Navigation Links
Novel Photoconductive Cellular Depolarization Technology Reveals Insight Into Neuronal Growth, Guidance, and Regeneration
Date:1/30/2009

BOSTON, Jan. 30 /PRNewswire/ -- Neurosilicon's novel Photoconductive Stimulation Device (PSD) was highlighted in the recent scientific publication by Hung and Colicos titled, Astrocytic Ca2+ Waves Guide CNS Growth Cones to Remote Regions of Neuronal Activity. The article appearing in the November 2008 issue of The Public Library of Science One journal focuses on the role of neuronal activity in mediating axonal guidance. It is known that the path axons follow is important in defining neuronal connectivity in the brain. Following an injury, axons must find their way back to their proper targets or find new ones in order to achieve functional recovery. Given this, researchers have sought to better understand how axon guidance is mediated in order to potentially aid in recovery following injury.

Focusing on the affects of action potential induced depolarization, Hung and Colicos sought to extend previous findings and investigate how axonal growth cones respond to actual physiological stimulation in spatially displaced neurons. To do this' they applied photoconductive stimulation technology. One of the strengths of photoconductive stimulation is that it is optically activated and therefore non-invasive, requiring no physical cellular perturbation to elicit depolarization. Additionally, photoconductive stimulation has greater spatial specificity than extracellular field stimulation as well as greater temporal resolution than direct neurotransmitter application. Previously, photoconductive stimulation has been applied to demonstrate activity-driven new synapse formation in cultured neurons while allowing for the dynamic observation of the cellular elements within the neurons. In the current study, the application of photoconductive stimulation induced high frequency action potentials revealing that activity serves as an attractant signal for growth cones. These observations suggest a signaling pathway for activity-dependant axon guidance in which growth guidance both spatial and temporal is mediated by neuronal activity. Further under experimental conditions simulating injury, it was observed that growth cone attraction was not inhibited suggesting that this mechanism could be used to guide neuronal regeneration following axonal injury.

Photoconductive stimulation has enabled researchers to significantly expand the depth, breadth, and complexity of approaches aimed at understanding and addressing areas of unmet neurological healthcare need. This novel technology provides researchers with the means to dynamically study excitation dependent cellular responses without the requirement for a direct physical link to the cell (such as with electrodes in patch clamping or transistor contact necessary in micro electrode arrays). The PSD can also be used in place of pharmacological agonist stimulation, which does not allow for specific cell targeting and/or rapid repetitive depolarization.

About Neurosilicon

Neurosilicon develops novel brain-computing interfaces to expand the scientific understanding of the human brain and to revolutionize and improve the effectiveness of drug discovery. The company's flagship product, the Photoconductive Stimulation Device (PSD) stimulates excitable cells in a precise and controllable fashion. Neurosilicon is comprised of a multidisciplinary team of neuroscientists and engineers working together to advance the boundaries of life science research.

For more information on the (PSD), or to order, please visit http://www.neurosilicon.com


'/>"/>
SOURCE Neurosilicon
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
2. Novel virus detection identifies new viruses in study of respiratory infections and asthma attacks
3. Researchers uncover novel mechanism that balances the sizes of functional areas in the brain
4. Novel Cooling Therapy May Have Aided Injured Football Player
5. ECLIPSE data on effects of Otsukas investigational novel treatment, Tolvaptan
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. GrantAdler Shipping Novel Implantable Vascular Access Port
8. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
9. Novel strategy under study for aggressive leukemia
10. ISTO Technologies Receives 510(k) Clearance for a Novel Bone Graft Substitute and Bone Graft Extender
11. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... GREENVILLE, SC (PRWEB) , ... January 23, 2017 ... ... which is the premiere organization in North America for the scientific development, healthcare ... its 2017 Annual Scientific Session, and its 2017 AAT Member Certification Qualification Courses ...
(Date:1/23/2017)... ... January 23, 2017 , ... Steviva Ingredients, makers of all-natural ... USDA National Organic Program (NOP) for its Portland SQF Level 2 manufacturing facility. ... and handling systems to complement our current rigorous food-safety management systems,” said Yishu ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... general gynecological care and gynecological services for women of all ages. ... for a wide variety of reproductive services from routine health screenings to diagnosing ...
(Date:1/23/2017)... ... ... “Life Under Blankets”: an entrancing story about one woman's travels through the ... creation of published author, Kimberly Mitchell, who earned her bachelor’s degree in English education ... a master’s degree in education in the field of curriculum and instruction. Kimberly’s passion ...
(Date:1/22/2017)... Boca Raton, FL (PRWEB) , ... January 22, 2017 , ... ... products to customers across the world, recently met with big-name retail buyers at the ... strong scientific evidence of efficacy and uses the utmost safety standards in all of ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... N.Y. , Jan. 23, 2017 LifeVac, ... from a blocked airway and prevented choking deaths, welcomes ... awareness advocate to the LifeVac team as Official Spokesperson. ... Steve join the LifeVac team," said Arthur Lih ... positioned to represent LifeVac and his mission to raise ...
(Date:1/23/2017)... , Jan 23, 2017 Research and Markets has ... & Trends - Product - Forecast to 2025" report to their ... Report Highlights: ... future market trends to identify the investment opportunities Market ... Key market trends across the business segments, Regions and Countries ...
(Date:1/23/2017)... January 23, 2017 Stock-Callers.com today presents ... (NASDAQ: CPRX ), Sophiris Bio Inc. (NASDAQ: ... ), and Agile Therapeutics Inc. (NASDAQ: AGRX ). ... somewhat lower in late trade on Friday, January 20 th ... 0.3%, while shares of health care companies in the S&P ...
Breaking Medicine Technology: