitreoretinopathy (PVR), or the formation of scar tissue within the eye, is a serious, sight-threatening complication in patients recovering surgical repair of retinal detachment. A new study conducted by investigators at the Schepens Eye Research Institute, the Department of Ophthalmology at Harvard Medical School, and the Massachusetts Eye and Ear Infirmary in Boston, published in the December issue of the American Journal of Pathology, suggests that a cocktail containing reagents to neutralize a relatively small subset of vitreal growth factors and cytokines may be an effective treatment.

"We found that a combination of 7 classes of growth factors and cytokines was essential for PVR to develop in an animal model of the disease," explains lead investigator Andrius Kazlauskas, PhD, of The Schepens Eye Research Institute and the Department of Ophthalmology, Harvard Medical School. "By neutralizing them, we prevented PVR-relevant signaling, and inhibited contraction of collagen gels containing primary retinal pigment epithelial cells derived from a human PVR membrane (RPEMs). These findings suggest a potential therapeutic approach to reduce the incidence of PVR in patients undergoing surgery to repair a detached retina."

In animal models, platelet-derived growth factor receptor α (PDGFRα) is associated with PVR and strongly promotes experimental PVR. Vitreal growth factors outside of the PDGF family promote an indirect route to activate PDGFRα. Importantly, indirectly activated PDGFRα engages a characteristic set of signaling events and cellular responses that are tightly associated with PVR. This study sought to identify the factors that would induce those events, and develop therapeutic approaches to prevent patients from developing PVR.

Vitreous was obtained from normal rabbits or those in which PVR was either developing or stabilized. Normal vitreous was found to
'/>"/>

Contact: David Sampson
ajpmedia@elsevier.com
215-239-3171
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Novel strategy stymies SARS et al.
2. Novel therapeutic target identified to decrease triglycerides and increase good cholesterol
3. Innovation at Regenstrief: Leveraging novel ideas to improve health care
4. Novel technique reveals both gene number and protein expression simultaneously
5. Novel research set to pinpoint risk of heart attacks and strokes
6. Novel cytokine protects mice from colitis
7. FDA Approves Novel Melanoma Drug
8. St. Michaels North America first to use novel blood-cleaning procedure for kidney transplant
9. Novel DNA sequencer for MDCs systems biology
10. Novel Virus Jumped From Monkeys to Humans, Researchers Find
11. Novel combined therapy extends life, diminishes pain in brain cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... 28, 2015 , ... SharkNinja, an innovative leader in the ... actress, Sofia Vergara, and unveil the Ninja® brand’s new coffee machine, the ... a variety of sizes and styles while achieving the perfect brew richness level ...
(Date:8/28/2015)... ... 28, 2015 , ... United Benefit Advisors (UBA), the nation’s ... as its newest Partner Firm. Founded in 1924 and headquartered in Pittsburgh, Pennsylvania, ... their goals. Within the past 10 years, TJS Insurance Group has emerged as ...
(Date:8/28/2015)... Knoxville, TN (PRWEB) , ... August 28, 2015 , ... ... surrounding the Centers for Medicare & Medicaid Services’ (CMS) proposal to mandate bundled ... 45-minute webinar , “Get Ready for Game Day: Comprehensive Care for Joint Replacement,” ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... Santa Rosa ... to Work in Healthcare by Modern Healthcare. In the KLAS “2015 Midterm Performance Review: ... , “We believe the recognitions from Modern Healthcare and KLAS are directly related ...
(Date:8/27/2015)... Caicos Islands, BWI (PRWEB) , ... August 28, 2015 , ... ... for weddings. This award is added to an already impressive list of accolades ... Grace Bay was ranked as the #2 beach in the world by TripAdvisor, the ...
Breaking Medicine News(10 mins):Health News:Sofia Vergara Partners With SharkNinja® To Launch The Ninja Coffee Bar™ 2Health News:Sofia Vergara Partners With SharkNinja® To Launch The Ninja Coffee Bar™ 3Health News:TJS Insurance Group Is Latest Partner Firm To Join United Benefit Advisors 2Health News:TJS Insurance Group Is Latest Partner Firm To Join United Benefit Advisors 3Health News:PYA Offers Complimentary CCJR Webina — Game On 2Health News:PYA Offers Complimentary CCJR Webina — Game On 3Health News:Santa Rosa Consulting Recognized by Modern Healthcare as One of the Top 100 Best Places to Work and from KLAS Research with the Highest Rating for Go-Live Support 2Health News:Grace Bay Beach Acknowledged as a Top Caribbean Beach for Weddings 2
... in the recent years. But a new study has found ... took such vows. // ,The study also questions ... gauging how well they adhere to these pledges, reports foodconsumer.org. ... or written declarations to remain a virgin until marriage. ...
... in the arm for researchers of biological intelligence in the ... resemble a baby infant’s learning process, aided by it’s ... roboticists from Italy, France and Switzerland, is an ingenious effort ... similar manner of experimenting with objects available, and imbibing the ...
... the US it was found that the condition has fast ... disorder that is afflicting an estimated 300,000 U.S. schoolchildren, or ... estimate contraindicates with the estimate of 1 in every 2,000 ... about an argument as to whether the higher prevalence reflects ...
... as a beneficial and healthy activity. With the emphasis slowly, ... there’s nothing like a bit of gardening to rev up ... Institute at Northwestern Memorial Hospital in Chicago says that the ... when you bend down at your knees. "It's going to ...
... Syndrome or the shaking leg syndrome is a common type of ... their legs//. For the first time Europe has approved the drug ... and causes aches and pains. Statistics show that about 10% of ... was given by the European Medicines Agency. As of now it ...
... non-hormonal male contraceptive device that targets sperms, called Intra Vas ... study// involving 90 men. Men and women have long been ... this first male contraceptive to be marketed market may not ... place in Seattle, Washington and St. Paul, Minnesota, will bring ...
Cached Medicine News:Health News:Teenagers Often Deny Taken ‘Virginity Pledges 2Health News:Burn Away Calories In Your Garden 2Health News:Non-Hormonal Male Contraceptive Based on Sperm Block Underway 2
(Date:8/28/2015)... y LONDRES, 28 de agosto de 2015 ... anunció hoy su participación en el  Congreso de ... soluciones cardiológicas más recientes y novedosas, entre ellas ... conectan a las personas y la tecnología con ... a diagnosticar, guiar los tratamientos y permitir atención ...
(Date:8/28/2015)... August 28, 2015 The global ... USD 49.12 billion by 2020, growing at a CAGR ... new report by Grand View Research, Inc. Monitoring services ... 49.7% from 2014 to 2020.      (Logo: ... along with rising incidences of chronic diseases such as ...
(Date:8/27/2015)... , Aug. 27, 2015  A recent study ... Knee Journal, compared the Arthrosurface HemiCAP® Wave implant, ... versus an "onlay" design implant for isolated patellofemoral ... in function and pain scores, none of the ... osteoarthritis (OA). However, 53% of the patients in ...
Breaking Medicine Technology:Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 2Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 3Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 4Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 5mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 3mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 4mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 5Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 2Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 3
... HeartWare International, Inc. (Nasdaq: HTWR ; ASX: ... support technologies that are revolutionizing the treatment of advanced ... scheduled to make an investor presentation at the 29th ... Time on Monday, January 10, 2011. The conference is ...
... MOUNTAIN VIEW, Calif., Jan. 4, 2011 MAP Pharmaceuticals, Inc. ... will present at the 29th Annual J.P. Morgan Healthcare Conference ... San Francisco. A live webcast of the ... MAP Pharmaceuticals, website at http://www.mappharma.com . A replay will ...
Cached Medicine Technology:HeartWare to Present at the 29th Annual J.P. Morgan Healthcare Conference 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: