Navigation Links
Novel approach strips staph of virulence
Date:2/14/2008

, he wondered if any could turn staph colorless and make them once again susceptible to the immune system.

Colleagues in Taiwan determined the structure of the enzyme that triggers the first critical step in staphs pigment formation and observed striking similarities to an enzyme involved in human cholesterol production. They also captured the structures of several cholesterol-lowering drugs bound to the bacterial enzyme.

Building on their 2005 research that sparked the current study, Victor Nizet, M.D., and George Liu, M.D., Ph.D., now at Cedars-Sinai Medical Center in Los Angeles, Calif., tested eight different drug compounds that act on the human cholesterol enzyme. Three blocked pigment production in laboratory tests. When the researchers treated mice infected with S. aureus with one of the compounds, the bacterial population was reduced by 98 percent.

Because the approach reduces the virulence of the bacteria by stopping pigment production, it may not cause selective pressures on the population, which can lead to antibiotic resistance. It also targets only S. aureus, possibly reducing side effects.

This is an entirely new approach that seems to work in animals, and now we need to take the next step to explore if it will work in humans, said Oldfield.


'/>"/>

Contact: Emily Carlson
carlsone@nigms.nih.gov
301-496-7301
NIH/National Institute of General Medical Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UCSD research team identifies novel anticancer drug from the sea
2. Novel compound may lessen heart attack damage
3. Novel molecules developed at UB can boost vaccine potency
4. Novel small molecule therapy shows benefit for anemic patients via hydration of red blood cells
5. Novel vaccine concept developed by scientists at the Wistar Institute
6. Tibotec Pharmaceuticals a Respectful Partner to HIV Community in Pricing of Novel New HIV NNRTI, INTELENCE
7. Millennium and Harvard Medical School Sign Cooperative Agreement for Research in Novel Field of Cancer Biology
8. Statement by AARP CEO Bill Novelli on President Bushs State of the Union
9. New method enables design, production of extremely novel drugs
10. Nerites Receives NIH Grant to Study Novel Treatment for Preventing Dangerous Bacterial Infections on Urinary Stents and Catheters
11. Speedy Procedures Demonstrate Excitement and Continued Interest in Novel Multi-Electrode Ablation System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Boulder, Colorado (PRWEB) January 22, 2015 Four years ... is Queen – which coincided with the marriage of Avasa & ... album, THE ROAD, which is scheduled for release through White Swan ... heartfelt message that there is a sacred path available to all ...
(Date:1/22/2015)... Mass. (PRWEB) January 22, 2015 EBSCO ... (AMA) are expanding their relationship in an effort to ... around the world. While EBSCO has long made AMA journals ... a sales agent for The JAMA Network. , ...
(Date:1/22/2015)... a famous dress online store for wedding dresses and other ... of wedding dresses , and launches a site-wide women’s dress ... on your big day; the wedding gown is the most ... find the most suitable wedding dress. Now, we are proud ...
(Date:1/22/2015)... released a new blog post explaining the importance of keeping a ... of an auto insurance policy . , Clients who driver ... their vehicle insurance policies. The safety a vehicle offers from its ... of this, drivers should always carry a first aid kit in ...
(Date:1/22/2015)... Ga., USA (PRWEB) January 22, 2015 ... a statewide data management system with support from GEOSYSTEMS, ... , The new solution will leverage Hexagon Geospatial’s ... and vector data as well as point clouds and ...
Breaking Medicine News(10 mins):Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 3
... to aggressively challenge patents on drugs in the US despite ... generic Omeprazole 40 mg capsules by the US Food and ... and gastric ulcers. ,The FDA granted the marketing exclusivity ... exclusivity is a setback for Dr Reddy’s, but this will ...
... UK scientists say they have discovered molecules in ... action of free radicals.With further research, the research ... degenerative diseases.// Oxidative damage has been linked with ... like arthritis and diabetes, cancer and Alzheimer’s disease. ...
... A new ray of hope for hearing impairment. A new ... better sound quality than a more conventional aid. Doctors say ... loss.//The usual kind of hearing aid transmits sound through the ... - as well as giving the wearer the feeling of ...
... the third leading cause of death in the United States, ... stroke every year, and 167,000 die from it. Men who ... as likely// to die from a stroke as other men. ... to have non-fatal strokes. ,Researchers studied 2000 men aged ...
... is a very easy and simple way to slow down ... and reciting the Rosary respiration rate can be slowed down ... The Rosary// is an important prayer ritual in the Catholic ... ,Researchers at the University of Cleavland, recorded breathing rates ...
... artists are similar to those endured by professional athletes. ... conditioning, often eight to ten hours of practice daily.// ... tremendous amounts of stress in the upper extremities during ... orthopaedic surgery at Harvard Medical School in Boston, at ...
Cached Medicine News:
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... "Infectious Disease Diagnostics Market by Product, Application, Technology, ... to their offering. , The infectious disease ... 7.9% to reach $18,156.2 million by 2019 from $12,422.8 ...
(Date:1/22/2015)... ( http://www.researchandmarkets.com/research/w25xpc/allergy ) has announced the addition of ... by End User - Global Forecast to 2019" report ... market is valued at $1,228.58 million in 2014 and is ... $2,230.72 million by 2019. Allergy diagnostics is used to determine ...
(Date:1/22/2015)... ( http://www.researchandmarkets.com/research/tl6pqb/xray_detectors ) has announced the addition of ... by FPD Panel Size - Global Forecast to 2019" ... detectors market is a growing field that has witnessed a ... shift from film to filmless imaging. Hospitals and medical imaging ...
Breaking Medicine Technology:Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 2Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 3Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 2Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 3Global X-Ray Detectors (Flat Panel, Computed Radiography, CCD, Line-Scan) Market - Forecast to 2019 2Global X-Ray Detectors (Flat Panel, Computed Radiography, CCD, Line-Scan) Market - Forecast to 2019 3
... Colorcon, Inc. today announced the acquisition of the full-service ... acquisition expands Colorcon,s global excipient product offerings in the pharmaceutical ... , , ... spheres complements Colorcon,s SureSpheres® sugar spheres product line and barrier ...
... MISSISSAUGA, Ontario , April 22 CardioGenics Inc. (OTC ... segment of the IVD testing market, will be spotlighted in three publications ... Design Technology and The Wall Street Transcript . , ... In the April 2010 ...
Cached Medicine Technology:Colorcon Acquires Pharmaceutical Excipient Company - NP Pharm 2CardioGenics to be Spotlighted in Three Publications During Month of April 2CardioGenics to be Spotlighted in Three Publications During Month of April 3CardioGenics to be Spotlighted in Three Publications During Month of April 4
Facial Mask...
Abdominal Binders - 9" & 12"...
Ideal for abdominal and flank procedures....
CDIs 2nd Stage Abdominoplasty Girdle - a feminine, easy pull-on version of the 8000 series...
Medicine Products: